The WWOX tumor suppressor is essential for postnatal survival and normal bone metabolism
about
Identification of IGF1, SLC4A4, WWOX, and SFMBT1 as hypertension susceptibility genes in Han Chinese with a genome-wide gene-based association studyTransforming growth factor beta1 signaling via interaction with cell surface Hyal-2 and recruitment of WWOX/WOX1Histone-modifying enzymes, histone modifications and histone chaperones in nucleosome assembly: Lessons learned from Rtt109 histone acetyltransferasesTumor Suppressor Genes within Common Fragile Sites Are Active Players in the DNA Damage ResponsePleiotropic Functions of Tumor Suppressor WWOX in Normal and Cancer CellsIntegrative microRNA and proteomic approaches identify novel osteoarthritis genes and their collaborative metabolic and inflammatory networksThe tumour suppressor gene WWOX is mutated in autosomal recessive cerebellar ataxia with epilepsy and mental retardationGeneration and characterization of mice carrying a conditional allele of the Wwox tumor suppressor geneComplement C1q activates tumor suppressor WWOX to induce apoptosis in prostate cancer cells.WWOX gene is associated with HDL cholesterol and triglyceride levels.Diverse effect of WWOX overexpression in HT29 and SW480 colon cancer cell lines.Genome-wide QTL mapping of nine body composition and bone mineral density traits in pigs.Epigenetic pathways regulating bone homeostasis: potential targeting for intervention of skeletal disorders.Drosophila orthologue of WWOX, the chromosomal fragile site FRA16D tumour suppressor gene, functions in aerobic metabolism and regulates reactive oxygen species.Zfra is a small wizard in the mitochondrial apoptosisCommon fragile site tumor suppressor genes and corresponding mouse models of cancer.Frequent attenuation of the WWOX tumor suppressor in osteosarcoma is associated with increased tumorigenicity and aberrant RUNX2 expression.WWOX expression in colorectal cancer--a real-time quantitative RT-PCR study.Investigation of osteosarcoma genomics and its impact on targeted therapy: an international collaboration to conquer human osteosarcoma.Loss of wwox expression in zebrafish embryos causes edema and alters Ca(2+) dynamicsThe WWOX gene modulates high-density lipoprotein and lipid metabolism.The cancer gene WWOX behaves as an inhibitor of SMAD3 transcriptional activity via direct bindingCorrelation of WWOX, RUNX2 and VEGFA protein expression in human osteosarcomaCharacterizing WW domain interactions of tumor suppressor WWOX reveals its association with multiprotein networks.Identification of an In Vivo MEK/WOX1 Complex as a Master Switch for Apoptosis in T Cell Leukemia.Biophysical basis of the binding of WWOX tumor suppressor to WBP1 and WBP2 adaptorsRole of WWOX and NF-κB in lung cancer progressionAlteration of WWOX in human cancer: a clinical view.Role of WW domain proteins WWOX in development, prognosis, and treatment response of glioma.Regulation of cell signaling and apoptosis by tumor suppressor WWOX.Roles of the WWOX in pathogenesis and endocrine therapy of breast cancer.Strategies of oncogenic microbes to deal with WW domain-containing oxidoreductaseTargeted ablation of the WW domain-containing oxidoreductase tumor suppressor leads to impaired steroidogenesis.Molecular origin of the binding of WWOX tumor suppressor to ErbB4 receptor tyrosine kinase.The supposed tumor suppressor gene WWOX is mutated in an early lethal microcephaly syndrome with epilepsy, growth retardation and retinal degeneration.Conditional inactivation of the mouse Wwox tumor suppressor gene recapitulates the null phenotype.WWOX gene and gene product: tumor suppression through specific protein interactions.Signaling from membrane receptors to tumor suppressor WW domain-containing oxidoreductase.Role of the WWOX tumor suppressor gene in bone homeostasis and the pathogenesis of osteosarcoma.WW domain-containing oxidoreductase's role in myriad cancers: clinical significance and future implications.
P2860
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P2860
The WWOX tumor suppressor is essential for postnatal survival and normal bone metabolism
description
2008 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2008
@ast
im August 2008 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2008/08/01)
@sk
vědecký článek publikovaný v roce 2008
@cs
wetenschappelijk artikel (gepubliceerd op 2008/08/01)
@nl
наукова стаття, опублікована в серпні 2008
@uk
name
The WWOX tumor suppressor is essential for postnatal survival and normal bone metabolism
@ast
The WWOX tumor suppressor is essential for postnatal survival and normal bone metabolism
@en
The WWOX tumor suppressor is essential for postnatal survival and normal bone metabolism
@nl
type
label
The WWOX tumor suppressor is essential for postnatal survival and normal bone metabolism
@ast
The WWOX tumor suppressor is essential for postnatal survival and normal bone metabolism
@en
The WWOX tumor suppressor is essential for postnatal survival and normal bone metabolism
@nl
prefLabel
The WWOX tumor suppressor is essential for postnatal survival and normal bone metabolism
@ast
The WWOX tumor suppressor is essential for postnatal survival and normal bone metabolism
@en
The WWOX tumor suppressor is essential for postnatal survival and normal bone metabolism
@nl
P2093
P2860
P50
P356
P1476
The WWOX tumor suppressor is essential for postnatal survival and normal bone metabolism
@en
P2093
Gary S. Stein
Jane B. Lian
John P. Hagan
Mohammad Q. Hassan
Rami I. Aqeilan
Sadiq Hussain
Suk-Hee Lee
Titziana Palumbo
Tripti Gaur
P2860
P304
21629–21639
P356
10.1074/JBC.M800855200
P407
P577
2008-08-01T00:00:00Z