The glycine binding site of the N-methyl-D-aspartate receptor subunit NR1: identification of novel determinants of co-agonist potentiation in the extracellular M3-M4 loop region.
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Glutamate receptors in neuroinflammatory demyelinating diseaseBiochemical evidence for the co-association of three N-methyl-D-aspartate (NMDA) R2 subunits in recombinant NMDA receptorsLarge conductance voltage- and calcium-dependent K+ channel, a distinct member of voltage-dependent ion channels with seven N-terminal transmembrane segments (S0-S6), an extracellular N terminus, and an intracellular (S9-S10) C terminusMechanisms of activation, inhibition and specificity: crystal structures of the NMDA receptor NR1 ligand-binding coreCharacterization of the binding of two novel glycine site antagonists to cloned NMDA receptors: evidence for two pharmacological classes of antagonistsAllosteric modulation of [3H]-CGP39653 binding through the glycine site of the NMDA receptor: further studies in rat and human brainDesensitization of NMDA receptor channels is modulated by glutamate agonists.The NR1 subunit of the N-methyl-D-aspartate receptor can be efficiently expressed alone in the cell surface of mammalian cells and is required for the transport of the NR2A subunitExcitatory glycine receptors containing the NR3 family of NMDA receptor subunitsInfluence of a threonine residue in the S2 ligand binding domain in determining agonist potency and deactivation rate of recombinant NR1a/NR2D NMDA receptorsThe involvement of N-methyl-D-aspartate receptor (NMDAR) subunit NR1 in the pathophysiology of schizophrenia.Modulation of the dimer interface at ionotropic glutamate-like receptor delta2 by D-serine and extracellular calcium.Src, a molecular switch governing gain control of synaptic transmission mediated by N-methyl-D-aspartate receptors.Recent excitement in the ionotropic glutamate receptor field.Structural determinants of D-cycloserine efficacy at the NR1/NR2C NMDA receptorsInfluence of the NR3A subunit on NMDA receptor functions.Glycine-site antagonists and stroke.Rescue of abnormal phenotypes of the delta2 glutamate receptor-null mice by mutant delta2 transgenes.Staggering of subunits in NMDAR channels.NMDA receptor and neonatal hypoxic brain injury.Retention of NMDA receptor NR2 subunits in the lumen of endoplasmic reticulum in targeted NR1 knockout mice.Affinity labeling of cysteine-mutants evidences contact residues in modeled receptor binding sites.Does anesthetic additivity imply a similar molecular mechanism of anesthetic action at N-methyl-D-aspartate receptors?Glycine-dependent activation of NMDA receptors.The N-methyl D-aspartate receptor glycine site and D-serine metabolism: an evolutionary perspectiveProlongation of levodopa responses by glycineB antagonists in parkinsonian primatesModulation of NMDA receptor properties and synaptic transmission by the NR3A subunit in mouse hippocampal and cerebrocortical neuronsStoichiometry of recombinant N-methyl-D-aspartate receptor channels inferred from single-channel current patterns.Gating reaction mechanism of neuronal NMDA receptors.Ginsenosides: are any of them candidates for drugs acting on the central nervous system?Alterations in NMDA receptor subunit densities and ligand binding to glycine recognition sites are associated with chronic anxiety in Alzheimer's diseaseIonotropic glutamate receptors: Which ones, when, and where in the mammalian neocortex.The Glutamate-Glutamine Cycle in Epilepsy.Afferent Input Selects NMDA Receptor Subtype to Determine the Persistency of Hippocampal LTP in Freely Behaving MiceThe selectivity of conantokin-G for ion channel inhibition of NR2B subunit-containing NMDA receptors is regulated by amino acid residues in the S2 region of NR2B.The integrity of the glycine co-agonist binding site of N-methyl-D-aspartate receptors is a functional quality control checkpoint for cell surface delivery.Disruption of AMPA receptor GluR2 clusters following long-term depression induction in cerebellar Purkinje neurons.N-Methyl-D-aspartate (NMDA) receptor subunit NR1 forms the substrate for oligomeric assembly of the NMDA receptor.Effects of amino acid substitutions in transmembrane domains of the NR1 subunit on the ethanol inhibition of recombinant N-methyl-D-aspartate receptors.Subunit assembly of N-methyl-d-aspartate receptors analyzed by fluorescence resonance energy transfer.
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The glycine binding site of the N-methyl-D-aspartate receptor subunit NR1: identification of novel determinants of co-agonist potentiation in the extracellular M3-M4 loop region.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on June 1996
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
The glycine binding site of th ...... tracellular M3-M4 loop region.
@en
The glycine binding site of th ...... tracellular M3-M4 loop region.
@nl
type
label
The glycine binding site of th ...... tracellular M3-M4 loop region.
@en
The glycine binding site of th ...... tracellular M3-M4 loop region.
@nl
prefLabel
The glycine binding site of th ...... tracellular M3-M4 loop region.
@en
The glycine binding site of th ...... tracellular M3-M4 loop region.
@nl
P2093
P2860
P356
P1476
The glycine binding site of th ...... xtracellular M3-M4 loop region
@en
P2093
P2860
P304
P356
10.1073/PNAS.93.12.6031
P407
P577
1996-06-01T00:00:00Z