7-Chlorokynurenic acid is a selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex - Wikidata - wikimedia - TriplyDB

7-Chlorokynurenic acid is a selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex

7-Chlorokynurenic acid is a selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex

http://www.wikidata.org/entity/Q24649753

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Enantiomers of HA-966 (3-amino-1-hydroxypyrrolid-2-one) exhibit distinct central nervous system effects: (+)-HA-966 is a selective glycine/N-methyl-D-aspartate receptor antagonist, but (-)-HA-966 is a potent gamma-butyrolactone-like sedative Changing the face of kynurenines and neurotoxicity: therapeutic considerations Glutamate receptor ion channels: structure, regulation, and function The Prodrug 4-Chlorokynurenine Causes Ketamine-Like Antidepressant Effects, but Not Side Effects, by NMDA/GlycineB-Site Inhibition.Modulation of seizure susceptibility in the mouse by the strychnine-insensitive glycine recognition site of the NMDA receptor/ion channel complex.Modulation of N-methyl-D-aspartate receptor function by glycine transport.Glycine-site antagonists and stroke.Kinetic analysis of antagonist action at N-methyl-D-aspartic acid receptors. Two binding sites each for glutamate and glycine.The NMDA receptor as a target for cognitive enhancement Glycine-like modulation of N-methyl-D-aspartate receptors by a monoclonal antibody that enhances long-term potentiation.E-p-methoxycinnamic acid protects cultured neuronal cells against neurotoxicity induced by glutamate.Modulation of glycine receptors in retinal ganglion cells by zinc.The specific role of cGMP in hippocampal LTP.D-serine and serine racemase are present in the vertebrate retina and contribute to the physiological activation of NMDA receptors Neurotoxin-related research: from the laboratory to the clinic.Excitatory amino acid antagonists and their potential for the treatment of ischaemic brain damage in man.New advances in NMDA receptor pharmacology.Ischemic preconditioning protects neurons from damage and maintains the immunoreactivity of kynurenic acid in the gerbil hippocampal CA1 region following transient cerebral ischemia.Block of NMDA receptor channels by endogenous neurosteroids: implications for the agonist induced conformational states of the channel vestibule.Cycloleucine blocks NMDA responses in cultured hippocampal neurones under voltage clamp: antagonism at the strychnine-insensitive glycine receptor Stimulation of noradrenaline release in human cerebral cortex mediated by N-methyl-D-aspartate (NMDA) and non-NMDA receptors.Actions of agonists of metabotropic glutamate receptors on synaptic transmission and transmitter release in the olfactory cortex.NMDA antagonists increase recovery of evoked potentials from slices of rat olfactory cortex after anoxia.Transsynaptic neuronal loss induced in hippocampal slice cultures by a herpes simplex virus vector expressing the GluR6 subunit of the kainate receptor.Metabotropic NMDA receptor function is required for NMDA receptor-dependent long-term depression.Identity of endogenous NMDAR glycine site agonist in amygdala is determined by synaptic activity level Familial and developmental abnormalities of front lobe function and neurochemistry in schizophrenia.Kynurenic Acid in the digestive system-new facts, new challenges.Glycine site of NMDA receptor serves as a spatiotemporal detector of synaptic activity patterns Inhibition of glycine transporter-1 in the dorsal vagal complex improves metabolic homeostasis in diabetes and obesity.The glycine binding site of the N-methyl-D-aspartate receptor subunit NR1: identification of novel determinants of co-agonist potentiation in the extracellular M3-M4 loop region.The allosteric glycine site of the N-methyl-D-aspartate receptor modulates GABAergic-mediated synaptic events in neonatal rat CA3 hippocampal neurons.Glycine decreases desensitization of N-methyl-D-aspartate (NMDA) receptors expressed in Xenopus oocytes and is required for NMDA responses.Pharmacological modulation of NMDA receptor activity and the advent of negative and positive allosteric modulators Some molecular mechanisms of dopaminergic and glutamatergic dysfunctioning in Parkinson's disease.Serine racemase as a prime target for age-related memory deficits.Preferential Disruption of Prefrontal GABAergic Function by Nanomolar Concentrations of the α7nACh Negative Modulator Kynurenic Acid.Targeting glutamate signalling in depression: progress and prospects.Searching for presynaptic NMDA receptors in the nucleus accumbens.Oral pharmacotherapy for the movement disorders of cerebral palsy.

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7-Chlorokynurenic acid is a selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex

http://www.wikidata.org/entity/Q24649753

description

1988 nî lūn-bûn

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1988 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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1988 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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1988年の論文

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1988年論文

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1988年論文

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1988年論文

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1988年論文

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1988年論文

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1988年论文

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Proceedings of the National Academy of Sciences of the United States of America

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7-Chlorokynurenic acid is a se ...... l-D-aspartate receptor complex

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A C Foster

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G N Woodruff

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J A Kemp

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L L Iversen

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P D Leeson

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T Priestley

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P2860

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist

The affinities, potencies and efficacies of some benzodiazepine-receptor agonists, antagonists and inverse-agonists at rat hippocampal GABAA-receptors

3H-labeled MK-801 binding to the excitatory amino acid receptor complex from rat brain is enhanced by glycine

A comparison of excitatory amino acid antagonists acting at primary afferent C fibres and motoneurones of the isolated spinal cord of the rat.

Comparison of L-[3H]glutamate, D-[3H]aspartate, DL-[3H]AP5 and [3H]NMDA as ligands for NMDA receptors in crude postsynaptic densities from rat brain.

Biochemical evidence that glycine allosterically regulates an NMDA receptor-coupled ion channel.

Glycine modulates [3H]MK-801 binding to the NMDA receptor in rat brain.

Enhanced survival of rat neonatal cerebral cortical neurons at subatmospheric oxygen tensions in vitro.

CPP, a new potent and selective NMDA antagonist. Depression of central neuron responses, affinity for [3H]D-AP5 binding sites on brain membranes and anticonvulsant activity.

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2842779

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