Developing intrabodies for the therapeutic suppression of neurodegenerative pathology.
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Intrabodies as neuroprotective therapeuticsIBC's 23rd Annual Antibody Engineering, 10th Annual Antibody Therapeutics international conferences and the 2012 Annual Meeting of The Antibody Society: December 3-6, 2012, San Diego, CAPhysico-chemical determinants of soluble intrabody expression in mammalian cell cytoplasm.Cystamine and intrabody co-treatment confers additional benefits in a fly model of Huntington's disease.Bifunctional anti-huntingtin proteasome-directed intrabodies mediate efficient degradation of mutant huntingtin exon 1 protein fragments.Molecular mechanisms and potential therapeutical targets in Huntington's disease.Research and development of next generation of antibody-based therapeuticsImmunopharmacology: utilizing antibodies as ion channel modulators.Engineered antibody therapies to counteract mutant huntingtin and related toxic intracellular proteinsPharmacokinetics, pharmacodynamics and physiologically-based pharmacokinetic modelling of monoclonal antibodies.Gene-based antibody strategies for prion diseases.Recombinant Antibody Fragments for Neurodegenerative Diseases.Fusion to a highly charged proteasomal retargeting sequence increases soluble cytoplasmic expression and efficacy of diverse anti-synuclein intrabodies.Nucleic Acid-Based Therapy Approaches for Huntington's DiseaseA bispecific transmembrane antibody simultaneously targeting intra- and extracellular epitopes of the epidermal growth factor receptor inhibits receptor activation and tumor cell growth.
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Developing intrabodies for the therapeutic suppression of neurodegenerative pathology.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on September 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Developing intrabodies for the therapeutic suppression of neurodegenerative pathology.
@en
Developing intrabodies for the therapeutic suppression of neurodegenerative pathology.
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type
label
Developing intrabodies for the therapeutic suppression of neurodegenerative pathology.
@en
Developing intrabodies for the therapeutic suppression of neurodegenerative pathology.
@nl
prefLabel
Developing intrabodies for the therapeutic suppression of neurodegenerative pathology.
@en
Developing intrabodies for the therapeutic suppression of neurodegenerative pathology.
@nl
P2093
P2860
P1476
Developing intrabodies for the therapeutic suppression of neurodegenerative pathology.
@en
P2093
Anne Messer
David C Butler
Sandra M Lynch
P2860
P304
P356
10.1517/14712590903176387
P407
P577
2009-09-01T00:00:00Z