Overview of molecular testing in non-small-cell lung cancer: mutational analysis, gene copy number, protein expression and other biomarkers of EGFR for the prediction of response to tyrosine kinase inhibitors.

Overview of molecular testing in non-small-cell lung cancer: mutational analysis, gene copy number, protein expression and other biomarkers of EGFR for the prediction of response to tyrosine kinase inhibitors.

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Hypoxia-induced SM22α in A549 cells activates the IGF1R/PI3K/Akt pathway, conferring cellular resistance against chemo- and radiation therapy Nuclear receptor coregulators: modulators of pathology and therapeutic targets Molecular pathology of non-small cell lung cancer: a practical guide.Does your gene need a background check? How genetic background impacts the analysis of mutations, genes, and evolution Neonatal lethality in knockout mice expressing the kinase-dead form of the gefitinib target GAK is caused by pulmonary dysfunction EGFR tyrosine kinase inhibitors activate autophagy as a cytoprotective response in human lung cancer cells In situ mutation detection and visualization of intratumor heterogeneity for cancer research and diagnostics Acquisition and processing of endobronchial ultrasound-guided transbronchial needle aspiration specimens in the era of targeted lung cancer chemotherapy.The use of COLD-PCR and high-resolution melting analysis improves the limit of detection of KRAS and BRAF mutations in colorectal cancer.Whole genome sequencing for lung cancer.Pulmonary adenocarcinoma: implications of the recent advances in molecular biology, treatment and the IASLC/ATS/ERS classification.Tailoring tyrosine kinase inhibitors to fit the lung cancer genome.Isoliquiritigenin induces apoptosis and inhibits xenograft tumor growth of human lung cancer cells by targeting both wild type and L858R/T790M mutant EGFR.Next-generation sequencing of lung cancer EGFR exons 18-21 allows effective molecular diagnosis of small routine samples (cytology and biopsy).Loss of canonical Smad4 signaling promotes KRAS driven malignant transformation of human pancreatic duct epithelial cells and metastasis.From the bench to bedside: biological and methodology considerations for the future of companion diagnostics in nonsmall cell lung cancer.Standardization of epidermal growth factor receptor (EGFR) measurement by quantitative immunofluorescence and impact on antibody-based mutation detection in non-small cell lung cancer Squamous Cell Carcinoma - Similarities and Differences among Anatomical Sites.The role of epidermal growth factor receptor tyrosine kinase inhibitors in the treatment of advanced stage non-small cell lung cancer Pancreatic endocrine tumours: mutational and immunohistochemical survey of protein kinases reveals alterations in targetable kinases in cancer cell lines and rare primaries Identification of Genetic Mutations in Human Lung Cancer by Targeted Sequencing.Epidermal Growth Factor Receptor Mutation (EGFR) Testing for Prediction of Response to EGFR-Targeting Tyrosine Kinase Inhibitor (TKI) Drugs in Patients with Advanced Non-Small-Cell Lung Cancer: An Evidence-Based Analysis Epidermal growth factor receptor inhibition in lung cancer: the evolving role of individualized therapy Two novel BRM insertion promoter sequence variants are associated with loss of BRM expression and lung cancer risk.The role of molecular analyses in the era of personalized therapy for advanced NSCLC.Tumor-targeted SN38 inhibits growth of early stage non-small cell lung cancer (NSCLC) in a KRas/p53 transgenic mouse model.Cancer genes in lung cancer: racial disparities: are there any?244-MPT overcomes gefitinib resistance in non-small cell lung cancer cells Detection of epidermal growth factor receptor mutations in formalin fixed paraffin embedded biopsies in Malaysian non-small cell lung cancer patients.Detection of EGFR mutations in circulating free DNA by PNA-mediated PCR clamping.S100A4 accelerates the proliferation and invasion of endometrioid carcinoma and is associated with the "MELF" pattern.Trivanillic polyphenols with anticancer cytostatic effects through the targeting of multiple kinases and intracellular Ca2+ release.Molecular biology of lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines.EGF receptor in lung cancer: a successful story of targeted therapy.Primary and secondary therapeutic strategies for EGF receptor pathway inhibition in non-small-cell lung cancer.Systematic review of pharmacoeconomic studies of pharmacogenomic tests.Targeting the growth factors and angiogenesis pathways: small molecules in solid tumors.Epidermal growth factor receptor as a therapeutic target in veterinary oncology.Ancillary testing in lung cancer diagnosis.Cancer treatment according to BRCA1 and BRCA2 mutations.

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P2860

Overview of molecular testing in non-small-cell lung cancer: mutational analysis, gene copy number, protein expression and other biomarkers of EGFR for the prediction of response to tyrosine kinase inhibitors.

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http://www.wikidata.org/entity/Q37579644

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article científic

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artigo científico

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bilimsel makale

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scientific article published on August 2009

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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