A single amino acid substitution strongly modulates the activity and substrate specificity of the mouse mdr1 and mdr3 drug efflux pumps.
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Biochemical properties of a minimal functional domain with ATP-binding activity of the NTPase/helicase of hepatitis C virusNanoparticle mediated P-glycoprotein silencing for improved drug delivery across the blood-brain barrier: a siRNA-chitosan approachAn increase in reactive oxygen species by deregulation of ARNT enhances chemotherapeutic drug-induced cancer cell deathSmall molecules that dramatically alter multidrug resistance phenotype by modulating the substrate specificity of P-glycoproteinGenetic separation of FK506 susceptibility and drug transport in the yeast Pdr5 ATP-binding cassette multidrug resistance transporter.The DrrAB efflux system of Streptomyces peucetius is a multidrug transporter of broad substrate specificityAnthelmintics are substrates and activators of nematode P glycoprotein.Functional complementation of the ste6 gene of Saccharomyces cerevisiae with the pfmdr1 gene of Plasmodium falciparum.Chemical specificity of the PDR5 multidrug resistance gene product of Saccharomyces cerevisiae based on studies with tri-n-alkyltin chlorides.Overexpression of the cystic fibrosis transmembrane conductance regulator in NIH 3T3 cells lowers membrane potential and intracellular pH and confers a multidrug resistance phenotype.Multidrug-resistant human sarcoma cells with a mutant P-glycoprotein, altered phenotype, and resistance to cyclosporins.Gene rearrangement: a novel mechanism for MDR-1 gene activationFunctional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivoCell biological mechanisms of multidrug resistance in tumors.Regulation of initial vinblastine influx by P-glycoproteinInteraction of multidrug-resistant Chinese hamster ovary cells with amphiphilesP-glycoprotein structure and evolutionary homologies.Flavonoids: a class of modulators with bifunctional interactions at vicinal ATP- and steroid-binding sites on mouse P-glycoproteinSingle nucleotide polymorphisms in human P-glycoprotein: its impact on drug delivery and disposition.Are altered pHi and membrane potential in hu MDR 1 transfectants sufficient to cause MDR protein-mediated multidrug resistance?Functional expression of mouse mdr1 in Escherichia coli.Evidence for two nonidentical drug-interaction sites in the human P-glycoproteinFunctional expression of P-glycoprotein in Saccharomyces cerevisiae confers cellular resistance to the immunosuppressive and antifungal agent FK520.Functional expression of P-glycoprotein encoded by the mouse mdr3 gene in yeast cellsAmino acid substitutions in the sixth transmembrane domain of P-glycoprotein alter multidrug resistance.Molecular analysis of the multidrug transporter, P-glycoprotein.The pfmdr1 gene of Plasmodium falciparum confers cellular resistance to antimalarial drugs in yeast cells.P-glycoprotein confers methotrexate resistance in 3T6 cells with deficient carrier-mediated methotrexate uptake.Genetic analysis of bacterial acetyltransferases: identification of amino acids determining the specificities of the aminoglycoside 6'-N-acetyltransferase Ib and IIa proteins.Transmembrane organization of mouse P-glycoprotein determined by epitope insertion and immunofluorescence.The therapeutic potential of targeting ABC transporters to combat multi-drug resistance.Susceptibility of an emetine-resistant mutant of Entamoeba histolytica to multiple drugs and to channel blockers.P-glycoprotein-mediated transport of itraconazole across the blood-brain barrier.Mutations affecting substrate specificity of the Bacillus subtilis multidrug transporter Bmr.The genetic basis of resistance to cancer chemotherapy.The topography of transmembrane segment six is altered during the catalytic cycle of P-glycoprotein.Location of the rhodamine-binding site in the human multidrug resistance P-glycoprotein.Contribution of P-glycoprotein to efflux of ramosetron, a 5-HT3 receptor antagonist, across the blood-brain barrier.Cross-linking of human multidrug resistance P-glycoprotein by the substrate, tris-(2-maleimidoethyl)amine, is altered by ATP hydrolysis. Evidence for rotation of a transmembrane helix.Identification of an amino acid residue in multidrug resistance protein 1 critical for conferring resistance to anthracyclines.
P2860
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P2860
A single amino acid substitution strongly modulates the activity and substrate specificity of the mouse mdr1 and mdr3 drug efflux pumps.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on August 1991
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
A single amino acid substituti ...... r1 and mdr3 drug efflux pumps.
@en
A single amino acid substituti ...... r1 and mdr3 drug efflux pumps.
@nl
type
label
A single amino acid substituti ...... r1 and mdr3 drug efflux pumps.
@en
A single amino acid substituti ...... r1 and mdr3 drug efflux pumps.
@nl
prefLabel
A single amino acid substituti ...... r1 and mdr3 drug efflux pumps.
@en
A single amino acid substituti ...... r1 and mdr3 drug efflux pumps.
@nl
P2093
P2860
P356
P1476
A single amino acid substituti ...... r1 and mdr3 drug efflux pumps.
@en
P2093
P2860
P304
P356
10.1073/PNAS.88.16.7289
P407
P577
1991-08-01T00:00:00Z