The dynorphin/kappa opioid system as a modulator of stress-induced and pro-addictive behaviors
about
Transcriptional mechanisms of drug addictionDuration of action of a broad range of selective κ-opioid receptor antagonists is positively correlated with c-Jun N-terminal kinase-1 activationSex Differences in Kappa Opioid Receptor Function and Their Potential Impact on AddictionSalvinorin A, a kappa-opioid receptor agonist hallucinogen: pharmacology and potential template for novel pharmacotherapeutic agents in neuropsychiatric disordersRole of the Brain's Reward Circuitry in Depression: Transcriptional Mechanisms15 years of genetic approaches in vivo for addiction research: Opioid receptor and peptide gene knockout in mouse models of drug abuseDynorphin--still an extraordinarily potent opioid peptideκ-opioid receptor/dynorphin system: genetic and pharmacotherapeutic implications for addictionNeuropeptide modulation of central amygdala neuroplasticity is a key mediator of alcohol dependence.Drug withdrawal conceptualized as a stressor.Stress and VTA synapses: implications for addiction and depressionThe multiple facets of opioid receptor function: implications for addictionDistinct Subpopulations of Nucleus Accumbens Dynorphin Neurons Drive Aversion and RewardDynorphin Controls the Gain of an Amygdalar Anxiety CircuitKappa Opioids, Salvinorin A and Major Depressive DisorderKappa Opioid Receptor-Induced Aversion Requires p38 MAPK Activation in VTA Dopamine NeuronsCollybolide is a novel biased agonist of κ-opioid receptors with potent antipruritic activityCharacterization of BU09059: a novel potent selective κ-receptor antagonistMitragynine attenuates withdrawal syndrome in morphine-withdrawn zebrafishCRF1-R activation of the dynorphin/kappa opioid system in the mouse basolateral amygdala mediates anxiety-like behaviorStress-Induced Reinstatement of Drug Seeking: 20 Years of Progress.Ablation of kappa-opioid receptors from brain dopamine neurons has anxiolytic-like effects and enhances cocaine-induced plasticityNeuropharmacology of the naturally occurring kappa-opioid hallucinogen salvinorin AThe effects of kappa-opioid receptor ligands on prepulse inhibition and CRF-induced prepulse inhibition deficits in the rat.Impaired periamygdaloid-cortex prodynorphin is characteristic of opiate addiction and depression.Pain-related depression of the mesolimbic dopamine system in rats: expression, blockade by analgesics, and role of endogenous κ-opioids.Constitutive activation of kappa opioid receptors at ventral tegmental area inhibitory synapses following acute stress.Virus-mediated shRNA knockdown of prodynorphin in the rat nucleus accumbens attenuates depression-like behavior and cocaine locomotor sensitization.Effects of naltrexone are influenced by childhood adversity during negative emotional processing in addiction recoveryNew evidence of ethanol's anxiolytic properties in the infant rat.Synergistic antidepressant-like effects between a kappa opioid antagonist (LY2444296) and a delta opioid agonist (ADL5859) in the mouse forced swim test.Role of the kappa-opioid receptor system in stress-induced reinstatement of nicotine seeking in rats.Structure-Based Discovery of New Antagonist and Biased Agonist Chemotypes for the Kappa Opioid ReceptorEffectiveness of analogs of the kappa opioid receptor antagonist (3R)-7-hydroxy-N-((1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (JDTic) to reduce U50,488-inducedThe role of the dynorphin-kappa opioid system in the reinforcing effects of drugs of abuseDesign, synthesis, and validation of a β-turn mimetic library targeting protein-protein and peptide-receptor interactionsTime to connect: bringing social context into addiction neuroscienceBehavioral stress may increase the rewarding valence of cocaine-associated cues through a dynorphin/kappa-opioid receptor-mediated mechanism without affecting associative learning or memory retrieval mechanismsPutative kappa opioid heteromers as targets for developing analgesics free of adverse effects.The role of kappa-opioid receptor activation in mediating antinociception and addiction.
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The dynorphin/kappa opioid system as a modulator of stress-induced and pro-addictive behaviors
description
article científic
@ca
article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 28 August 2009
@en
vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
@cs
name
The dynorphin/kappa opioid sys ...... ed and pro-addictive behaviors
@en
The dynorphin/kappa opioid sys ...... d and pro-addictive behaviors.
@nl
type
label
The dynorphin/kappa opioid sys ...... ed and pro-addictive behaviors
@en
The dynorphin/kappa opioid sys ...... d and pro-addictive behaviors.
@nl
prefLabel
The dynorphin/kappa opioid sys ...... ed and pro-addictive behaviors
@en
The dynorphin/kappa opioid sys ...... d and pro-addictive behaviors.
@nl
P2093
P2860
P1433
P1476
The dynorphin/kappa opioid sys ...... ed and pro-addictive behaviors
@en
P2093
P2860
P356
10.1016/J.BRAINRES.2009.08.062
P407
P577
2009-08-28T00:00:00Z