The fragile X protein controls microtubule-associated protein 1B translation and microtubule stability in brain neuron development.
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Gigaxonin-controlled degradation of MAP1B light chain is critical to neuronal survivalFragile X syndrome: loss of local mRNA regulation alters synaptic development and function5'-UTR RNA G-quadruplexes: translation regulation and targetingEmerging pharmacotherapies for neurodevelopmental disordersSignaling mechanisms regulating adult neural stem cells and neurogenesisA direct role for FMRP in activity-dependent dendritic mRNA transport links filopodial-spine morphogenesis to fragile X syndrome.Temporal requirements of the fragile X mental retardation protein in the regulation of synaptic structureThe Presynaptic Microtubule Cytoskeleton in Physiological and Pathological Conditions: Lessons from Drosophila Fragile X Syndrome and Hereditary Spastic ParaplegiasIn Sickness and in Health: Perineuronal Nets and Synaptic Plasticity in Psychiatric DisordersMatrix metalloproteinases and minocycline: therapeutic avenues for fragile X syndrome.The pathophysiology of fragile X (and what it teaches us about synapses)Tracking the Fragile X Mental Retardation Protein in a Highly Ordered Neuronal RiboNucleoParticles Population: A Link between Stalled Polyribosomes and RNA GranulesCellular and molecular characterization of multipolar Map5-expressing cells: a subset of newly generated, stage-specific parenchymal cells in the mammalian central nervous systemAltered Translational Control of FMRP on Myelin Proteins in Neuropsychiatric DisordersA new function for the fragile X mental retardation protein in regulation of PSD-95 mRNA stabilityA novel function for fragile X mental retardation protein in translational activationThe G-quartet containing FMRP binding site in FMR1 mRNA is a potent exonic splicing enhancerGenetic manipulation of STEP reverses behavioral abnormalities in a fragile X syndrome mouse model.Localization of FMRP-associated mRNA granules and requirement of microtubules for activity-dependent trafficking in hippocampal neuronsThe RNA binding and transport proteins staufen and fragile X mental retardation protein are expressed by rat primary afferent neurons and localize to peripheral and central axonsQKI binds MAP1B mRNA and enhances MAP1B expression during oligodendrocyte developmentSerum- and glucocorticoid-inducible kinase 1 (SGK1) increases neurite formation through microtubule depolymerization by SGK1 and by SGK1 phosphorylation of tauPhosphatidylinositol-3 kinase-dependent translational regulation of Id1 involves the PPM1G phosphataseEnhanced expression of ADCY1 underlies aberrant neuronal signalling and behaviour in a syndromic autism model.Progress toward therapeutic potential for AFQ056 in Fragile X syndrome.Behavioral analysis of male and female Fmr1 knockout mice on C57BL/6 background.From FMRP function to potential therapies for fragile X syndrome.Modeling fragile X syndrome in the Fmr1 knockout mouseFragile X syndrome: mechanistic insights and therapeutic avenues regarding the role of potassium channels.Fragile X mental retardation protein is required for rapid experience-dependent regulation of the potassium channel Kv3.1bReversal of fragile X phenotypes by manipulation of AβPP/Aβ levels in Fmr1KO micePotential therapeutic interventions for fragile X syndromeFragile X mental retardation protein has a unique, evolutionarily conserved neuronal function not shared with FXR1P or FXR2PRescue of behavioral phenotype and neuronal protrusion morphology in Fmr1 KO mice.Conserved 3'-untranslated region sequences direct subcellular localization of chaperone protein mRNAs in neurons.Fragile X mental retardation protein is required for programmed cell death and clearance of developmentally-transient peptidergic neurons.Natural selection on human microRNA binding sites inferred from SNP data.FMRP mediates mGluR5-dependent translation of amyloid precursor protein.Fragile x mental retardation protein regulates proliferation and differentiation of adult neural stem/progenitor cells.Fragile X mental retardation protein regulates translation by binding directly to the ribosome
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The fragile X protein controls microtubule-associated protein 1B translation and microtubule stability in brain neuron development.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 08 October 2004
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
The fragile X protein controls ...... y in brain neuron development.
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The fragile X protein controls ...... y in brain neuron development.
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type
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The fragile X protein controls ...... y in brain neuron development.
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The fragile X protein controls ...... y in brain neuron development.
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prefLabel
The fragile X protein controls ...... y in brain neuron development.
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The fragile X protein controls ...... y in brain neuron development.
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P2093
P2860
P356
P1476
The fragile X protein controls ...... ty in brain neuron development
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P2093
Houping Wang
Stephen T Warren
William T O'donnell
P2860
P304
15201-15206
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10.1073/PNAS.0404995101
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P50
P577
2004-10-08T00:00:00Z