'7TM receptor allostery: putting numbers to shapeshifting proteins.
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Allostery at G protein-coupled receptor homo- and heteromers: uncharted pharmacological landscapesPrinciples of allosteric interactions in cell signalingDrugs for allosteric sites on receptorsA unified view of "how allostery works"A simple method for quantifying functional selectivity and agonist biasFluorescence polarization screening for allosteric small molecule ligands of the cholecystokinin receptor.Pharmacological characterization of GPR55, a putative cannabinoid receptorSeven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery.Psychopharmacology of the endocannabinoids: far beyond anandamide.2013 Philip S. Portoghese Medicinal Chemistry Lectureship: drug discovery targeting allosteric sites.Functional selectivity in adrenergic and angiotensin signaling systems.Allosteric transition: a comparison of two modelsEnergy landscapes as a tool to integrate GPCR structure, dynamics, and function.Cross-talk between carboxypeptidase M and the kinin B1 receptor mediates a new mode of G protein-coupled receptor signalingExtracellular loop 2 of the free fatty acid receptor 2 mediates allosterism of a phenylacetamide ago-allosteric modulator.Reflections on the theory of "silver bullet" octreotide tracers: implications for ligand-receptor interactions in the age of peptides, heterodimers, receptor mosaics, truncated receptors, and multifractal analysis.Allosteric interactions between δ and κ opioid receptors in peripheral sensory neuronsAgonism/antagonism switching in allosteric ensembles.Allosteric modulation of seven transmembrane spanning receptors: theory, practice, and opportunities for central nervous system drug discoveryFulfilling the Promise of "Biased" G Protein-Coupled Receptor Agonism.Anti-inflammatory lipoxin A4 is an endogenous allosteric enhancer of CB1 cannabinoid receptorCarboxypeptidase M augments kinin B1 receptor signaling by conformational crosstalk and enhances endothelial nitric oxide outputAllosteric Modulation of G Protein-Coupled Receptors: An Emerging Approach of Drug Discovery.Practical Strategies and Concepts in GPCR Allosteric Modulator Discovery: Recent Advances with Metabotropic Glutamate ReceptorsAllosteric modulators for the treatment of schizophrenia: targeting glutamatergic networksCarboxypeptidase M is a positive allosteric modulator of the kinin B1 receptor.Functionally biased signalling properties of 7TM receptors - opportunities for drug development for the ghrelin receptor.The spatial structure of cell signaling systems.Minireview: More than just a hammer: ligand "bias" and pharmaceutical discovery.Custom-designed proteins as novel therapeutic tools? The case of arrestins.On the expanding terminology in the GPCR field: the meaning of receptor mosaics and receptor heteromers.The changing world of G protein-coupled receptors: from monomers to dimers and receptor mosaics with allosteric receptor-receptor interactions.Structural insights into adrenergic receptor function and pharmacology.New concepts in pharmacological efficacy at 7TM receptors: IUPHAR review 2.Allosteric interactions at adenosine A(1) and A(3) receptors: new insights into the role of small molecules and receptor dimerization.Allosteric modulation of Class C GPCRs: a novel approach for the treatment of CNS disorders.Diversity and Bias through Receptor-Receptor Interactions in GPCR Heteroreceptor Complexes. Focus on Examples from Dopamine D2 Receptor Heteromerization.Current status of A1 adenosine receptor allosteric enhancers.Structural determinants of allosteric antagonism at metabotropic glutamate receptor 2: mechanistic studies with new potent negative allosteric modulators.Allosteric Modulators of the Class A G Protein Coupled Receptors.
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P2860
'7TM receptor allostery: putting numbers to shapeshifting proteins.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 02 September 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
'7TM receptor allostery: putting numbers to shapeshifting proteins.
@en
'7TM receptor allostery: putting numbers to shapeshifting proteins.
@nl
type
label
'7TM receptor allostery: putting numbers to shapeshifting proteins.
@en
'7TM receptor allostery: putting numbers to shapeshifting proteins.
@nl
prefLabel
'7TM receptor allostery: putting numbers to shapeshifting proteins.
@en
'7TM receptor allostery: putting numbers to shapeshifting proteins.
@nl
P1476
'7TM receptor allostery: putting numbers to shapeshifting proteins.
@en
P2093
Terry P Kenakin
P304
P356
10.1016/J.TIPS.2009.06.007
P577
2009-09-02T00:00:00Z