Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development.
about
Botch promotes neurogenesis by antagonizing NotchCerebral cavernous malformation protein CCM1 inhibits sprouting angiogenesis by activating DELTA-NOTCH signaling.Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sproutingEndothelial Transdifferentiation of Tumor Cells Triggered by the Twist1-Jagged1-KLF4 Axis: Relationship between Cancer Stemness and AngiogenesisTargeting self-renewal pathways in cancer stem cells: clinical implications for cancer therapyImpact of notch signaling on inflammatory responses in cardiovascular disordersNotch: a key regulator of tumor angiogenesis and metastasisDLL4 promotes continuous adult intestinal lacteal regeneration and dietary fat transport.KCTD10 is involved in the cardiovascular system and Notch signaling during early embryonic developmentHeterozygous Loss-of-Function Mutations in DLL4 Cause Adams-Oliver SyndromeEndothelial expression of the Notch ligand Jagged1 is required for vascular smooth muscle developmentEpsin Family of Endocytic Adaptor Proteins as Oncogenic Regulators of Cancer ProgressionBiochemical characterization and cellular effects of CADASIL mutants of NOTCH3Notch signalling in the paraxial mesoderm is most sensitive to reduced Pofut1 levels during early mouse developmentArtery and vein size is balanced by Notch and ephrin B2/EphB4 during angiogenesisVascular endothelial tyrosine phosphatase (VE-PTP)-null mice undergo vasculogenesis but die embryonically because of defects in angiogenesisHOXA13 Is essential for placental vascular patterning and labyrinth endothelial specificationMind bomb-2 is an E3 ligase for Notch ligandAn allelic series uncovers novel roles of the BRCT domain-containing protein PTIP in mouse embryonic vascular developmentThe PIAS-like protein Zimp10 is essential for embryonic viability and proper vascular developmentThe Foxc2 transcription factor regulates angiogenesis via induction of integrin beta3 expressionConditionals by inversion provide a universal method for the generation of conditional allelesTumor angiogenesisMultiscale models of angiogenesisElongation, proliferation & migration differentiate endothelial cell phenotypes and determine capillary sproutingNotch1 activation in mice causes arteriovenous malformations phenocopied by ephrinB2 and EphB4 mutants.Sox17 is indispensable for acquisition and maintenance of arterial identityAutomated discovery of tissue-targeting enhancers and transcription factors from binding motif and gene function data.An obligatory role of mind bomb-1 in notch signaling of mammalian developmentTNF primes endothelial cells for angiogenic sprouting by inducing a tip cell phenotypeFoxc transcription factors directly regulate Dll4 and Hey2 expression by interacting with the VEGF-Notch signaling pathways in endothelial cells.Loss of Notch signalling induced by Dll4 causes arterial calibre reduction by increasing endothelial cell response to angiogenic stimuli.KSHV manipulates Notch signaling by DLL4 and JAG1 to alter cell cycle genes in lymphatic endotheliaActivation of Notch signaling by short-term treatment with Jagged-1 enhances store-operated Ca(2+) entry in human pulmonary arterial smooth muscle cellsNotch and the skeleton.Delta-like ligand 4 plays a critical role in pericyte/vascular smooth muscle cell formation during vasculogenesis and tumor vessel expansion in Ewing's sarcoma.Notch signalling in ischaemia-induced angiogenesis.An inside view: VEGF receptor trafficking and signalingALK1 signaling inhibits angiogenesis by cooperating with the Notch pathway.PET Imaging of Dll4 Expression in Glioblastoma and Colorectal Cancer Xenografts Using (64)Cu-Labeled Monoclonal Antibody 61B
P2860
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P2860
Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh
2004年學術文章
@zh-hant
name
Haploinsufficiency of delta-li ...... rial and vascular development.
@en
Haploinsufficiency of delta-li ...... rial and vascular development.
@nl
type
label
Haploinsufficiency of delta-li ...... rial and vascular development.
@en
Haploinsufficiency of delta-li ...... rial and vascular development.
@nl
prefLabel
Haploinsufficiency of delta-li ...... rial and vascular development.
@en
Haploinsufficiency of delta-li ...... rial and vascular development.
@nl
P2093
P2860
P356
P1476
Haploinsufficiency of delta-li ...... erial and vascular development
@en
P2093
David M Valenzuela
Gavin Thurston
George D Yancopoulos
Hsin Chieh Lin
Irene Noguera
Jocelyn Holash
Melissa G Dominguez
Nicholas W Gale
Niels C Adams
P2860
P304
15949-15954
P356
10.1073/PNAS.0407290101
P407
P577
2004-11-01T00:00:00Z