Constitutively active human Notch1 binds to the transcription factor CBF1 and stimulates transcription through a promoter containing a CBF1-responsive element.
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Overexpression of the Notch target genes Hes in vivo induces lymphoid and myeloid alterationsExpression of Wnt and Notch pathway genes in a pluripotent human embryonal carcinoma cell line and embryonic stem cellActivated notch inhibits myogenic activity of the MADS-Box transcription factor myocyte enhancer factor 2CNotch1 regulates the expression of the multidrug resistance gene ABCC1/MRP1 in cultured cancer cellsEBNA2 and activated Notch induce expression of BATFHES6 acts as a transcriptional repressor in myoblasts and can induce the myogenic differentiation programNon-canonical Notch signaling: emerging role and mechanismInvolvement of Notch1 in the development of mouse mammary tumorsFringe is a glycosyltransferase that modifies NotchComputational models of the Notch network elucidate mechanisms of context-dependent signalingRegulation of mammalian Notch signaling and embryonic development by the protein O-glucosyltransferase RumiRBP-L, a transcription factor related to RBP-JkappaMice lacking both presenilin genes exhibit early embryonic patterning defectsNeuroepithelial body microenvironment is a niche for a distinct subset of Clara-like precursors in the developing airwaysNotch signaling regulates left-right asymmetry determination by inducing Nodal expressionGenomewide expression analysis in zebrafish mind bomb alleles with pancreas defects of different severity identifies putative Notch responsive genesThe Notch-2 gene is regulated by Wnt signaling in cultured colorectal cancer cellsPresenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 productionThe aspartate-257 of presenilin 1 is indispensable for mouse development and production of beta-amyloid peptides through beta-catenin-independent mechanisms.Aberrant expression of genes necessary for neuronal development and Notch signaling in an epileptic mind bomb zebrafish.Functional analysis of a recurrent missense mutation in Notch3 in CADASILSerum induces transcription of Hey1 and Hey2 genes by Alk1 but not Notch signaling in endothelial cellsNotch signaling represses GATA4-induced expression of genes involved in steroid biosynthesisNotch signaling pathway and human placentaThe mammalian transcriptional repressor RBP (CBF1) regulates interleukin-6 gene expression.The abluminal endothelial membrane in neurovascular remodeling in health and disease.Role of Notch signal transduction in Kaposi's sarcoma-associated herpesvirus gene expressionBinding of C/EBP and RBP (CBF1) to overlapping sites regulates interleukin-6 gene expression.Activated mouse Notch1 transactivates Epstein-Barr virus nuclear antigen 2-regulated viral promoters.Notch inhibition of E47 supports the existence of a novel signaling pathwayRoles of the ankyrin repeats and C-terminal region of the mouse notch1 intracellular region.Synergy between suppressor of Hairless and Notch in regulation of Enhancer of split m gamma and m delta expression.Notch1 competes with the amyloid precursor protein for gamma-secretase and down-regulates presenilin-1 gene expression.A site in the complement receptor 2 (CR2/CD21) silencer is necessary for lineage specific transcriptional regulation.Mammalian Notch1 is modified with two unusual forms of O-linked glycosylation found on epidermal growth factor-like modules.Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling.Constitutive transcription of the human interleukin-6 gene by rheumatoid synoviocytes: spontaneous activation of NF-kappaB and CBF1.Regulation of the ERBB-2 promoter by RBPJkappa and NOTCH.Transcriptional roles of CCAAT/enhancer binding protein-beta, nuclear factor-kappaB, and C-promoter binding factor 1 in interleukin (IL)-1beta-induced IL-6 synthesis by human rheumatoid fibroblast-like synoviocytes.MINAR1 is a Notch2-binding protein that inhibits angiogenesis and breast cancer growth.
P2860
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P2860
Constitutively active human Notch1 binds to the transcription factor CBF1 and stimulates transcription through a promoter containing a CBF1-responsive element.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on May 1996
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Constitutively active human No ...... ing a CBF1-responsive element.
@en
Constitutively active human No ...... ing a CBF1-responsive element.
@nl
type
label
Constitutively active human No ...... ing a CBF1-responsive element.
@en
Constitutively active human No ...... ing a CBF1-responsive element.
@nl
prefLabel
Constitutively active human No ...... ing a CBF1-responsive element.
@en
Constitutively active human No ...... ing a CBF1-responsive element.
@nl
P2860
P356
P1476
Constitutively active human No ...... ing a CBF1-responsive element.
@en
P2860
P304
P356
10.1073/PNAS.93.11.5663
P407
P577
1996-05-01T00:00:00Z