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Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling.Alternatives to antibiotics in animal agriculture: an ecoimmunological viewMicrobial biofilm formation: a need to actSelf and nonself: how autophagy targets mitochondria and bacteriaCyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced OligomerizationIdentification of Adjuvantic Activity of Amphotericin B in a Novel, Multiplexed, Poly-TLR/NLR High-Throughput Screen.G-quadruplexes with (4n - 1) guanines in the G-tetrad core: formation of a G-triad·water complex and implication for small-molecule bindingCrosstalk Between Apoptosis and Autophagy: Environmental Genotoxins, Infection, and Innate Immunity.Molecular evolutionary and structural analysis of the cytosolic DNA sensor cGAS and STINGStructure-guided reprogramming of human cGAS dinucleotide linkage specificity.GEMM-I riboswitches from Geobacter sense the bacterial second messenger cyclic AMP-GMPc-di-GMP induction of Dictyostelium cell death requires the polyketide DIF-1An HD-domain phosphodiesterase mediates cooperative hydrolysis of c-di-AMP to affect bacterial growth and virulence.Vibrio cholerae T3SS effector VopE modulates mitochondrial dynamics and innate immune signaling by targeting Miro GTPases.UV Light Potentiates STING (Stimulator of Interferon Genes)-dependent Innate Immune Signaling through Deregulation of ULK1 (Unc51-like Kinase 1)A Conserved Pattern of Primer-Dependent Transcription Initiation in Escherichia coli and Vibrio cholerae Revealed by 5' RNA-seq.The PAMP c-di-AMP Is Essential for Listeria monocytogenes Growth in Rich but Not Minimal Media due to a Toxic Increase in (p)ppGpp. [corrected]The Characterization of Escherichia coli CpdB as a Recombinant Protein Reveals that, besides Having the Expected 3´-Nucleotidase and 2´,3´-Cyclic Mononucleotide Phosphodiesterase Activities, It Is Also Active as Cyclic Dinucleotide PhosphodiesteraseStructural basis for molecular discrimination by a 3',3'-cGAMP sensing riboswitchHybrid promiscuous (Hypr) GGDEF enzymes produce cyclic AMP-GMP (3', 3'-cGAMP)Tn-Seq analysis of Vibrio cholerae intestinal colonization reveals a role for T6SS-mediated antibacterial activity in the hostSTING, nanoparticles, autoimmune disease and cancer: a novel paradigm for immunotherapy?Mammalian designer cells: Engineering principles and biomedical applications.Structural biology: a 'funny' cyclic dinucleotide receptor.Autophagy in Dictyostelium: Mechanisms, regulation and disease in a simple biomedical model.Cyclic di-GMP acts as a cell cycle oscillator to drive chromosome replication.Discovery of the Second Messenger Cyclic di-GMP.Cyclic Dinucleotides in the Scope of the Mammalian Immune System.Group B Streptococcus Degrades Cyclic-di-AMP to Modulate STING-Dependent Type I Interferon Production.RNA-Based Fluorescent Biosensors for Live Cell Imaging of Second Messenger Cyclic di-AMP.Crystal structure of the novel di-nucleotide cyclase from Vibrio cholerae (DncV) responsible for synthesizing a hybrid cyclic GMP-AMP.STING-Dependent Signaling Underlies IL-10 Controlled Inflammatory Colitis.ALK is a therapeutic target for lethal sepsis.Engineered trivalent immunogen adjuvanted with a STING agonist confers protection against Trypanosoma cruzi infection.The cytosolic sensor STING is required for intestinal homeostasis and control of inflammation.Chemiluminescent Biosensors for Detection of Second Messenger Cyclic di-GMP.A novel transcript isoform of STING that sequesters cGAMP and dominantly inhibits innate nucleic acid sensing.Cyclic di-AMP regulation of osmotic homeostasis is essential in Group B Streptococcus.MPYS/STING-mediated TNF-α, not type I IFN, is essential for the mucosal adjuvant activity of (3'-5')-cyclic-di-guanosine-monophosphate in vivo.Interplay between Cellular Metabolism and Cytokine Responses during Viral Infection
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on August 2013
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Cyclic dinucleotides and the innate immune response.
@en
Cyclic dinucleotides and the innate immune response.
@nl
type
label
Cyclic dinucleotides and the innate immune response.
@en
Cyclic dinucleotides and the innate immune response.
@nl
prefLabel
Cyclic dinucleotides and the innate immune response.
@en
Cyclic dinucleotides and the innate immune response.
@nl
P2860
P1433
P1476
Cyclic dinucleotides and the innate immune response.
@en
P2093
John J Mekalanos
Olga Danilchanka
P2860
P304
P356
10.1016/J.CELL.2013.08.014
P407
P577
2013-08-01T00:00:00Z