Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway
about
Harnessing Mechanistic Knowledge on Beneficial Versus Deleterious IFN-I Effects to Design Innovative Immunotherapies Targeting Cytokine Activity to Specific Cell TypesSingle nucleotide polymorphisms of human STING can affect innate immune response to cyclic dinucleotidesMitochondrial DNA stress primes the antiviral innate immune responseAkirin2 is critical for inducing inflammatory genes by bridging IκB-ζ and the SWI/SNF complexStructural and functional analysis of MiD51, a dynamin receptor required for mitochondrial fissionAncient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling.IFI16 DNA sensor is required for death of lymphoid CD4 T cells abortively infected with HIVStress Beyond Translation: Poxviruses and MoreHuman Oncogenic Herpesvirus and Post-translational Modifications - Phosphorylation and SUMOylationImmune Activation in the Liver by Nucleic AcidsCytosolic Innate Immune Sensing and Signaling upon InfectionRoles for retrotransposon insertions in human diseaseUbiquitin signaling in immune responsesAlum: an old dog with new tricksSTING: infection, inflammation and cancerAn unexpected role for RNA-sensing toll-like receptors in a murine model of DNA accrualThe Next Hurdle in Cancer Immunotherapy: Overcoming the Non-T-Cell-Inflamed Tumor MicroenvironmentCloak and Dagger: Alternative Immune Evasion and Modulation Strategies of PoxvirusesSensors of Infection: Viral Nucleic Acid PRRs in FishThe role of dendritic cells in immunity against primary herpes simplex virus infectionsCyclic di-GMP: the first 25 years of a universal bacterial second messengerDNA vaccines: a simple DNA sensing matter?Cellular self-defense: how cell-autonomous immunity protects against pathogensRecognition of cytosolic DNA by cGAS and other STING-dependent sensorsMicrobial biofilm formation: a need to actThe STING pathway and the T cell-inflamed tumor microenvironmentTargeting the innate immune system as immunotherapy for acute myeloid leukemiaThe enemy within: endogenous retroelements and autoimmune diseaseCrosstalk between Mycobacterium tuberculosis and the host cellNucleic acids and endosomal pattern recognition: how to tell friend from foe?TLRs and interferons: a central paradigm in autoimmunityRationale, progress and development of vaccines utilizing STING-activating cyclic dinucleotide adjuvantsSTAT2 signaling and dengue virus infectionMetabolomics and systems pharmacology: why and how to model the human metabolic network for drug discoverySpecies-specific detection of the antiviral small-molecule compound CMA by STINGCyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP SynthaseStructure of Human cGAS Reveals a Conserved Family of Second-Messenger Enzymes in Innate ImmunityStructural mechanism of cytosolic DNA sensing by cGASStructural Insights into the Functions of TBK1 in Innate Antimicrobial ImmunityCyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING
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Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway
description
2013 nî lūn-bûn
@nan
2013 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Cyclic GMP-AMP synthase is a c ...... the type I interferon pathway
@ast
Cyclic GMP-AMP synthase is a c ...... the type I interferon pathway
@en
Cyclic GMP-AMP synthase is a c ...... the type I interferon pathway
@en-gb
Cyclic GMP-AMP synthase is a c ...... the type I interferon pathway
@nl
type
label
Cyclic GMP-AMP synthase is a c ...... the type I interferon pathway
@ast
Cyclic GMP-AMP synthase is a c ...... the type I interferon pathway
@en
Cyclic GMP-AMP synthase is a c ...... the type I interferon pathway
@en-gb
Cyclic GMP-AMP synthase is a c ...... the type I interferon pathway
@nl
prefLabel
Cyclic GMP-AMP synthase is a c ...... the type I interferon pathway
@ast
Cyclic GMP-AMP synthase is a c ...... the type I interferon pathway
@en
Cyclic GMP-AMP synthase is a c ...... the type I interferon pathway
@en-gb
Cyclic GMP-AMP synthase is a c ...... the type I interferon pathway
@nl
P2093
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Cyclic GMP-AMP synthase is a c ...... the type I interferon pathway
@en
P2093
Xiang Chen
Zhijian J Chen
P2860
P304
P3181
P356
10.1126/SCIENCE.1232458
P407
P50
P577
2012-12-20T00:00:00Z