The Wt1+/R394W mouse displays glomerulosclerosis and early-onset renal failure characteristic of human Denys-Drash syndrome.
about
Deducing the stage of origin of Wilms' tumours from a developmental series of Wt1-mutant miceHemolytic uremic syndrome as the presenting manifestation of WT1 mutation and Denys-Drash syndrome: a case report.Transcriptomic analysis brings new insight into the biological role of the prion protein during mouse embryogenesisMolecular genetics of Müllerian duct formation, regression and differentiationDisruption of genital ridge development causes aberrant primordial germ cell proliferation but does not affect their directional migrationThe Wilms tumor gene, Wt1, is critical for mouse spermatogenesis via regulation of sertoli cell polarity and is associated with non-obstructive azoospermia in humans.The Wilms tumor gene, Wt1, is required for Sox9 expression and maintenance of tubular architecture in the developing testis.The yin and yang of kidney development and Wilms' tumorsA novel missense mutation of Wilms' Tumor 1 causes autosomal dominant FSGS.New insights into the function of the Wilms tumor suppressor gene WT1 in podocytes.Educational paper: the podocytopathies.Engineering subtle targeted mutations into the mouse genome.Wt1 in the kidney--a tale in mouse models.Ectopic notch activation in developing podocytes causes glomerulosclerosis.Wt1 is involved in leydig cell steroid hormone biosynthesis by regulating paracrine factor expression in mice.Nephrin Tyrosine Phosphorylation Is Required to Stabilize and Restore Podocyte Foot Process Architecture.WT1 Is Necessary for the Proliferation and Migration of Cells of Renin Lineage Following Kidney Podocyte Depletion.Wt1 functions in ovarian follicle development by regulating granulosa cell differentiation.A familial WT1 mutation associated with incomplete Denys-Drash syndrome.Sirolimus interacts with pathways essential for podocyte integrity.Clinical Aspects of WT1 and the Kidney.Knock-in of the R394W mutation causes MDS and cooperates with to drive aggressive myeloid neoplasms in mice
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P2860
The Wt1+/R394W mouse displays glomerulosclerosis and early-onset renal failure characteristic of human Denys-Drash syndrome.
description
2004 nî lūn-bûn
@nan
2004年の論文
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2004年学术文章
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2004年学术文章
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2004年学术文章
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2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
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name
The Wt1+/R394W mouse displays ...... of human Denys-Drash syndrome.
@en
The Wt1+/R394W mouse displays ...... of human Denys-Drash syndrome.
@nl
type
label
The Wt1+/R394W mouse displays ...... of human Denys-Drash syndrome.
@en
The Wt1+/R394W mouse displays ...... of human Denys-Drash syndrome.
@nl
prefLabel
The Wt1+/R394W mouse displays ...... of human Denys-Drash syndrome.
@en
The Wt1+/R394W mouse displays ...... of human Denys-Drash syndrome.
@nl
P2093
P2860
P1476
The Wt1+/R394W mouse displays ...... of human Denys-Drash syndrome.
@en
P2093
Guizhi Sun
Jian Min Deng
Malini Udtha
Nelson G Ordonez
Richard R Behringer
Sourindra Maiti
Vicki Huff
P2860
P304
P356
10.1128/MCB.24.22.9899-9910.2004
P407
P577
2004-11-01T00:00:00Z