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Protein tyrosine kinase 6 regulates mammary gland tumorigenesis in mouse models.

Protein tyrosine kinase 6 regulates mammary gland tumorigenesis in mouse models.

http://www.wikidata.org/entity/Q37614521

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Cancer-Associated Mutations in Breast Tumor Kinase/PTK6 Differentially Affect Enzyme Activity and Substrate Recognition.PTK6/BRK is expressed in the normal mammary gland and activated at the plasma membrane in breast tumors.Pathways driving the endocytosis of mutant and wild-type EGFR in cancer.Sphingosine-1-phosphate induces the migration of thyroid follicular carcinoma cells through the microRNA-17/PTK6/ERK1/2 pathway Protein tyrosine kinase 6 promotes ERBB2-induced mammary gland tumorigenesis in the mouse.Protein Tyrosine Kinase 6 Regulates UVB-Induced Signaling and Tumorigenesis in Mouse Skin.Caveolin-1 regulates cancer cell metabolism via scavenging Nrf2 and suppressing MnSOD-driven glycolysis.Additive impact of HER2-/PTK6-RNAi on interactions with HER3 or IGF-1R leads to reduced breast cancer progression in vivo.

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Protein tyrosine kinase 6 regulates mammary gland tumorigenesis in mouse models.

http://www.wikidata.org/entity/Q37614521

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

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scientific article published on 09 December 2013

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

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vědecký článek

@cs

name

Protein tyrosine kinase 6 regulates mammary gland tumorigenesis in mouse models.

@en

Protein tyrosine kinase 6 regulates mammary gland tumorigenesis in mouse models.

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type

label

Protein tyrosine kinase 6 regulates mammary gland tumorigenesis in mouse models.

@en

Protein tyrosine kinase 6 regulates mammary gland tumorigenesis in mouse models.

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prefLabel

Protein tyrosine kinase 6 regulates mammary gland tumorigenesis in mouse models.

@en

Protein tyrosine kinase 6 regulates mammary gland tumorigenesis in mouse models.

@nl

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Protein tyrosine kinase 6 regulates mammary gland tumorigenesis in mouse models

@en

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H Xie

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M Peng

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R R Franks

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S M Ball-Kell

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Signal transducer and activator of transcription 5b: a new target of breast tumor kinase/protein tyrosine kinase 6

Identification of STAT3 as a specific substrate of breast tumor kinase

Cloning and characterisation of cDNAs encoding a novel non-receptor tyrosine kinase, brk, expressed in human breast tumours

Brk activates rac1 and promotes cell migration and invasion by phosphorylating paxillin

Mouse models for breast cancer

Protein-tyrosine kinase 6 promotes peripheral adhesion complex formation and cell migration by phosphorylating p130 CRK-associated substrate

Protein tyrosine kinase 6 directly phosphorylates AKT and promotes AKT activation in response to epidermal growth factor

Brk is coamplified with ErbB2 to promote proliferation in breast cancer

STAP-2 is phosphorylated at tyrosine-250 by Brk and modulates Brk-mediated STAT3 activation

Expression of the BRK tyrosine kinase in mammary epithelial cells enhances the coupling of EGF signalling to PI 3-kinase and Akt, via erbB3 phosphorylation

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e81

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scholarly article

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10.1038/ONCSIS.2013.43

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2

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Angela L. Tyner

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2013-12-09T00:00:00Z

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