A region of the insulin receptor important for ligand binding (residues 450-601) is recognized by patients' autoimmune antibodies and inhibitory monoclonal antibodies.
about
Cloning and characterisation of Schistosoma japonicum insulin receptorsSelection of an RNA molecule that mimics a major autoantigenic epitope of human insulin receptor.High-affinity insulin binding: insulin interacts with two receptor ligand binding sites.Characterization of the endogenous insulin receptor-related receptor in neuroblastomas.Structure of the insulin receptor ectodomain reveals a folded-over conformation.Flexibility in the insulin receptor ectodomain enables docking of insulin in crystallographic conformation observed in a hormone-bound microreceptor.Identification of Host Insulin Binding Sites on Schistosoma japonicum Insulin ReceptorsIsolation of a nuclease-resistant decoy RNA that selectively blocks autoantibody binding to insulin receptors on human lymphocytes.A peptide derived from an extracellular domain selectively inhibits receptor internalization: target sequences on insulin and insulin-like growth factor 1 receptors.Investigation of the mechanism of the dominant negative effect of mutations in the tyrosine kinase domain of the insulin receptor.The Drosophila insulin receptor contains a novel carboxyl-terminal extension likely to play an important role in signal transduction.Dimeric fragment of the insulin receptor alpha-subunit binds insulin with full holoreceptor affinity.Expression and characterization of a 70-kDa fragment of the insulin receptor that binds insulin. Minimizing ligand binding domain of the insulin receptor.Fusion of insulin receptor ectodomains to immunoglobulin constant domains reproduces high-affinity insulin binding in vitro.Theoretical and computational studies of peptides and receptors of the insulin family.Characterization of the functional insulin binding epitopes of the full-length insulin receptor.The Drosophila insulin receptor homolog: a gene essential for embryonic development encodes two receptor isoforms with different signaling potential.Identification of common ligand binding determinants of the insulin and insulin-like growth factor 1 receptors. Insights into mechanisms of ligand binding.A novel monoclonal antibody dependent on domain 5 of the platelet-derived growth factor beta receptor inhibits ligand binding and receptor activation.High density insulin receptor-positive diabetogenic T lymphocytes in nonobese diabetic mice are memory cells.All-atom structural models of insulin binding to the insulin receptor in the presence of a tandem hormone-binding element.An Insulin Receptor Mutant (Asp707→ Ala), Involved in Leprechaunism, Is Processed and Transported to the Cell Surface but Unable to Bind InsulinAn Investigation of the Ligand Binding Properties and Negative Cooperativity of Soluble Insulin-like Growth Factor Receptors
P2860
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P2860
A region of the insulin receptor important for ligand binding (residues 450-601) is recognized by patients' autoimmune antibodies and inhibitory monoclonal antibodies.
description
1991 nî lūn-bûn
@nan
1991年の論文
@ja
1991年学术文章
@wuu
1991年学术文章
@zh-cn
1991年学术文章
@zh-hans
1991年学术文章
@zh-my
1991年学术文章
@zh-sg
1991年學術文章
@yue
1991年學術文章
@zh
1991年學術文章
@zh-hant
name
A region of the insulin recept ...... ibitory monoclonal antibodies.
@en
A region of the insulin receptor important for ligand binding
@nl
type
label
A region of the insulin recept ...... ibitory monoclonal antibodies.
@en
A region of the insulin receptor important for ligand binding
@nl
prefLabel
A region of the insulin recept ...... ibitory monoclonal antibodies.
@en
A region of the insulin receptor important for ligand binding
@nl
P2860
P356
P1476
A region of the insulin recept ...... ibitory monoclonal antibodies.
@en
P2093
P2860
P304
P356
10.1073/PNAS.88.21.9858
P407
P577
1991-11-01T00:00:00Z