Fusion of insulin receptor ectodomains to immunoglobulin constant domains reproduces high-affinity insulin binding in vitro.
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The A-chain of insulin contacts the insert domain of the insulin receptor. Photo-cross-linking and mutagenesis of a diabetes-related creviceStructural Basis for Negative Cooperativity in Growth Factor Binding to an EGF ReceptorInsulin/receptor binding: the last piece of the puzzle? What recent progress on the structure of the insulin/receptor complex tells us (or not) about negative cooperativity and activation.High-affinity insulin binding: insulin interacts with two receptor ligand binding sites.IGF1R blockade with ganitumab results in systemic effects on the GH-IGF axis in mice.Complex relationship between ligand binding and dimerization in the epidermal growth factor receptor.How IGF-1 activates its receptor.Folding of insulin receptor monomers is facilitated by the molecular chaperones calnexin and calreticulin and impaired by rapid dimerization.Ligand-induced ErbB receptor dimerization.Dimeric fragment of the insulin receptor alpha-subunit binds insulin with full holoreceptor affinity.High affinity insulin binding by soluble insulin receptor extracellular domain fused to a leucine zipper.Expression and characterization of a 70-kDa fragment of the insulin receptor that binds insulin. Minimizing ligand binding domain of the insulin receptor.Theoretical and computational studies of peptides and receptors of the insulin family.Congenital insulin resistance associated with a conformational alteration in a conserved beta-sheet in the insulin receptor L1 domain.A novel approach to identify two distinct receptor binding surfaces of insulin-like growth factor II.Hormone-triggered conformational changes within the insulin-receptor ectodomain: requirement for transmembrane anchors.Peptides identify the critical hotspots involved in the biological activation of the insulin receptor.All-atom structural models of insulin binding to the insulin receptor in the presence of a tandem hormone-binding element.An Investigation of the Ligand Binding Properties and Negative Cooperativity of Soluble Insulin-like Growth Factor Receptors
P2860
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P2860
Fusion of insulin receptor ectodomains to immunoglobulin constant domains reproduces high-affinity insulin binding in vitro.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
1996年學術文章
@zh
1996年學術文章
@zh-hant
name
Fusion of insulin receptor ect ...... nity insulin binding in vitro.
@en
type
label
Fusion of insulin receptor ect ...... nity insulin binding in vitro.
@en
prefLabel
Fusion of insulin receptor ect ...... nity insulin binding in vitro.
@en
P2093
P2860
P356
P1476
Fusion of insulin receptor ect ...... nity insulin binding in vitro.
@en
P2093
P2860
P304
19367-19375
P356
10.1074/JBC.271.32.19367
P407
P577
1996-08-01T00:00:00Z