Hijacking the chromatin remodeling machinery: impact of SWI/SNF perturbations in cancer.
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The spectrum of SWI/SNF mutations, ubiquitous in human cancersResidual complexes containing SMARCA2 (BRM) underlie the oncogenic drive of SMARCA4 (BRG1) mutationCARM1 methylates chromatin remodeling factor BAF155 to enhance tumor progression and metastasisConvergent structural alterations define SWItch/Sucrose NonFermentable (SWI/SNF) chromatin remodeler as a central tumor suppressive complex in pancreatic cancerSWI/SNF chromatin remodeling complexes and cancerThe BAH domain of Rsc2 is a histone H3 binding domainThe nuclear localization of SWI/SNF proteins is subjected to oxygen regulation.Chromatin particle spectrum analysis: a method for comparative chromatin structure analysis using paired-end mode next-generation DNA sequencing.SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2Frequent mutations of chromatin remodeling gene ARID1A in ovarian clear cell carcinomaSWI/SNF and Asf1 independently promote derepression of the DNA damage response genes under conditions of replication stressThe E3 ubiquitin ligase activity of Trip12 is essential for mouse embryogenesisSomatic mutations in the chromatin remodeling gene ARID1A occur in several tumor types.Molecular classifications of gastric cancers: Novel insights and possible future applications.Epigenetic regulation of epithelial-mesenchymal transitionDiverse roles and interactions of the SWI/SNF chromatin remodeling complex revealed using global approaches.Screening for inhibitors of an essential chromatin remodeler in mouse embryonic stem cells by monitoring transcriptional regulation.Identification of new genetic susceptibility loci for breast cancer through consideration of gene-environment interactions.The BRG1 chromatin remodeler protects against ovarian cysts, uterine tumors, and mammary tumors in a lineage-specific manner.BRG1 co-localizes with DNA replication factors and is required for efficient replication fork progressionProteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy.BRG1/SMARCA4 inactivation promotes non-small cell lung cancer aggressiveness by altering chromatin organization.Identification of a STAT5 target gene, Dpf3, provides novel insights in chronic lymphocytic leukemia.ARID1A expression in gastric adenocarcinoma: clinicopathological significance and correlation with DNA mismatch repair status.SNF5 reexpression in malignant rhabdoid tumors regulates transcription of target genes by recruitment of SWI/SNF complexes and RNAPII to the transcription start site of their promoters.Genomic analyses of gynaecologic carcinosarcomas reveal frequent mutations in chromatin remodelling genesBRG1 mutations found in human cancer cell lines inactivate Rb-mediated cell-cycle arrestIdentification of a core member of the SWI/SNF complex, BAF155/SMARCC1, as a human tumor suppressor gene.Chromatin Remodelers: From Function to Dysfunction.Cancer epigenetics: above and beyondThe role of components of the chromatin modification machinery in carcinogenesis of clear cell carcinoma of the ovary (Review)MicroRNA-7 Compromises p53 Protein-dependent Apoptosis by Controlling the Expression of the Chromatin Remodeling Factor SMARCD1.The clinical significance of SWI/SNF complex in pancreatic cancer.Functional Interplay of Two Paralogs Encoding SWI/SNF Chromatin-Remodeling Accessory Subunits During Caenorhabditis elegans DevelopmentIdentification of novel CHD1-associated collaborative alterations of genomic structure and functional assessment of CHD1 in prostate cancer.Swi/Snf chromatin remodeling/tumor suppressor complex establishes nucleosome occupancy at target promotersA role for Mediator complex subunit MED13L in Rb/E2F-induced growth arrestNucleosome remodeling and epigenetics.A comparative genomic approach for identifying synthetic lethal interactions in human cancer.miR-31 targets ARID1A and enhances the oncogenicity and stemness of head and neck squamous cell carcinoma.
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Hijacking the chromatin remodeling machinery: impact of SWI/SNF perturbations in cancer.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
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scientific article published on 20 October 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Hijacking the chromatin remodeling machinery: impact of SWI/SNF perturbations in cancer.
@en
Hijacking the chromatin remodeling machinery: impact of SWI/SNF perturbations in cancer.
@nl
type
label
Hijacking the chromatin remodeling machinery: impact of SWI/SNF perturbations in cancer.
@en
Hijacking the chromatin remodeling machinery: impact of SWI/SNF perturbations in cancer.
@nl
prefLabel
Hijacking the chromatin remodeling machinery: impact of SWI/SNF perturbations in cancer.
@en
Hijacking the chromatin remodeling machinery: impact of SWI/SNF perturbations in cancer.
@nl
P2860
P1433
P1476
Hijacking the chromatin remodeling machinery: impact of SWI/SNF perturbations in cancer.
@en
P2093
Bernard Weissman
P2860
P304
P356
10.1158/0008-5472.CAN-09-2166
P407
P577
2009-10-20T00:00:00Z