Behavioral, neurochemical, and pathologic alterations in bacterial artificial chromosome transgenic G2019S leucine-rich repeated kinase 2 rats.
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Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in miceLeucine-rich Repeat Kinase 2 (LRRK2) Pharmacological Inhibition Abates α-Synuclein Gene-induced Neurodegeneration.LRRK2 BAC transgenic rats develop progressive, L-DOPA-responsive motor impairment, and deficits in dopamine circuit functionLRRK2 mutations and neurotoxicant susceptibilityThe function of orthologues of the human Parkinson's disease gene LRRK2 across species: implications for disease modelling in preclinical research.Age-dependent dopamine transporter dysfunction and Serine129 phospho-α-synuclein overload in G2019S LRRK2 mice.Models of LRRK2-Associated Parkinson's Disease.Parkinson disease-associated LRRK2 G2019S transgene disrupts marrow myelopoiesis and peripheral Th17 response.The G2019S LRRK2 mutation increases myeloid cell chemotactic responses and enhances LRRK2 binding to actin-regulatory proteins.From the Cover: Alterations in Optineurin Expression and Localization in Pre-clinical Parkinson's Disease ModelsMechanisms of Mutant LRRK2 Neurodegeneration.New developments in genetic rat models of Parkinson's disease.Alterations in the nigrostriatal dopamine system after acute systemic PhIP exposure.Probiotics Affect One-Carbon Metabolites and Catecholamines in a Genetic Rat Model of Depression.Dopamine D2 receptor-mediated neuroprotection in a G2019S Lrrk2 genetic model of Parkinson's disease.Synthetic alpha-synuclein fibrils cause mitochondrial impairment and selective dopamine neurodegeneration in part via iNOS-mediated nitric oxide production.Interaction of LRRK2 and α-Synuclein in Parkinson's Disease.
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Behavioral, neurochemical, and pathologic alterations in bacterial artificial chromosome transgenic G2019S leucine-rich repeated kinase 2 rats.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 15 July 2014
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Behavioral, neurochemical, and ...... e-rich repeated kinase 2 rats.
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Behavioral, neurochemical, and ...... e-rich repeated kinase 2 rats.
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type
label
Behavioral, neurochemical, and ...... e-rich repeated kinase 2 rats.
@en
Behavioral, neurochemical, and ...... e-rich repeated kinase 2 rats.
@nl
prefLabel
Behavioral, neurochemical, and ...... e-rich repeated kinase 2 rats.
@en
Behavioral, neurochemical, and ...... e-rich repeated kinase 2 rats.
@nl
P2860
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P1476
Behavioral, neurochemical, and ...... e-rich repeated kinase 2 rats.
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P2093
Jang-Won Lee
Roberto Di Maio
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P304
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10.1016/J.NEUROBIOLAGING.2014.07.011
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2014-07-15T00:00:00Z