C-terminus determinants for Mg2+ and polyamine block of the inward rectifier K+ channel IRK1.
about
Inwardly rectifying K+ channel Kir7.1 is highly expressed in thyroid follicular cells, intestinal epithelial cells and choroid plexus epithelial cells: implication for a functional coupling with Na+,K+-ATPaseA glutamate residue at the C terminus regulates activity of inward rectifier K+ channels: implication for Andersen's syndrome.Inward rectifiers and their regulation by endogenous polyaminesCrystal Structure of the Eukaryotic Strong Inward-Rectifier K+ Channel Kir2.2 at 3.1 A ResolutionPhysical determinants of strong voltage sensitivity of K+ channel blockAn inward rectifier K(+) channel at the basolateral membrane of the mouse distal convoluted tubule: similarities with Kir4-Kir5.1 heteromeric channelsCytoplasmic polyamines as permeant blockers and modulators of the voltage-gated sodium channel.Control of rectification and permeation by two distinct sites after the second transmembrane region in Kir2.1 K+ channelSeparable effects of human Kvbeta1.2 N- and C-termini on inactivation and expression of human Kv1.4Magnesium modulates ROMK channel-mediated potassium secretionMolecular diversity and regulation of renal potassium channels.Inward rectification in KATP channels: a pH switch in the pore.Interaction of permeant and blocking ions in cloned inward-rectifier K+ channelsStructural determinants of gating in inward-rectifier K+ channels.Ion selectivity and current saturation in inward-rectifier K+ channelsMulti-ion distributions in the cytoplasmic domain of inward rectifier potassium channels.Natural and synthetic modulators of SK (K(ca)2) potassium channels inhibit magnesium-dependent activity of the kinase-coupled cation channel TRPM7Functional roles of charged amino acid residues on the wall of the cytoplasmic pore of Kir2.1.Ring of negative charge in BK channels facilitates block by intracellular Mg2+ and polyamines through electrostatics.Interactions of external K+ and internal blockers in a weak inward-rectifier K+ channel.Novel gating mechanism of polyamine block in the strong inward rectifier K channel Kir2.1.Mechanism of the voltage sensitivity of IRK1 inward-rectifier K+ channel block by the polyamine spermine.Block of the Kir2.1 channel pore by alkylamine analogues of endogenous polyamines.Tuning the voltage dependence of tetraethylammonium block with permeant ions in an inward-rectifier K+ channel.Ser165 in the second transmembrane region of the Kir2.1 channel determines its susceptibility to blockade by intracellular Mg2+.Interaction mechanisms between polyamines and IRK1 inward rectifier K+ channels.Cytoplasmic amino and carboxyl domains form a wide intracellular vestibule in an inwardly rectifying potassium channel.Permeation properties of inward-rectifier potassium channels and their molecular determinantsCarboxy-terminal determinants of conductance in inward-rectifier K channelsSpermine block of the strong inward rectifier potassium channel Kir2.1: dual roles of surface charge screening and pore block.A synergistic blocking effect of Mg²⁺ and spermine on the inward rectifier K⁺ (Kir2.1) channel pore.Coupled ion movement underlies rectification in an inward-rectifier K+ channel.Long-pore electrostatics in inward-rectifier potassium channels.Two modes of polyamine block regulating the cardiac inward rectifier K+ current IK1 as revealed by a study of the Kir2.1 channel expressed in a human cell line.Low-affinity spermine block mediating outward currents through Kir2.1 and Kir2.2 inward rectifier potassium channels.Interactions of polyamines with ion channelsEvidence for sequential ion-binding loci along the inner pore of the IRK1 inward-rectifier K+ channel.Mechanism of rectification in inward-rectifier K+ channels.Inward rectification by polyamines in mouse Kir2.1 channels: synergy between blocking components.The effects of spermine on the accessibility of residues in the M2 segment of Kir2.1 channels expressed in Xenopus oocytes.
P2860
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P2860
C-terminus determinants for Mg2+ and polyamine block of the inward rectifier K+ channel IRK1.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年学术文章
@wuu
1995年学术文章
@zh-cn
1995年学术文章
@zh-hans
1995年学术文章
@zh-my
1995年学术文章
@zh-sg
1995年學術文章
@yue
1995年學術文章
@zh
1995年學術文章
@zh-hant
name
C-terminus determinants for Mg ...... ard rectifier K+ channel IRK1.
@en
C-terminus determinants for Mg ...... ard rectifier K+ channel IRK1.
@nl
type
label
C-terminus determinants for Mg ...... ard rectifier K+ channel IRK1.
@en
C-terminus determinants for Mg ...... ard rectifier K+ channel IRK1.
@nl
prefLabel
C-terminus determinants for Mg ...... ard rectifier K+ channel IRK1.
@en
C-terminus determinants for Mg ...... ard rectifier K+ channel IRK1.
@nl
P2093
P2860
P1433
P1476
C-terminus determinants for Mg ...... ard rectifier K+ channel IRK1.
@en
P2093
M Taglialatela
P2860
P304
P407
P577
1995-11-01T00:00:00Z