Immunoglobulin gene transcription ceases upon deletion of a distant enhancer.
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The origin of a developmentally regulated Igh replicon is located near the border of regulatory domains for Igh replication and expressionT-bet regulates IgG class switching and pathogenic autoantibody productionChromatin architecture near a potential 3' end of the igh locus involves modular regulation of histone modifications during B-Cell development and in vivo occupancy at CTCF sites.Transgenes of the mouse immunoglobulin heavy chain locus, lacking distal elements in the 3' regulatory region, are impaired for class switch recombinationRecombination and transcription of the endogenous Ig heavy chain locus is effected by the Ig heavy chain intronic enhancer core region in the absence of the matrix attachment regions.Homologous elements hs3a and hs3b in the 3' regulatory region of the murine immunoglobulin heavy chain (Igh) locus are both dispensable for class-switch recombination.Dynamic changes in binding of immunoglobulin heavy chain 3' regulatory region to protein factors during class switching.Enhancement of antibody class-switch recombination by the cumulative activity of four separate elements.Comparison of identical and functional Igh alleles reveals a nonessential role for Eμ in somatic hypermutation and class-switch recombination2,3,7,8-tetrachlorodibenzo-p-dioxin induces transcriptional activity of the human polymorphic hs1,2 enhancer of the 3'Igh regulatory regionHydrogen peroxide modulates immunoglobulin expression by targeting the 3'Igh regulatory region through an NFκB-dependent mechanismThe 3' end of the heavy chain constant region locus enhances germline transcription and switch recombination of the four gamma genes.Class switching in B cells lacking 3' immunoglobulin heavy chain enhancers.Regulation of the replication of the murine immunoglobulin heavy chain gene locus: evaluation of the role of the 3' regulatory region.Loss of an Igκ gene enhancer in mature B cells results in rapid gene silencing and partial reversible dedifferentiation.Role of the Igh intronic enhancer Eμ in clonal selection at the pre-B to immature B cell transition.Transcription of a productively rearranged Ig VDJC alpha does not require the presence of HS4 in the IgH 3' regulatory regionConcerted repression of an immunoglobulin heavy-chain enhancer, 3' alpha E(hs1,2)Epigenetic Regulation of Individual Modules of the immunoglobulin heavy chain locus 3' Regulatory Region.Cis-acting regulatory sequences promote high-frequency gene conversion between repeated sequences in mammalian cells.Expression of the (recombinant) endogenous immunoglobulin heavy-chain locus requires the intronic matrix attachment regions.A T cell controlled molecular pathway regulating the IgH locus: CD40-mediated activation of the IgH 3' enhancer.Germline deletion of Igh 3' regulatory region elements hs 5, 6, 7 (hs5-7) affects B cell-specific regulation, rearrangement, and insulation of the Igh locus.Using altered specificity Oct-1 and Oct-2 mutants to analyze the regulation of immunoglobulin gene transcription.
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P2860
Immunoglobulin gene transcription ceases upon deletion of a distant enhancer.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on December 1995
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Immunoglobulin gene transcription ceases upon deletion of a distant enhancer.
@en
Immunoglobulin gene transcription ceases upon deletion of a distant enhancer.
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label
Immunoglobulin gene transcription ceases upon deletion of a distant enhancer.
@en
Immunoglobulin gene transcription ceases upon deletion of a distant enhancer.
@nl
prefLabel
Immunoglobulin gene transcription ceases upon deletion of a distant enhancer.
@en
Immunoglobulin gene transcription ceases upon deletion of a distant enhancer.
@nl
P2093
P2860
P1433
P1476
Immunoglobulin gene transcription ceases upon deletion of a distant enhancer
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P2093
P2860
P304
P356
10.1002/J.1460-2075.1995.TB00313.X
P407
P577
1995-12-01T00:00:00Z