Specific NEMO mutations impair CD40-mediated c-Rel activation and B cell terminal differentiation. - Wikidata - wikimedia - TriplyDB

Specific NEMO mutations impair CD40-mediated c-Rel activation and B cell terminal differentiation.

Specific NEMO mutations impair CD40-mediated c-Rel activation and B cell terminal differentiation.

http://www.wikidata.org/entity/Q37628194

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SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression Regulation of aicda expression and AID activity: relevance to somatic hypermutation and class switch DNA recombination Humoral immunodeficiency : awareness for better support The diagnostic approach to monogenic very early onset inflammatory bowel disease Educational paper: primary antibody deficiencies Persistent systemic inflammation and atypical enterocolitis in patients with NEMO syndrome.A custom 148 gene-based resequencing chip and the SNP explorer software: new tools to study antibody deficiency.Novel INHAT repressor (NIR) is required for early lymphocyte development.The NEMO mutation creating the most-upstream premature stop codon is hypomorphic because of a reinitiation of translation.Viral double-stranded RNA triggers Ig class switching by activating upper respiratory mucosa B cells through an innate TLR3 pathway involving BAFF.IKBKG (nuclear factor-kappa B essential modulator) mutation can be associated with opportunistic infection without impairing Toll-like receptor function.Dendritic cells from humans with hypomorphic mutations in IKBKG/NEMO have impaired mitogen-activated protein kinase activity.NEMO is a key component of NF-κB- and IRF-3-dependent TLR3-mediated immunity to herpes simplex virus.Novel sequencing-based strategies for high-throughput discovery of genetic mutations underlying inherited antibody deficiency disorders Partial immune reconstitution of X-linked hyper IgM syndrome with recombinant CD40 ligand Defective nuclear IKKα function in patients with ectodermal dysplasia with immune deficiency.New mechanism of X-linked anhidrotic ectodermal dysplasia with immunodeficiency: impairment of ubiquitin binding despite normal folding of NEMO protein.c-Rel plays a key role in deficient activation of B cells from a non-X-linked hyper-IgM patient.Impaired dendritic-cell function in ectodermal dysplasia with immune deficiency is linked to defective NEMO ubiquitination Genetic lessons learned from X-linked Mendelian susceptibility to mycobacterial diseases.Immune responses that adapt the intestinal mucosa to commensal intestinal bacteria.Default in plasma and intestinal IgA responses during acute infection by simian immunodeficiency virus.X-linked susceptibility to mycobacteria is caused by mutations in NEMO impairing CD40-dependent IL-12 production.Recruitment of A20 by the C-terminal domain of NEMO suppresses NF-κB activation and autoinflammatory disease.Immunoglobulin class-switch recombination deficiencies.Impaired priming and activation of the neutrophil NADPH oxidase in patients with IRAK4 or NEMO deficiency.The zinc finger domain of IKKγ (NEMO) protein in health and disease Memory B cells: effectors of long-lived immune responses.Unique properties of memory B cells of different isotypes.T cell-B cell interactions in primary immunodeficiencies.NF-κB function in B lymphocytes.DNA damage-dependent NF-κB activation: NEMO turns nuclear signaling inside out.Pathologic Findings in NEMO Deficiency: A Surgical and Autopsy Survey.A novel gain-of-function IKBA mutation underlies ectodermal dysplasia with immunodeficiency and polyendocrinopathy.B cell subsets in healthy children: reference values for evaluation of B cell maturation process in peripheral blood.Decreased expression in nuclear factor-κB essential modulator due to a novel splice-site mutation causes X-linked ectodermal dysplasia with immunodeficiency.

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Specific NEMO mutations impair CD40-mediated c-Rel activation and B cell terminal differentiation.

http://www.wikidata.org/entity/Q37628194

description

article científic

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article scientifique

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bilimsel makale

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scientific article published on December 2004

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vedecký článok

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Specific NEMO mutations impair ...... cell terminal differentiation.

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Specific NEMO mutations impair ...... cell terminal differentiation.

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Specific NEMO mutations impair ...... cell terminal differentiation.

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Specific NEMO mutations impair ...... cell terminal differentiation.

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Specific NEMO mutations impair ...... cell terminal differentiation.

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Specific NEMO mutations impair ...... cell terminal differentiation.

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Journal of Clinical Investigation

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Specific NEMO mutations impair ...... cell terminal differentiation.

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Ashish Jain

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Chi A Ma

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Eduardo Lopez-Granados

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Gary Means

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Jonathan M J Derry

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Jordan S Orange

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Shuying Liu

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Steven Holland

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William Brady

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P2860

Physical interaction of the bHLH LYL1 protein and NF-kappaB1 p105

Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)

Sequential modification of NEMO/IKKgamma by SUMO-1 and ubiquitin mediates NF-kappaB activation by genotoxic stress

Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO

A novel X-linked disorder of immune deficiency and hypohidrotic ectodermal dysplasia is allelic to incontinentia pigmenti and due to mutations in IKK-gamma (NEMO)

Transcriptional analysis of the B cell germinal center reaction

Helix-loop-helix proteins LYL1 and E2a form heterodimeric complexes with distinctive DNA-binding properties in hematolymphoid cells

Genetic variants of NHEJ DNA ligase IV can affect the risk of developing multiple myeloma, a tumour characterised by aberrant class switch recombination

Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity

A role for NF-kappaB essential modifier/IkappaB kinase-gamma (NEMO/IKKgamma) ubiquitination in the activation of the IkappaB kinase complex by tumor necrosis factor-alpha

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1593-1602

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scholarly article

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10.1172/JCI21345

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11

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114

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2004-12-01T00:00:00Z

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15578091

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529497

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