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Genetic studies of body mass index yield new insights for obesity biologyGenome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levelsEffect of the stromelysin-1 promoter on efficacy of pravastatin in coronary atherosclerosis and restenosisGenomic structure of the human PLZF geneVariation in the SHC1 gene and longevity in humansLipoprotein particle profiles mark familial and sporadic human longevityDiscovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density ImputationGenome of The Netherlands population-specific imputations identify an ABCA6 variant associated with cholesterol levelsThe Genome of the Netherlands: design, and project goalsDesign, recruitment, logistics, and data management of the GEHA (Genetics of Healthy Ageing) projectTranscriptional profiling of human familial longevity indicates a role for ASF1A and IL7RHuman longevity and variation in GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidant pathway genes: cross sectional and longitudinal studiesChromosome 4q25, microsomal transfer protein gene, and human longevity: novel data and a meta-analysis of association studies.Short telomere length is associated with impaired cognitive performance in European ancestry cohorts.Decreased levels of bisecting GlcNAc glycoforms of IgG are associated with human longevity.Leukocyte telomere length associates with prospective mortality independent of immune-related parameters and known genetic markers.Homocysteine and familial longevity: the Leiden Longevity StudyLow mitochondrial DNA content associates with familial longevity: the Leiden Longevity Study.Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age.Gene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF-1 signaling and telomere maintenance pathways.How to deal with the early GWAS data when imputing and combining different arrays is necessaryNovel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.Genome-wide association study (GWAS)-identified disease risk alleles do not compromise human longevity.Human longevity and 11p15.5: a study in 1321 centenariansA genome-wide linkage scan reveals CD53 as an important regulator of innate TNF-alpha levels.Aging as accelerated accumulation of somatic variants: whole-genome sequencing of centenarian and middle-aged monozygotic twin pairs.Genomics of human longevity.Defining the role of common variation in the genomic and biological architecture of adult human height.Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid functionLipid metabolism in long-lived families: the Leiden Longevity StudyMeta-analysis on blood transcriptomic studies identifies consistently coexpressed protein-protein interaction modules as robust markers of human agingNew genetic loci link adipose and insulin biology to body fat distribution.Association of adiponectin and leptin with relative telomere length in seven independent cohorts including 11,448 participants.Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited.C-reactive protein and glucose regulation in familial longevityMultiethnic genome-wide association study of cerebral white matter hyperintensities on MRIAssociation between the rs7903146 Polymorphism in the TCF7L2 Gene and Parameters Derived with Continuous Glucose Monitoring in Individuals without Diabetes.Shuttling between species for pathways of lifespan regulation: a central role for the vitellogenin gene family?Variation in the human TP53 gene affects old age survival and cancer mortality.
P50
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P50
description
hulumtues
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հետազոտող
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Marian Beekman
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Marian Beekman
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Marian Beekman
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Marian Beekman
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Marian Beekman
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Marian Beekman
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Marian Beekman
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Marian Beekman
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Marian Beekman
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Marian Beekman
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Marian Beekman
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Marian Beekman
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Marian Beekman
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Marian Beekman
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Marian Beekman
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Marian Beekman
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P106
P1960
GECQmPAAAAAJ
P21
P2798
P31
P496
0000-0003-0585-6206