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UHRF1 overexpression drives DNA hypomethylation and hepatocellular carcinoma

UHRF1 overexpression drives DNA hypomethylation and hepatocellular carcinoma

http://www.wikidata.org/entity/Q37632823

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Zebrafish: an important tool for liver disease research Identification of Chemical Inhibitors of β-Catenin-Driven Liver Tumorigenesis in Zebrafish DNA methylation, its mediators and genome integrity Zebrafish as a disease model for studying human hepatocellular carcinoma MBD4 interacts with and recruits USP7 to heterochromatic foci Activating transcription factor 6 is necessary and sufficient for alcoholic fatty liver disease in zebrafish Overexpression of UHRF1 gene correlates with the major clinicopathological parameters in urinary bladder cancer.Downregulation of UHRF1 increases tumor malignancy by activating the CXCR4/AKT-JNK/IL-6/Snail signaling axis in hepatocellular carcinoma cells.Zebrafish as a model to assess cancer heterogeneity, progression and relapse.Functional dissection of the role of UHRF1 in the regulation of retinoblastoma methylome.Upregulated UHRF1 promotes bladder cancer cell invasion by epigenetic silencing of KiSS1.DNA hypomethylation induces a DNA replication-associated cell cycle arrest to block hepatic outgrowth in uhrf1 mutant zebrafish embryos Epigenetic control of intestinal barrier function and inflammation in zebrafish.H3K9 methyltransferase G9a negatively regulates UHRF1 transcription during leukemia cell differentiation Establishment of a DNA methylation marker to evaluate cancer cell fraction in gastric cancer.AIP1 is a novel Agenet/Tudor domain protein from Arabidopsis that interacts with regulators of DNA replication, transcription and chromatin remodeling.An integrative pan-cancer-wide analysis of epigenetic enzymes reveals universal patterns of epigenomic deregulation in cancer Regulation of UHRF1 by microRNA-9 modulates colorectal cancer cell proliferation and apoptosis.Elevated expression of UHRF1 predicts unfavorable prognosis for patients with hepatocellular carcinoma.Targeted disruption of fibrinogen like protein-1 accelerates hepatocellular carcinoma development.A gene expression signature identifying transient DNMT1 depletion as a causal factor of cancer-germline gene activation in melanoma.UHRF1 promotes proliferation of gastric cancer via mediating tumor suppressor gene hypermethylation.High-fat diet intake from senescence inhibits the attenuation of cell functions and the degeneration of villi with aging in the small intestine, and inhibits the attenuation of lipid absorption ability in SAMP8 mice.E2F8 as a Novel Therapeutic Target for Lung Cancer A Tox21 Approach to Altered Epigenetic Landscapes: Assessing Epigenetic Toxicity Pathways Leading to Altered Gene Expression and Oncogenic Transformation In Vitro Development of a conditional liver tumor model by mifepristone-inducible Cre recombination to control oncogenic kras V12 expression in transgenic zebrafish.A cell cycle-dependent BRCA1-UHRF1 cascade regulates DNA double-strand break repair pathway choice UHRF1 overexpression is involved in cell proliferation and biochemical recurrence in prostate cancer after radical prostatectomy UHRF1 regulation of Dnmt1 is required for pre-gastrula zebrafish development.Radiation-induced changes in DNA methylation of repetitive elements in the mouse heart Negative regulation of DNMT3A de novo DNA methylation by frequently overexpressed UHRF family proteins as a mechanism for widespread DNA hypomethylation in cancer.Comparative Epigenomic Profiling of the DNA Methylome in Mouse and Zebrafish Uncovers High Interspecies Divergence Antiproliferation of berberine is mediated by epigenetic modification of constitutive androstane receptor (CAR) metabolic pathway in hepatoma cells.Multidimensional Proteomics Reveals a Role of UHRF2 in the Regulation of Epithelial-Mesenchymal Transition (EMT).Uhrf1 controls the self-renewal versus differentiation of hematopoietic stem cells by epigenetically regulating the cell-division modes.UHRF1 regulates global DNA hypomethylation and is associated with poor prognosis in esophageal squamous cell carcinoma.Zebrafish Discoveries in Cancer Epigenetics.Elevated UHRF1 expression contributes to poor prognosis by promoting cell proliferation and metastasis in hepatocellular carcinoma.CDDO-Me reveals USP7 as a novel target in ovarian cancer cells.miR-377 induces senescence in human skin fibroblasts by targeting DNA methyltransferase 1.

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UHRF1 overexpression drives DNA hypomethylation and hepatocellular carcinoma

http://www.wikidata.org/entity/Q37632823

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

@pt

bilimsel makale

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scientific article published on 30 January 2014

@en

vedecký článok

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vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

UHRF1 overexpression drives DNA hypomethylation and hepatocellular carcinoma

@en

UHRF1 overexpression drives DNA hypomethylation and hepatocellular carcinoma.

@nl

type

label

UHRF1 overexpression drives DNA hypomethylation and hepatocellular carcinoma

@en

UHRF1 overexpression drives DNA hypomethylation and hepatocellular carcinoma.

@nl

prefLabel

UHRF1 overexpression drives DNA hypomethylation and hepatocellular carcinoma

@en

UHRF1 overexpression drives DNA hypomethylation and hepatocellular carcinoma.

@nl

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J.CCR.2014.01.003

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UHRF1 overexpression drives DNA hypomethylation and hepatocellular carcinoma

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Anal Desai

http://www.w3.org/2001/XMLSchema#string

Anja Lachenmayer

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Chinweike Ukomadu

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Clara Alsinet

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Kate Revill

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Kensuke Kojima

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Kirsten C Sadler

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M Isabel Fiel

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Raksha Mudbhary

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Ravi Sachidanandam

http://www.w3.org/2001/XMLSchema#string

P2860

UHRF1 plays a role in maintaining DNA methylation in mammalian cells

Role of epigenetic aberrations in the development and progression of human hepatocellular carcinoma

The SRA domain of UHRF1 flips 5-methylcytosine out of the DNA helix

Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1

Recognition of hemi-methylated DNA by the SRA protein UHRF1 by a base-flipping mechanism

Sorafenib in advanced hepatocellular carcinoma

The SRA protein Np95 mediates epigenetic inheritance by recruiting Dnmt1 to methylated DNA

Usp7 and Uhrf1 control ubiquitination and stability of the maintenance DNA methyltransferase Dnmt1

Hepatocellular carcinoma

Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

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196-209

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scholarly article

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10.1016/J.CCR.2014.01.003

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2

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25

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Josep M. Llovet

Augusto Villanueva

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2014-01-30T00:00:00Z

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260023286

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24486181

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