KLF8 promotes human breast cancer cell invasion and metastasis by transcriptional activation of MMP9.
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Arginine methyltransferases as novel therapeutic targets for breast cancerHER2 and uPAR cooperativity contribute to metastatic phenotype of HER2-positive breast cancerThe endochondral bone protein CHM1 sustains an undifferentiated, invasive phenotype, promoting lung metastasis in Ewing sarcoma.Olfactomedin-1 activity identifies a cell invasion checkpoint during epithelial-mesenchymal transition in the chick embryonic heart.KLF8 knockdown suppresses proliferation and invasion in human osteosarcoma cells.Krüppel-like factor 8 (KLF8) is expressed in gliomas of different WHO grades and is essential for tumor cell proliferation.Nuclear factor I-C (NFIC) regulates dentin sialophosphoprotein (DSPP) and E-cadherin via control of Krüppel-like factor 4 (KLF4) during dentinogenesis.Generation of mice deficient in both KLF3/BKLF and KLF8 reveals a genetic interaction and a role for these factors in embryonic globin gene silencingUbiquitin-conjugating enzyme complex Uev1A-Ubc13 promotes breast cancer metastasis through nuclear factor-кB mediated matrix metalloproteinase-1 gene regulation.Sox2 suppresses the invasiveness of breast cancer cells via a mechanism that is dependent on Twist1 and the status of Sox2 transcription activity.MDM2 promotes invasion and metastasis in invasive ductal breast carcinoma by inducing matrix metalloproteinase-9.Identification of poly (ADP-ribose) polymerase-1 (PARP-1) as a novel Kruppel-like factor 8-interacting and -regulating proteinTestes-specific protease 50 promotes cell invasion and metastasis by increasing NF-kappaB-dependent matrix metalloproteinase-9 expression.PinX1 inhibits the invasion and metastasis of human breast cancer via suppressing NF-κB/MMP-9 signaling pathway.Protein arginine methyltransferase 7 promotes breast cancer cell invasion through the induction of MMP9 expressionFunctional genomics screening utilizing mutant mouse embryonic stem cells identifies novel radiation-response genes.Krüppel-like factor 8 contributes to hypoxia-induced MDR in gastric cancer cells.RNAi targeting CXCR4 inhibits tumor growth through inducing cell cycle arrest and apoptosis.Small hairpin RNA-mediated Krüppel-like factor 8 gene knockdown inhibits invasion of nasopharyngeal carcinoma.Plantamajoside, a potential anti-tumor herbal medicine inhibits breast cancer growth and pulmonary metastasis by decreasing the activity of matrix metalloproteinase-9 and -2.Orally bioavailable small-molecule inhibitor of transcription factor Stat3 regresses human breast and lung cancer xenografts.Krüppel-like factor 8 emerges as an important regulator of cancerIdentification of epidermal growth factor receptor and its inhibitory microRNA141 as novel targets of Krüppel-like factor 8 in breast cancerKLF8 promotes tumorigenesis, invasion and metastasis of colorectal cancer cells by transcriptional activation of FHL2.ERK2 phosphorylates Krüppel-like factor 8 protein at serine 48 to maintain its stability.Krüppel-like factor 8 overexpression is correlated with angiogenesis and poor prognosis in gastric cancer.Krüppel-like factor 8 promotes tumorigenic mammary stem cell induction by targeting miR-146a.Krüppel-like factor 8 activates the transcription of C-X-C cytokine receptor type 4 to promote breast cancer cell invasion, transendothelial migration and metastasis.Downregulated Krüppel-like factor 8 is involved in decreased trophoblast invasion under hypoxia-reoxygenation conditionsKLF5 activates microRNA 200 transcription to maintain epithelial characteristics and prevent induced epithelial-mesenchymal transition in epithelial cells.PPARγ maintains ERBB2-positive breast cancer stem cells.FGFR3 silencing by siRNA inhibits invasion of A549 cellsKLF8 and FAK cooperatively enrich the active MMP14 on the cell surface required for the metastatic progression of breast cancerCollagen triple helix repeat containing 1 (CTHRC1) acts via ERK-dependent induction of MMP9 to promote invasion of colorectal cancer cells.Transformation of human ovarian surface epithelial cells by Krüppel-like factor 8.Identification of epithelial stromal interaction 1 as a novel effector downstream of Krüppel-like factor 8 in breast cancer invasion and metastasisKrüppel-like factors in cancer progression: three fingers on the steering wheel.Role of Krüppel-like factors in cancer stem cells.Pancreatic cancer stem cells.Expression of Kruppel-like factor 8 and Ki67 in lung adenocarcinoma and prognosis.
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KLF8 promotes human breast cancer cell invasion and metastasis by transcriptional activation of MMP9.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 13 December 2010
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
KLF8 promotes human breast can ...... criptional activation of MMP9.
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KLF8 promotes human breast can ...... criptional activation of MMP9.
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type
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KLF8 promotes human breast can ...... criptional activation of MMP9.
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KLF8 promotes human breast can ...... criptional activation of MMP9.
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prefLabel
KLF8 promotes human breast can ...... criptional activation of MMP9.
@en
KLF8 promotes human breast can ...... criptional activation of MMP9.
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P2093
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KLF8 promotes human breast can ...... criptional activation of MMP9.
@en
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A M Urvalek
C M DiPersio
P J Feustel
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P2888
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10.1038/ONC.2010.563
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P577
2010-12-13T00:00:00Z