Systemic versus cartilage-specific expression of a type II collagen-specific T-cell epitope determines the level of tolerance and susceptibility to arthritis.
about
Interferon-gamma production in response to in vitro stimulation with collagen type II in rheumatoid arthritis is associated with HLA-DRB1(*)0401 and HLA-DQ8T cells that are naturally tolerant to cartilage-derived type II collagen are involved in the development of collagen-induced arthritisCollagen type II (CII)-specific antibodies induce arthritis in the absence of T or B cells but the arthritis progression is enhanced by CII-reactive T cellsJoint-specific and systemic autoreactivity in the development of inflammatory arthritis.Predominant selection of T cells specific for the glycosylated collagen type II epitope (263-270) in humanized transgenic mice and in rheumatoid arthritisTransgenic mouse models of rheumatoid arthritis.The genetic and immunopathological processes underlying collagen-induced arthritis.Role of glycopeptide-specific T cells in collagen-induced arthritis: an example how post-translational modification of proteins may be involved in autoimmune disease.Widespread expression of an autoantigen-GAD65 transgene does not tolerize non-obese diabetic mice and can exacerbate diseaseVaccination without autoantigen protects against collagen II-induced arthritis via immune deviation and regulatory T cellsEnhanced autoimmunity, arthritis, and encephalomyelitis in mice with a reduced oxidative burst due to a mutation in the Ncf1 gene.Ncf1 polymorphism reveals oxidative regulation of autoimmune chronic inflammation.Cystatin C influences the autoimmune but not inflammatory response to cartilage type II collagen leading to chronic arthritis development.A novel preclinical model for rheumatoid arthritis research.Citrullination of self-proteins and autoimmunity.Bystander suppression of murine collagen-induced arthritis by long-term nasal administration of a self type II collagen peptide.CTLA-4 expressed by FOXP3+ regulatory T cells prevents inflammatory tissue attack and not T-cell priming in arthritis.T cells specific for post-translational modifications escape intrathymic tolerance induction.
P2860
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P2860
Systemic versus cartilage-specific expression of a type II collagen-specific T-cell epitope determines the level of tolerance and susceptibility to arthritis.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on April 1996
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Systemic versus cartilage-spec ...... d susceptibility to arthritis.
@en
Systemic versus cartilage-spec ...... d susceptibility to arthritis.
@nl
type
label
Systemic versus cartilage-spec ...... d susceptibility to arthritis.
@en
Systemic versus cartilage-spec ...... d susceptibility to arthritis.
@nl
prefLabel
Systemic versus cartilage-spec ...... d susceptibility to arthritis.
@en
Systemic versus cartilage-spec ...... d susceptibility to arthritis.
@nl
P2093
P2860
P356
P1476
Systemic versus cartilage-spec ...... d susceptibility to arthritis.
@en
P2093
Burkhardt H
Holmdahl R
Malmström V
Mattsson R
Michaëlsson E
P2860
P304
P356
10.1073/PNAS.93.9.4480
P407
P577
1996-04-01T00:00:00Z