Widespread expression of an autoantigen-GAD65 transgene does not tolerize non-obese diabetic mice and can exacerbate disease
about
Regulation of GAD65 expression by SMAR1 and p53 upon Streptozotocin treatmentGlutamic acid decarboxylase-derived epitopes with specific domains expand CD4(+)CD25(+) regulatory T cells.Transgenes and knockout mutations in animal models of type 1 diabetes and multiple sclerosis.Restricted islet-cell reactive T cell repertoire of early pancreatic islet infiltrates in NOD mice.Prevention of type I diabetes transfer by glutamic acid decarboxylase 65 peptide 206-220-specific T cellsTransgenic models of autoimmune disease.Antigen-specific therapeutic approaches in Type 1 diabetesEvidence for a primary islet autoantigen (preproinsulin 1) for insulitis and diabetes in the nonobese diabetic mouse.Normal incidence of diabetes in NOD mice tolerant to glutamic acid decarboxylase.CD4(+) T cells from glutamic acid decarboxylase (GAD)65-specific T cell receptor transgenic mice are not diabetogenic and can delay diabetes transferAutoreactive human T-cell receptor initiates insulitis and impaired glucose tolerance in HLA DR4 transgenic mice.Transgenically induced GAD tolerance curtails the development of early beta-cell autoreactivities but causes the subsequent development of supernormal autoreactivities to other beta-cell antigens.AIRE-Deficient Patients Harbor Unique High-Affinity Disease-Ameliorating AutoantibodiesAre T-cell responses to GAD65 influential in type 1 diabetes?Insulin: a critical autoantigen and potential therapeutic agent in Type 1 diabetes.
P2860
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P2860
Widespread expression of an autoantigen-GAD65 transgene does not tolerize non-obese diabetic mice and can exacerbate disease
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
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1998年學術文章
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name
Widespread expression of an au ...... ice and can exacerbate disease
@ast
Widespread expression of an au ...... ice and can exacerbate disease
@en
type
label
Widespread expression of an au ...... ice and can exacerbate disease
@ast
Widespread expression of an au ...... ice and can exacerbate disease
@en
prefLabel
Widespread expression of an au ...... ice and can exacerbate disease
@ast
Widespread expression of an au ...... ice and can exacerbate disease
@en
P2093
P2860
P356
P1476
Widespread expression of an au ...... ice and can exacerbate disease
@en
P2093
P2860
P304
10055-10060
P356
10.1073/PNAS.95.17.10055
P407
P577
1998-08-01T00:00:00Z