RecQ helicases: multiple structures for multiple functions?
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The RecQ DNA helicases in DNA repairSF1 and SF2 helicases: family mattersRecQ helicase translocates along single-stranded DNA with a moderate processivity and tight mechanochemical couplingYeast Pif1 accelerates annealing of complementary DNA strands.Mobility in the structure of E.coli recQ helicase upon substrate binding as seen from molecular dynamics simulations.A helical bundle in the N-terminal domain of the BLM helicase mediates dimer and potentially hexamer formation.RecQ-core of BLM unfolds telomeric G-quadruplex in the absence of ATPThe dissolution of double Holliday junctions.Positive supercoiling in thermophiles and mesophiles: of the good and evil.Human RecQL4 helicase plays critical roles in prostate carcinogenesis.TOPBP1 recruits TOP2A to ultra-fine anaphase bridges to aid in their resolution.Unwinding forward and sliding back: an intermittent unwinding mode of the BLM helicase.The HRDC domain of E. coli RecQ helicase controls single-stranded DNA translocation and double-stranded DNA unwinding rates without affecting mechanoenzymatic coupling.Human RecQ helicases in DNA repair, recombination, and replication.Recombination events among virulence genes in malaria parasites are associated with G-quadruplex-forming DNA motifs.Multimeric BLM is dissociated upon ATP hydrolysis and functions as monomers in resolving DNA structuresEnhancement of human DNA polymerase η activity and fidelity is dependent upon a bipartite interaction with the Werner syndrome proteinA Comparative Study of G-Quadruplex Unfolding and DNA Reeling Activities of Human RECQ5 HelicaseThe BLM dissolvasome in DNA replication and repair.Visualization of human Bloom's syndrome helicase molecules bound to homologous recombination intermediates.Serines 440 and 467 in the Werner syndrome protein are phosphorylated by DNA-PK and affects its dynamics in response to DNA double strand breaksShuttling along DNA and directed processing of D-loops by RecQ helicase support quality control of homologous recombination.RecQ helicases; at the crossroad of genome replication, repair, and recombination.Structural studies of DNA end detection and resection in homologous recombination.Werner helicase wings DNA binding.A prominent β-hairpin structure in the winged-helix domain of RECQ1 is required for DNA unwinding and oligomer formation.The archaeal topoisomerase reverse gyrase is a helix-destabilizing protein that unwinds four-way DNA junctions.Site-directed mutants of human RECQ1 reveal functional importance of the zinc binding domainFork sensing and strand switching control antagonistic activities of RecQ helicases.On BLM helicase in recombination-mediated telomere maintenance.RAD5A, RECQ4A, and MUS81 have specific functions in homologous recombination and define different pathways of DNA repair in Arabidopsis thaliana.
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RecQ helicases: multiple structures for multiple functions?
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 18 March 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
RecQ helicases: multiple structures for multiple functions?
@en
RecQ helicases: multiple structures for multiple functions?
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type
label
RecQ helicases: multiple structures for multiple functions?
@en
RecQ helicases: multiple structures for multiple functions?
@nl
prefLabel
RecQ helicases: multiple structures for multiple functions?
@en
RecQ helicases: multiple structures for multiple functions?
@nl
P2860
P356
P1476
RecQ helicases: multiple structures for multiple functions?
@en
P2093
Alessandro Vindigni
Ian D Hickson
P2860
P304
P356
10.2976/1.3079540
P577
2009-03-18T00:00:00Z