Structures of nitric oxide synthase isoforms complexed with the inhibitor AR-R17477 suggest a rational basis for specificity and inhibitor design.
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Structure of human brain fructose 1,6-(bis)phosphate aldolase: linking isozyme structure with functionStructure-Based Design and Synthesis of N ω -Nitro- l -Arginine-Containing Peptidomimetics as Selective Inhibitors of Neuronal Nitric Oxide Synthase. Displacement of the Heme Structural WaterPeripheral but crucial: A hydrophobic pocket (Tyr706, Leu337, and Met336) for potent and selective inhibition of neuronal nitric oxide synthaseSimplified 2-Aminoquinoline-Based Scaffold for Potent and Selective Neuronal Nitric Oxide Synthase InhibitionThe anti-cancer agent SU4312 unexpectedly protects against MPP(+) -induced neurotoxicity via selective and direct inhibition of neuronal NOSHotSpot Wizard: a web server for identification of hot spots in protein engineering.Role of an isoform-specific substrate access channel residue in CO ligand accessibilities of neuronal and inducible nitric oxide synthase isoforms.Development of nitric oxide synthase inhibitors for neurodegeneration and neuropathic pain.Mechanism of Nitric Oxide Synthase Regulation: Electron Transfer and Interdomain Interactions.Novel 2,4-disubstituted pyrimidines as potent, selective, and cell-permeable inhibitors of neuronal nitric oxide synthase2-Aminopyridines with a Truncated Side Chain To Improve Human Neuronal Nitric Oxide Synthase Inhibitory Potency and SelectivityPhenyl Ether- and Aniline-Containing 2-Aminoquinolines as Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase.Target- and mechanism-based therapeutics for neurodegenerative diseases: strength in numbersMechanism of inducible nitric-oxide synthase dimerization inhibition by novel pyrimidine imidazoles.A cellular model for screening neuronal nitric oxide synthase inhibitorsDissecting regulation mechanism of the FMN to heme interdomain electron transfer in nitric oxide synthases.L337H mutant of rat neuronal nitric oxide synthase resembles human neuronal nitric oxide synthase toward inhibitors.Recent advances toward improving the bioavailability of neuronal nitric oxide synthase inhibitors.Nitric oxide synthase and structure-based inhibitor design.Nitric-oxide synthase output state. Design and properties of nitric-oxide synthase oxygenase/FMN domain constructs.Hydrophilic, Potent, and Selective 7-Substituted 2-Aminoquinolines as Improved Human Neuronal Nitric Oxide Synthase Inhibitors.Nitrile in the Hole: Discovery of a Small Auxiliary Pocket in Neuronal Nitric Oxide Synthase Leading to the Development of Potent and Selective 2-Aminoquinoline Inhibitors.A New Danshensu Derivative Protects Against 6-Hydroxydopamine-Induced Neurotoxicity In Vitro and In Vivo.Inhibition of i-NOS but not n-NOS protects rat primary cell cultures against MPP(+)-induced neuronal toxicity.
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P2860
Structures of nitric oxide synthase isoforms complexed with the inhibitor AR-R17477 suggest a rational basis for specificity and inhibitor design.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 07 April 2004
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Structures of nitric oxide syn ...... cificity and inhibitor design.
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Structures of nitric oxide syn ...... cificity and inhibitor design.
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type
label
Structures of nitric oxide syn ...... cificity and inhibitor design.
@en
Structures of nitric oxide syn ...... cificity and inhibitor design.
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prefLabel
Structures of nitric oxide syn ...... cificity and inhibitor design.
@en
Structures of nitric oxide syn ...... cificity and inhibitor design.
@nl
P2093
P2860
P356
P1476
Structures of nitric oxide syn ...... cificity and inhibitor design.
@en
P2093
Dipak K Ghosh
Roman Fedorov
Ryan Vasan
P2860
P304
P356
10.1073/PNAS.0306588101
P407
P577
2004-04-07T00:00:00Z