Protein kinase Calpha: disease regulator and therapeutic target. - Wikidata - wikimedia - TriplyDB

Protein kinase Calpha: disease regulator and therapeutic target.

Protein kinase Calpha: disease regulator and therapeutic target.

http://www.wikidata.org/entity/Q37647208

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PKC alpha regulates Sendai virus-mediated interferon induction through HDAC6 and β-catenin Tight junctions in human pancreatic duct epithelial cells mTOR signaling in tumorigenesis PKCγ participates in food entrainment by regulating BMAL1 Protein kinase Cα promotes cell migration through a PDZ-dependent interaction with its novel substrate discs large homolog 1 (DLG1)Computational drug repositioning for peripheral arterial disease: prediction of anti-inflammatory and pro-angiogenic therapeutics.Clinical significance of the correlation between PLCE 1 and PRKCA in esophageal inflammation and esophageal carcinoma.MicroRNA-200b suppresses arsenic-transformed cell migration by targeting protein kinase Cα and Wnt5b-protein kinase Cα positive feedback loop and inhibiting Rac1 activation Interactions of protein kinase C-α C1A and C1B domains with membranes: a combined computational and experimental study.Protein kinase Cα (PKCα) regulates bone architecture and osteoblast activity.Phosphorylation of Cdc42 effector protein-4 (CEP4) by protein kinase C promotes motility of human breast cells MicroRNA-200b targets protein kinase Cα and suppresses triple-negative breast cancer metastasis A kinase inhibitor screen reveals protein kinase C-dependent endocytic recycling of ErbB2 in breast cancer cells.INTRACELLULAR SIGNALING BY BILE ACIDS.PKC activation by resveratrol derivatives with unsaturated aliphatic chain Clinicopathological correlation and prognostic significance of protein kinase cα overexpression in human gastric carcinoma.Protein kinase C-α signals P115RhoGEF phosphorylation and RhoA activation in TNF-α-induced mouse brain microvascular endothelial cell barrier dysfunction Protein phosphorylation detection using dual-mode field-effect devices and nanoplasmonic sensors.PKCα promotes the mesenchymal to amoeboid transition and increases cancer cell invasiveness.Protein kinase C regulation of 12-lipoxygenase-mediated human platelet activation.PKCα and ERβ Are Associated with Triple-Negative Breast Cancers in African American and Caucasian Patients.Bryostatin-1 vs. TPPB: dose-dependent APP processing and PKC-α, -δ, and -ε isoform activation in SH-SY5Y neuronal cells.Analysis of substrates of protein kinase C isoforms in human breast cells by the traceable kinase method.Protein kinase C mediates platelet secretion and thrombus formation through protein kinase D2 Iptakalim, a novel ATP-sensitive potassium channel opener, inhibits pulmonary arterial smooth muscle cell proliferation by downregulation of PKC-α.Protein kinase C, an elusive therapeutic target?Protein phosphatase 2A is regulated by protein kinase Cα (PKCα)-dependent phosphorylation of its targeting subunit B56α at Ser41.A novel approach to exploring potential interactions among single-nucleotide polymorphisms of inflammation genes in gliomagenesis: an exploratory case-only study.Platelet signaling-a primer.Targeting tight junctions during epithelial to mesenchymal transition in human pancreatic cancer.Peptidyl-prolyl isomerases: functionality and potential therapeutic targets in cardiovascular disease.Differential targeting of cPKC and nPKC decodes and regulates Ca²⁺ and lipid signalling.Specific miRNA and its target in neutrophils after traumatic injury.Suppression of A549 cell proliferation and metastasis by calycosin via inhibition of the PKC‑α/ERK1/2 pathway: An in vitro investigation.Interacting post-muscarinic receptor signaling pathways potentiate matrix metalloproteinase-1 expression and invasion of human colon cancer cells.Protein Kinase C-α is a Critical Protein for Antisense Oligonucleotide-mediated Silencing in Mammalian Cells Anticarcinogenic action of quercetin by downregulation of phosphatidylinositol 3-kinase (PI3K) and protein kinase C (PKC) via induction of p53 in hepatocellular carcinoma (HepG2) cell line.The role of protein kinase C-mediated phosphorylation of sarcomeric proteins in the heart-detrimental or beneficial?Protein kinase Cα inhibitor enhances the sensitivity of human pancreatic cancer HPAC cells to Clostridium perfringens enterotoxin via claudin-4.Protein kinase Cα suppresses the expression of STC1 in MDA-MB-231 breast cancer cells.

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Protein kinase Calpha: disease regulator and therapeutic target.

http://www.wikidata.org/entity/Q37647208

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 05 December 2009

@en

vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Protein kinase Calpha: disease regulator and therapeutic target.

@en

Protein kinase Calpha: disease regulator and therapeutic target.

@nl

type

label

Protein kinase Calpha: disease regulator and therapeutic target.

@en

Protein kinase Calpha: disease regulator and therapeutic target.

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prefLabel

Protein kinase Calpha: disease regulator and therapeutic target.

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Protein kinase Calpha: disease regulator and therapeutic target.

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J.TIPS.2009.10.006

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Trends in Pharmacological Sciences

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Protein kinase Calpha: disease regulator and therapeutic target

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Olga Konopatskaya

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Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported

P2860

Inhibition of protein kinase Calpha prevents endothelial cell migration and vascular tube formation in vitro and myocardial neovascularization in vivo

Direct demonstration of involvement of protein kinase Calpha in the Ca2+-induced platelet aggregation

Protease-activated receptor-1 activation of endothelial cells induces protein kinase Calpha-dependent phosphorylation of syntaxin 4 and Munc18c: role in signaling p-selectin expression

Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth

Identification of a functionally critical protein kinase C phosphorylation residue of cardiac troponin T

Clinical aspects of platelet inhibitors and thrombus formation

Ca(2+) signalling and PKCalpha activate increased endothelial permeability by disassembly of VE-cadherin junctions

PKCalpha regulates platelet granule secretion and thrombus formation in mice

PKC alpha regulates the hypertrophic growth of cardiomyocytes through extracellular signal-regulated kinase1/2 (ERK1/2)

PKC-alpha regulates cardiac contractility and propensity toward heart failure

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Alastair W Poole

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