DNA secondary structures and epigenetic determinants of cancer genome evolution.
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Getting Ready for the Dance: FANCJ Irons Out DNA WrinklesG-quadruplexes and their regulatory roles in biologyLinking genome to epigenomeCancer genome sequencing: understanding malignancy as a disease of the genome, its conformation, and its evolution.G-quadruplexes in pathogens: a common route to virulence control?Chromatin, DNA structure and alternative splicingSnaps and mends: DNA breaks and chromosomal translocationsThe G4 genomePatterns of somatically acquired amplifications and deletions in apparently normal tissues of ovarian cancer patientsEmergence of FGFR family gene fusions as therapeutic targets in a wide spectrum of solid tumoursEvolution of the cancer genomeDNA secondary structure at chromosomal fragile sites in human disease.Genetic Mutations and Epigenetic Modifications: Driving Cancer and Informing Precision Medicine.Genetics and epigenetics of the skin meet deep sequence.Association of G-quadruplex forming sequences with human mtDNA deletion breakpoints.What does physics have to do with cancer?Differential relationship of DNA replication timing to different forms of human mutation and variation.G-quadruplex recognition activities of E. Coli MutS.Three-dimensional genome architecture influences partner selection for chromosomal translocations in human disease.LRpath analysis reveals common pathways dysregulated via DNA methylation across cancer typesCharacterisation of the potential function of SVA retrotransposons to modulate gene expression patternsThe dilemma of choosing the ideal permutation strategy while estimating statistical significance of genome-wide enrichmentTandem repeats and G-rich sequences are enriched at human CNV breakpointsElevated levels of G-quadruplex formation in human stomach and liver cancer tissues.Guanine quadruplexes are formed by specific regions of human transposable elements.Translating cancer 'omics' to improved outcomes.Clonal expansion and linear genome evolution through breast cancer progression from pre-invasive stages to asynchronous metastasisPromoter G-quadruplex sequences are targets for base oxidation and strand cleavage during hypoxia-induced transcriptionA Role for the Fifth G-Track in G-Quadruplex Forming Oncogene Promoter Sequences during Oxidative Stress: Do These "Spare Tires" Have an Evolved Function?Cancer as a dysregulated epigenome allowing cellular growth advantage at the expense of the hostEvidence for the kinetic partitioning of polymerase activity on G-quadruplex DNA.Comparative analysis of somatic copy-number alterations across different human cancer types reveals two distinct classes of breakpoint hotspots.COSMOS: accurate detection of somatic structural variations through asymmetric comparison between tumor and normal samplesChromatin accessibility contributes to simultaneous mutations of cancer genes.Amplification of distant estrogen response elements deregulates target genes associated with tamoxifen resistance in breast cancer.Bioinformatic analysis reveals an evolutional selection for DNA:RNA hybrid G-quadruplex structures as putative transcription regulatory elements in warm-blooded animalsDNA replication timing and long-range DNA interactions predict mutational landscapes of cancer genomes.Evidence for a Functional Link between Chromosomal Breakpoints and Aberrant DNA Methylation in CancerEmerging trends in G-quadruplex biology--role in epigenetic and evolutionary events.Interplay between the cancer genome and epigenome.
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DNA secondary structures and epigenetic determinants of cancer genome evolution.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 03 July 2011
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
DNA secondary structures and epigenetic determinants of cancer genome evolution.
@en
DNA secondary structures and epigenetic determinants of cancer genome evolution.
@nl
type
label
DNA secondary structures and epigenetic determinants of cancer genome evolution.
@en
DNA secondary structures and epigenetic determinants of cancer genome evolution.
@nl
prefLabel
DNA secondary structures and epigenetic determinants of cancer genome evolution.
@en
DNA secondary structures and epigenetic determinants of cancer genome evolution.
@nl
P2860
P356
P1476
DNA secondary structures and epigenetic determinants of cancer genome evolution.
@en
P2093
Franziska Michor
P2860
P2888
P304
P356
10.1038/NSMB.2089
P577
2011-07-03T00:00:00Z
P5875
P6179
1008260432