Metabolic activation of the nucleoside analog 9-[( 2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine in human diploid fibroblasts infected with human cytomegalovirus.
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Human cytomegalovirus resistance to antiviral drugsA human cytomegalovirus mutant resistant to the nucleoside analog 9-([2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine (BW B759U) induces reduced levels of BW B759U triphosphate6-Methoxypurine arabinoside as a selective and potent inhibitor of varicella-zoster virusNonnucleoside pyrrolopyrimidines with a unique mechanism of action against human cytomegalovirusPhosphorylation of beta-D-ribosylbenzimidazoles is not required for activity against human cytomegalovirusActivity of 9-(1,3-dihydroxy-2-propoxymethyl)guanine compared with that of acyclovir against human, monkey, and rodent cytomegalovirusesAcyclic guanosine analogs as inhibitors of human cytomegalovirusPyrrolo[2,3-d]pyrimidine nucleosides as inhibitors of human cytomegalovirusAnti-herpesvirus activities and cytotoxicities of 2-thiopyrimidine nucleoside analogues in vitro2-Acetylpyridine 5-[(dimethylamino)thiocarbonyl]-thiocarbonohydrazone (1110U81) potently inhibits human cytomegalovirus replication and potentiates the antiviral effects of ganciclovirEffect of incorporation of cidofovir into DNA by human cytomegalovirus DNA polymerase on DNA elongationMetabolic activation of 9([2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine in human lymphoblastoid cell lines infected with Epstein-Barr virusAcyclovir is phosphorylated by the human cytomegalovirus UL97 protein.Identification of broad-spectrum antiviral compounds and assessment of the druggability of their target for efficacy against respiratory syncytial virus (RSV)Detection of cytomegalovirus drug resistance mutations by next-generation sequencing.Lobucavir is phosphorylated in human cytomegalovirus-infected and -uninfected cells and inhibits the viral DNA polymeraseResistance of herpesviruses to antiviral drugsMetabolism of ribavirin in respiratory syncytial virus-infected and uninfected cells.A point mutation in the human cytomegalovirus DNA polymerase gene confers resistance to ganciclovir and phosphonylmethoxyalkyl derivatives.Antiviral therapy: current concepts and practicesQuantification of cytomegalovirus DNA in peripheral blood leukocytes by a branched-DNA signal amplification assay.Human cytomegalovirus induces JC virus DNA replication in human fibroblasts.Pharmacologic basis for high-dose oral acyclovir prophylaxis of cytomegalovirus disease in renal allograft recipients.Identification of the lytic origin of DNA replication in human cytomegalovirus by a novel approach utilizing ganciclovir-induced chain termination.Sequence and transcription analysis of the human cytomegalovirus DNA polymerase gene.The genetic basis of human cytomegalovirus resistance and current trends in antiviral resistance analysis.Novel method based on "en passant" mutagenesis coupled with a gaussia luciferase reporter assay for studying the combined effects of human cytomegalovirus mutations.Engineering of a chimeric RB69 DNA polymerase sensitive to drugs targeting the cytomegalovirus enzyme.The search for new therapies for human cytomegalovirus infections.Management of multidrug-resistant viruses in the immunocompromised host.Therapeutic strategies for the prevention and treatment of cytomegalovirus infection.Clinical pharmacokinetics and pharmacodynamics of ganciclovir and valganciclovir in children with cytomegalovirus infection.Recombinant phenotyping of cytomegalovirus UL54 mutations that emerged during cell passages in the presence of either ganciclovir or foscarnet.The Role of Antiviral Prophylaxis for the Prevention of Epstein-Barr Virus-Associated Posttransplant Lymphoproliferative Disease in Solid Organ Transplant Recipients: A Systematic Review.Metabolism of cyclopropavir and ganciclovir in human cytomegalovirus-infected cells.Antiviral guanosine analogs as substrates for deoxyguanosine kinase: implications for chemotherapy.Metabolism in human cells of the D and L enantiomers of the carbocyclic analog of 2'-deoxyguanosine: substrate activity with deoxycytidine kinase, mitochondrial deoxyguanosine kinase, and 5'-nucleotidase.Human herpesvirus 8-encoded thymidine kinase and phosphotransferase homologues confer sensitivity to ganciclovirChemotherapy of herpesvirus infections.In vitro and in vivo activities of the novel anticytomegalovirus compound AIC246.
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P2860
Metabolic activation of the nucleoside analog 9-[( 2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine in human diploid fibroblasts infected with human cytomegalovirus.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on April 1985
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Metabolic activation of the nucleoside analog 9-[
@nl
Metabolic activation of the nu ...... ed with human cytomegalovirus.
@en
type
label
Metabolic activation of the nucleoside analog 9-[
@nl
Metabolic activation of the nu ...... ed with human cytomegalovirus.
@en
prefLabel
Metabolic activation of the nucleoside analog 9-[
@nl
Metabolic activation of the nu ...... ed with human cytomegalovirus.
@en
P2093
P2860
P356
P1476
Metabolic activation of the nu ...... ed with human cytomegalovirus.
@en
P2093
Sorrell JB
P2860
P304
P356
10.1073/PNAS.82.8.2473
P407
P577
1985-04-01T00:00:00Z