Regulation of Mus81-Eme1 Holliday junction resolvase in response to DNA damage.
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Hold your horSSEs: controlling structure-selective endonucleases MUS81 and Yen1/GEN1How SLX4 cuts through the mystery of HIV-1 Vpr-mediated cell cycle arrest.Genetic instability in budding and fission yeast-sources and mechanismsThe Mus81-Mms4 structure-selective endonuclease requires nicked DNA junctions to undergo conformational changes and bend its DNA substrates for cleavage.Enrichment of Cdk1-cyclins at DNA double-strand breaks stimulates Fun30 phosphorylation and DNA end resection.Dbf4-dependent kinase and the Rtt107 scaffold promote Mus81-Mms4 resolvase activation during mitosisThe Intra-S Checkpoint Responses to DNA Damage.Resolving branched DNA intermediates with structure-specific nucleases during replication in eukaryotes.Holliday junction resolution: regulation in space and time.DNA damage repair machinery and HIV escape from innate immune sensing.Quality control of homologous recombination.Replication fork reversal in eukaryotes: from dead end to dynamic response.An Overview of the Molecular Mechanisms of Recombinational DNA Repair.Dual control of Yen1 nuclease activity and cellular localization by Cdk and Cdc14 prevents genome instability.Control of Mus81 nuclease during the cell cycle.Progression of pathology in PINK1-deficient mouse brain from splicing via ubiquitination, ER stress, and mitophagy changes to neuroinflammation.Temporal regulation of the Mus81-Mms4 endonuclease ensures cell survival under conditions of DNA damage.Checkpoints are blind to replication restart and recombination intermediates that result in gross chromosomal rearrangements.Lingering single-strand breaks trigger Rad51-independent homology-directed repair of collapsed replication forks in the polynucleotide kinase/phosphatase mutant of fission yeast.Essential domains of Schizosaccharomyces pombe Rad8 required for DNA damage responseThe nucleolytic resolution of recombination intermediates in yeast mitotic cells.Phosphorylation by CK2 regulates MUS81/EME1 in mitosis and after replication stress.
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Regulation of Mus81-Eme1 Holliday junction resolvase in response to DNA damage.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 14 April 2013
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vedecký článok
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Regulation of Mus81-Eme1 Holliday junction resolvase in response to DNA damage.
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Regulation of Mus81-Eme1 Holliday junction resolvase in response to DNA damage.
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Regulation of Mus81-Eme1 Holliday junction resolvase in response to DNA damage.
@en
Regulation of Mus81-Eme1 Holliday junction resolvase in response to DNA damage.
@nl
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Regulation of Mus81-Eme1 Holliday junction resolvase in response to DNA damage.
@en
Regulation of Mus81-Eme1 Holliday junction resolvase in response to DNA damage.
@nl
P2093
P2860
P356
P1476
Regulation of Mus81-Eme1 Holliday junction resolvase in response to DNA damage.
@en
P2093
Arato Takedachi
Bertrand Llorente
James A Wohlschlegel
John R Yates
Paul Russell
Paul Shanahan
Pierre-Henri L Gaillard
Pierre-Marie Dehé
Sarah Scaglione
Stéphane Coulon
P2860
P2888
P304
P356
10.1038/NSMB.2550
P577
2013-04-14T00:00:00Z
P6179
1031762564