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Transcriptional switches: chemical approaches to gene regulation

Transcriptional switches: chemical approaches to gene regulation

http://www.wikidata.org/entity/Q37690520

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Activation of LDL receptor expression by small RNAs complementary to a noncoding transcript that overlaps the LDLR promoter Features of protein-protein interactions that translate into potent inhibitors: topology, surface area and affinity Polyamide-scorpion cyclam lexitropsins selectively bind AT-rich DNA independently of the nature of the coordinated metal The role of HTS in drug discovery at the University of Michigan.In vivo modulation of hypoxia-inducible signaling by topographical helix mimetics.Epidithiodiketopiperazines (ETPs) exhibit in vitro antiangiogenic and in vivo antitumor activity by disrupting the HIF-1α/p300 complex in a preclinical model of prostate cancer.Programmable genetic switches to control transcriptional machinery of pluripotency.Transcriptional/epigenetic regulator CBP/p300 in tumorigenesis: structural and functional versatility in target recognition.Prepaying the entropic cost for allosteric regulation in KIX Mini review: protein-protein interactions in transcription: a fertile ground for helix mimetics.Transient-state kinetic analysis of transcriptional activator·DNA complexes interacting with a key coactivator HTLV-1 HBZ protein deregulates interactions between cellular factors and the KIX domain of p300/CBP.Sekikaic acid and lobaric acid target a dynamic interface of the coactivator CBP/p300.Protein domain mimetics as in vivo modulators of hypoxia-inducible factor signaling.Bifunctional ligands allow deliberate extrinsic reprogramming of the glucocorticoid receptor.Caught in the act: covalent cross-linking captures activator-coactivator interactions in vivo.Novel Agents and Drug Targets to Meet the Challenges of Resistant Fungi.Synergistic enhancement of the potency and selectivity of small molecule transcriptional inhibitors Transcriptional tools: Small molecules for modulating CBP KIX-dependent transcriptional activators.Profiling the dynamic interfaces of fluorinated transcription complexes for ligand discovery and characterization.Sequence and expression analyses of KIX domain proteins suggest their importance in seed development and determination of seed size in rice, and genome stability in Arabidopsis.

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Transcriptional switches: chemical approaches to gene regulation

http://www.wikidata.org/entity/Q37690520

description

article científic

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article scientifique

@fr

articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 10 February 2010

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Transcriptional switches: chemical approaches to gene regulation

@en

Transcriptional switches: chemical approaches to gene regulation.

@nl

type

label

Transcriptional switches: chemical approaches to gene regulation

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Transcriptional switches: chemical approaches to gene regulation.

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prefLabel

Transcriptional switches: chemical approaches to gene regulation

@en

Transcriptional switches: chemical approaches to gene regulation.

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JBC.R109.075044

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Journal of Biological Chemistry

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Transcriptional switches: chemical approaches to gene regulation

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Anna K Mapp

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Lori W Lee

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P2860

An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis

Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha

Transcriptional regulation of the mdm2 oncogene by p53 requires TRRAP acetyltransferase complexes

External control of Her2 expression and cancer cell growth by targeting a Ras-linked coactivator

Mapping the interactions of the p53 transactivation domain with the KIX domain of CBP

Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapy

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

A surface on the androgen receptor that allosterically regulates coactivator binding

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11033-11038

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scholarly article

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10.1074/JBC.R109.075044

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15

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285

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2010-02-10T00:00:00Z

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20147748

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2856975

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