Calpains: attractive targets for the development of synthetic inhibitors.
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Cysteine proteases as therapeutic targets: does selectivity matter? A systematic review of calpain and cathepsin inhibitorsMacrocyclic protease inhibitors with reduced peptide characterSelenoprotein K is a novel target of m-calpain, and cleavage is regulated by Toll-like receptor-induced calpastatin in macrophagesUnderstanding the interaction determinants of CAPN1 inhibition by CAST4 from bovines using molecular modeling techniques.Homology modeling study of bovine μ-calpain inhibitor-binding domains.Synaptic therapy in Alzheimer's disease: a CREB-centric approach.Mechanism of action of thalassospiramides, a new class of calpain inhibitorsCrystal structure of N-{N-[N-acetyl-(S)-leuc-yl]-(S)-leuc-yl}norleucinal (ALLN), an inhibitor of proteasome.Tear me down: role of calpain in the development of cardiac ventricular hypertrophy.In silico affinity profiling of neuroactive polyphenols for post-traumatic calpain inactivation: a molecular docking and atomistic simulation sensitivity analysis.Development of α-helical calpain probes by mimicking a natural protein-protein interaction.Calpains mediate axonal cytoskeleton disintegration during Wallerian degeneration.Calpastatin prevents NF-κB-mediated hyperactivation of macrophages and attenuates colitis.Role of calpains in the injury-induced dysfunction and degeneration of the mammalian axon.Thioamide-based fluorescent protease sensorsCalpain inhibitors: a survey of compounds reported in the patent and scientific literature.High molecular weight calmodulin-binding protein: 20 years onwards-a potential therapeutic calpain inhibitor.Structure-function relationships in calpains.Calpain-1 inhibitors for selective treatment of rheumatoid arthritis: what is the future?An updated patent review of calpain inhibitors (2012 - 2014).Design, synthesis, and optimization of novel epoxide incorporating peptidomimetics as selective calpain inhibitors.A template-based approach to inhibitors of calpain 2, 20S proteasome, and HIV-1 protease.Inhibitors of polyhydroxyalkanoate (PHA) synthases: synthesis, molecular docking, and implications.The Toxic Effect of ALLN on Primary Rat Retinal Neurons.Novel Selective Calpain 1 Inhibitors as Potential Therapeutics in Alzheimer's Disease.Conformationally restricted calpain inhibitors.Synthesis and extended activity of triazole-containing macrocyclic protease inhibitors.Attenuation of Blood-Brain Barrier Breakdown and Hyperpermeability by Calpain Inhibition.Calpastatin, an endogenous calpain-inhibitor protein, regulates the cleavage of the Cdk5 activator p35 to p25.
P2860
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P2860
Calpains: attractive targets for the development of synthetic inhibitors.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on January 2010
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Calpains: attractive targets for the development of synthetic inhibitors.
@en
Calpains: attractive targets for the development of synthetic inhibitors.
@nl
type
label
Calpains: attractive targets for the development of synthetic inhibitors.
@en
Calpains: attractive targets for the development of synthetic inhibitors.
@nl
prefLabel
Calpains: attractive targets for the development of synthetic inhibitors.
@en
Calpains: attractive targets for the development of synthetic inhibitors.
@nl
P2093
P1476
Calpains: attractive targets for the development of synthetic inhibitors.
@en
P2093
Andrew D Abell
Krystle C H Chua
Markus Pietsch
P304
P356
10.2174/156802610790725489
P577
2010-01-01T00:00:00Z