Calpastatin, an endogenous calpain-inhibitor protein, regulates the cleavage of the Cdk5 activator p35 to p25.
about
Cdk5 activity in the brain - multiple paths of regulation.Specific calpain inhibition by calpastatin prevents tauopathy and neurodegeneration and restores normal lifespan in tau P301L miceOverexpression of the calpain-specific inhibitor calpastatin reduces human alpha-Synuclein processing, aggregation and synaptic impairment in [A30P]αSyn transgenic mice.Calpain-2 compensation promotes angiotensin II-induced ascending and abdominal aortic aneurysms in calpain-1 deficient miceCalpain inhibition attenuates angiotensin II-induced abdominal aortic aneurysms and atherosclerosis in low-density lipoprotein receptor-deficient mice.Targeting Caspase-12 to Preserve Vision in Mice With Inherited Retinal Degeneration.Psychological stress and aging: role of glucocorticoids (GCs)Erythropoietin Modulates Cerebral and Serum Degradation Products from Excess Calpain Activation following Prenatal Hypoxia-Ischemia.Leukocyte Calpain Deficiency Reduces Angiotensin II-Induced Inflammation and Atherosclerosis But Not Abdominal Aortic Aneurysms in Mice.Brain injury-induced proteolysis is reduced in a novel calpastatin-overexpressing transgenic mouse.High molecular weight calmodulin-binding protein: 20 years onwards-a potential therapeutic calpain inhibitor.Two Degradation Pathways of the p35 Cdk5 (Cyclin-dependent Kinase) Activation Subunit, Dependent and Independent of UbiquitinationHypoxia-triggered m-calpain activation evokes endoplasmic reticulum stress and neuropathogenesis in a transgenic mouse model of Alzheimer's disease.Cdk5 links with DNA damage response and cancer.Calpastatin upregulation in Mycoplasma hyorhinis-infected cells is promoted by the mycoplasma lipoproteins via the NF-κB pathway.Calpain Inhibition Attenuates Adipose Tissue Inflammation and Fibrosis in Diet-induced Obese Mice.A role for calpain-dependent cleavage of TDP-43 in amyotrophic lateral sclerosis pathology.Trichostatin A epigenetically increases calpastatin expression and inhibits calpain activity and calcium-induced SH-SY5Y neuronal cell toxicity.
P2860
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P2860
Calpastatin, an endogenous calpain-inhibitor protein, regulates the cleavage of the Cdk5 activator p35 to p25.
description
2011 nî lūn-bûn
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2011年の論文
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2011年学术文章
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2011年学术文章
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2011年学术文章
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2011年学术文章
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2011年学术文章
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2011年学术文章
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2011年學術文章
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name
Calpastatin, an endogenous cal ...... the Cdk5 activator p35 to p25.
@en
Calpastatin, an endogenous cal ...... the Cdk5 activator p35 to p25.
@nl
type
label
Calpastatin, an endogenous cal ...... the Cdk5 activator p35 to p25.
@en
Calpastatin, an endogenous cal ...... the Cdk5 activator p35 to p25.
@nl
prefLabel
Calpastatin, an endogenous cal ...... the Cdk5 activator p35 to p25.
@en
Calpastatin, an endogenous cal ...... the Cdk5 activator p35 to p25.
@nl
P2093
P2860
P1476
Calpastatin, an endogenous cal ...... the Cdk5 activator p35 to p25.
@en
P2093
Akiko Asada
Hiroyuki Kawahara
Jiro Takano
Nobuhisa Iwata
Seiji Minegishi
Shin-ichi Hisanaga
Takaomi C Saido
Taro Saito
P2860
P304
P356
10.1111/J.1471-4159.2011.07222.X
P407
P577
2011-03-15T00:00:00Z