Regulation of virus-specific CD4+ T cell function by multiple costimulatory receptors during chronic HIV infection.
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Role of PD-1 in HIV pathogenesis and as target for therapyRole of Tim-3 in hepatitis B virus infection: An overviewMolecular and cellular insights into T cell exhaustionInnate and Adaptive Immune Regulation During Chronic Viral InfectionsT-cell exhaustion in chronic hepatitis B infection: current knowledge and clinical significanceEngineering T Cells to Functionally Cure HIV-1 InfectionTim-3 directly enhances CD8 T cell responses to acute Listeria monocytogenes infectionDNA/MVA Vaccination of HIV-1 Infected Participants with Viral Suppression on Antiretroviral Therapy, followed by Treatment Interruption: Elicitation of Immune Responses without Control of Re-Emergent VirusProspects for treatment of latent HIV.Tobacco smoking increases immune activation and impairs T-cell function in HIV infected patients on antiretrovirals: a cross-sectional pilot studyRegulation of T cell responses by the receptor molecule Tim-3.Inhibitory phenotype of HBV-specific CD4+ T-cells is characterized by high PD-1 expression but absent coregulation of multiple inhibitory moleculesInhibitory receptors are expressed by Trypanosoma cruzi-specific effector T cells and in hearts of subjects with chronic Chagas diseaseAnimal models for viral infection and cell exhaustion.Role of PD-1 co-inhibitory pathway in HIV infection and potential therapeutic optionsDistinctive features of CD4+ T cell dysfunction in chronic viral infections.Regulatory T cells in HIV immunotherapyElevated expression of LAG-3, but not PD-1, is associated with impaired iNKT cytokine production during chronic HIV-1 infection and treatment.Responsiveness of HIV-specific CD4 T cells to PD-1 blockadeLymphocytic alveolitis is associated with the accumulation of functionally impaired HIV-specific T cells in the lung of antiretroviral therapy-naive subjectsPD-1+Tim-3+ CD8+ T Lymphocytes Display Varied Degrees of Functional Exhaustion in Patients with Regionally Metastatic Differentiated Thyroid CancerGenetic absence of PD-1 promotes accumulation of terminally differentiated exhausted CD8+ T cellsPositive and negative regulation of cellular immune responses in physiologic conditions and diseasesCD4+ T Cells Expressing PD-1, TIGIT and LAG-3 Contribute to HIV Persistence during ART.p38 Mitogen-activated protein kinase/signal transducer and activator of transcription-3 pathway signaling regulates expression of inhibitory molecules in T cells activated by HIV-1-exposed dendritic cells.CD4 T cell responses in latent and chronic viral infections.Impaired function of CTLA-4 in the lungs of patients with chronic beryllium disease contributes to persistent inflammation.In vivo blockade of the programmed cell death-1 pathway using soluble recombinant PD-1-Fc enhances CD4+ and CD8+ T cell responses but has limited clinical benefit.Differential impact of PD-1 and/or interleukin-10 blockade on HIV-1-specific CD4 T cell and antigen-presenting cell functions.HIV-specific CD4 T cells and immune control of viral replication.Too much of a good thing? Tim-3 and TCR signaling in T cell exhaustion.Preserving HIV-specific T cell responses: does timing of antiretroviral therapy help?Differential Expression of Immune Checkpoint Modulators on In Vitro Primed CD4(+) and CD8(+) T Cells.Multifarious immunotherapeutic approaches to cure HIV-1 infectionElevation of Tim-3 and PD-1 expression on T cells appears early in HIV infection, and differential Tim-3 and PD-1 expression patterns can be induced by common γ -chain cytokines.HIV controllers maintain a population of highly efficient Th1 effector cells in contrast to patients treated in the long term.PD-1 analysis on CD28(-) CD27(-) CD4 T cells allows stimulation-independent assessment of CMV viremic episodes in transplant recipients.PD-1/PDL1 and CD28/CD80 pathways modulate natural killer T cell function to inhibit hepatitis B virus replication.Diverse Intestinal Bacteria Contain Putative Zwitterionic Capsular Polysaccharides with Anti-inflammatory Properties.In vivo blockade of the PD-1 receptor suppresses HIV-1 viral loads and improves CD4+ T cell levels in humanized mice
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Regulation of virus-specific CD4+ T cell function by multiple costimulatory receptors during chronic HIV infection.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 23 July 2010
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Regulation of virus-specific C ...... during chronic HIV infection.
@en
Regulation of virus-specific C ...... during chronic HIV infection.
@nl
type
label
Regulation of virus-specific C ...... during chronic HIV infection.
@en
Regulation of virus-specific C ...... during chronic HIV infection.
@nl
prefLabel
Regulation of virus-specific C ...... during chronic HIV infection.
@en
Regulation of virus-specific C ...... during chronic HIV infection.
@nl
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P1476
Regulation of virus-specific C ...... during chronic HIV infection.
@en
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Andrew P Fontenot
Brent E Palmer
Cara C Wilson
Elizabeth A Kelly-McKnight
Lucy Golden-Mason
Michelle B D'Souza
Ramesh Akkina
Roland A Marcus
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P304
P356
10.4049/JIMMUNOL.1000156
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P577
2010-07-23T00:00:00Z