Inorganic phosphate blocks binding of pre-miRNA to Dicer-2 via its PAZ domain
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Production of small RNAs by mammalian DicerRNA Binding Proteins in the miRNA PathwaySensing viral RNAs by Dicer/RIG-I like ATPases across speciesMolecular mechanisms of Dicer: endonuclease and enzymatic activity.Common miR-590 Variant rs6971711 Present Only in African Americans Reduces miR-590 BiogenesisPhosphate-binding pocket in Dicer-2 PAZ domain for high-fidelity siRNA production.A universal small molecule, inorganic phosphate, restricts the substrate specificity of Dicer-2 in small RNA biogenesisGenomic alterations as mediators of miRNA dysregulation in ovarian cancer.Drosophila dicer-2 cleavage is mediated by helicase- and dsRNA termini-dependent states that are modulated by Loquacious-PD.Plant dicer-like proteins: double-stranded RNA-cleaving enzymes for small RNA biogenesis.Overexpression and purification of Dicer and accessory proteins for biochemical and structural studies.The C-terminal dsRNA-binding domain of Drosophila Dicer-2 is crucial for efficient and high-fidelity production of siRNA and loading of siRNA to Argonaute2.Kinetic Analysis of Small Silencing RNA Production by Human and Drosophila Dicer Enzymes In Vitro.Rewired RNAi-mediated genome surveillance in house dust mites.Dicer partner protein tunes the length of miRNAs using base-mismatch in the pre-miRNA stem.Post-Translational Regulation of the Dicing Activities of Arabidopsis DICER-LIKE 3 and 4 by Inorganic Phosphate and the Redox State.Loquacious-PD removes phosphate inhibition of Dicer-2 processing of hairpin RNAs into siRNAs.
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Inorganic phosphate blocks binding of pre-miRNA to Dicer-2 via its PAZ domain
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 31 January 2014
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Inorganic phosphate blocks binding of pre-miRNA to Dicer-2 via its PAZ domain
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Inorganic phosphate blocks binding of pre-miRNA to Dicer-2 via its PAZ domain.
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type
label
Inorganic phosphate blocks binding of pre-miRNA to Dicer-2 via its PAZ domain
@en
Inorganic phosphate blocks binding of pre-miRNA to Dicer-2 via its PAZ domain.
@nl
prefLabel
Inorganic phosphate blocks binding of pre-miRNA to Dicer-2 via its PAZ domain
@en
Inorganic phosphate blocks binding of pre-miRNA to Dicer-2 via its PAZ domain.
@nl
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P50
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Inorganic phosphate blocks binding of pre-miRNA to Dicer-2 via its PAZ domain
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Cansu Colpan
P2860
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10.1002/EMBJ.201387176
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2014-01-31T00:00:00Z