Differential ubiquitination and degradation of huntingtin fragments modulated by ubiquitin-protein ligase E3A.
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Subcellular Clearance and Accumulation of Huntington Disease Protein: A Mini-ReviewThe different roles of selective autophagic protein degradation in mammalian cellsTransgenic animal models for study of the pathogenesis of Huntington's disease and therapyThe struggle by Caenorhabditis elegans to maintain proteostasis during aging and diseaseAblation of huntingtin in adult neurons is nondeleterious but its depletion in young mice causes acute pancreatitis.Protein misfolding specifies recruitment to cytoplasmic inclusion bodiesA fine balance: Regulation of hippocampal Arc/Arg3.1 transcription, translation and degradation in a rat model of normal cognitive aging.Aged monkey brains reveal the role of ubiquitin-conjugating enzyme UBE2N in the synaptosomal accumulation of mutant huntingtin.Integration-independent Transgenic Huntington Disease Fragment Mouse Models Reveal Distinct Phenotypes and Life Span in Vivo.Polyglutamine Tract Expansion Increases S-Nitrosylation of Huntingtin and Ataxin-1.A new Caenorhabditis elegans model of human huntingtin 513 aggregation and toxicity in body wall musclesUbiquilin/Dsk2 promotes inclusion body formation and vacuole (lysosome)-mediated disposal of mutated huntingtinElevated Hapln2 Expression Contributes to Protein Aggregation and Neurodegeneration in an Animal Model of Parkinson's DiseaseDynamic droplets: the role of cytoplasmic inclusions in stress, function, and disease.Prion degradation pathways: Potential for therapeutic intervention.The Differential Profiling of Ubiquitin-Proteasome and Autophagy Systems in Different Tissues before the Onset of Huntington's Disease Models.The Ubiquitin Receptor ADRM1 Modulates HAP40-Induced Proteasome Activity.Detection of ubiquitinated huntingtin species in intracellular aggregates.Topoisomerase 1 inhibitor topotecan delays the disease progression in a mouse model of Huntington's disease.Deficiency of Ube3a in Huntington's disease mice brain increases aggregate load and accelerates disease pathology.Inhibition of PIP4Kγ ameliorates the pathological effects of mutant huntingtin protein.Azadiradione Restores Protein Quality Control and Ameliorates the Disease Pathogenesis in a Mouse Model of Huntington's Disease.Iron Loading Selectively Increases Hippocampal Levels of Ubiquitinated Proteins and Impairs Hippocampus-Dependent Memory.Ube3a deficiency inhibits amyloid plaque formation in APPswe/PS1δE9 mouse model of Alzheimer's disease.The absence of specific yeast heat-shock proteins leads to abnormal aggregation and compromised autophagic clearance of mutant Huntingtin proteins.Dynamic recruitment of ubiquitin to mutant huntingtin inclusion bodies.Preventing mutant huntingtin proteolysis and intermittent fasting promote autophagy in models of Huntington disease.A Huntingtin Knockin Pig Model Recapitulates Features of Selective Neurodegeneration in Huntington's Disease.Proteostasis in Huntington's disease: disease mechanisms and therapeutic opportunities.Transcriptional Dysregulation and Post-translational Modifications in Polyglutamine Diseases: From Pathogenesis to Potential Therapeutic Strategies.Active Site Gate Dynamics Modulate the Catalytic Activity of the Ubiquitination Enzyme E2-25K.Crosstalk Between Mammalian Autophagy and the Ubiquitin-Proteasome SystemDeubiquitinase Usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of Huntington's disease
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Differential ubiquitination and degradation of huntingtin fragments modulated by ubiquitin-protein ligase E3A.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 31 March 2014
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Differential ubiquitination an ...... ubiquitin-protein ligase E3A.
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Differential ubiquitination an ...... ubiquitin-protein ligase E3A.
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Differential ubiquitination an ...... ubiquitin-protein ligase E3A.
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Differential ubiquitination an ...... ubiquitin-protein ligase E3A.
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Differential ubiquitination an ...... ubiquitin-protein ligase E3A.
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Differential ubiquitination an ...... ubiquitin-protein ligase E3A.
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P2093
P2860
P356
P1476
Differential ubiquitination an ...... ubiquitin-protein ligase E3A.
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P2093
Chuan-En Wang
Kavita P Bhat
Xiao-Jiang Li
P2860
P304
P356
10.1073/PNAS.1402215111
P407
P577
2014-03-31T00:00:00Z