Ablation of huntingtin in adult neurons is nondeleterious but its depletion in young mice causes acute pancreatitis.
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Generation and Characterization of Knock-in Mouse Models Expressing Versions of Huntingtin with Either an N17 or a Combined PolyQ and Proline-Rich Region Deletion.Is Huntingtin Dispensable in the Adult Brain?N-terminal Huntingtin Knock-In Mice: Implications of Removing the N-terminal Region of Huntingtin for Therapy.Allele-Selective Suppression of Mutant Huntingtin in Primary Human Blood Cells.Peripheral huntingtin silencing does not ameliorate central signs of disease in the B6.HttQ111/+ mouse model of Huntington's diseasePreclinical Evaluation of a Lentiviral Vector for Huntingtin Silencing.Huntington Disease as a Neurodevelopmental Disorder and Early Signs of the Disease in Stem Cells.Cellular Analysis of Silencing the Huntington's Disease Gene Using AAV9 Mediated Delivery of Artificial Micro RNA into the Striatum of Q140/Q140 Mice.Elimination of huntingtin in the adult mouse leads to progressive behavioral deficits, bilateral thalamic calcification, and altered brain iron homeostasis.CRISPR/Cas9-mediated gene editing ameliorates neurotoxicity in mouse model of Huntington's disease.Gene suppression approaches to neurodegeneration.CRISPR/Cas9 Editing of the Mutant Huntingtin Allele In Vitro and In Vivo.Optimization of trans-Splicing for Huntington's Disease RNA Therapy.Postnatal and adult consequences of loss of huntingtin during development: Implications for Huntington's disease.Suppression of MAPK11 or HIPK3 reduces mutant Huntingtin levels in Huntington's disease models.Effect of early embryonic deletion of huntingtin from pyramidal neurons on the development and long-term survival of neurons in cerebral cortex and striatum.The prospects of CRISPR-based genome engineering in the treatment of neurodegenerative disorders.Translation of MicroRNA-Based Huntingtin-Lowering Therapies from Preclinical Studies to the Clinic.
P2860
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P2860
Ablation of huntingtin in adult neurons is nondeleterious but its depletion in young mice causes acute pancreatitis.
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2016 nî lūn-bûn
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2016 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2016 թվականի մարտին հրատարակված գիտական հոդված
@hy
2016年の論文
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2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
name
Ablation of huntingtin in adul ...... ice causes acute pancreatitis.
@ast
Ablation of huntingtin in adul ...... ice causes acute pancreatitis.
@en
type
label
Ablation of huntingtin in adul ...... ice causes acute pancreatitis.
@ast
Ablation of huntingtin in adul ...... ice causes acute pancreatitis.
@en
prefLabel
Ablation of huntingtin in adul ...... ice causes acute pancreatitis.
@ast
Ablation of huntingtin in adul ...... ice causes acute pancreatitis.
@en
P2093
P2860
P356
P1476
Ablation of huntingtin in adul ...... ice causes acute pancreatitis.
@en
P2093
Guohao Wang
Marta A Gaertig
Xiao-Jiang Li
Xudong Liu
P2860
P304
P356
10.1073/PNAS.1524575113
P407
P577
2016-03-07T00:00:00Z