Nutrient signaling in protein homeostasis: an increase in quantity at the expense of quality.
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Hepatoprotective role of Sestrin2 against chronic ER stressMice fed rapamycin have an increase in lifespan associated with major changes in the liver transcriptomePhosphorylated Ribosomal Protein S6 Is Required for Akt-Driven Hyperplasia and Malignant Transformation, but Not for Hypertrophy, Aneuploidy and Hyperfunction of Pancreatic β-CellsAltered proteome turnover and remodeling by short-term caloric restriction or rapamycin rejuvenate the aging heart.Mechanisms of In Vivo Ribosome Maintenance Change in Response to Nutrient Signals.MTO1 mediates tissue specificity of OXPHOS defects via tRNA modification and translation optimization, which can be bypassed by dietary intervention.Long-lived Snell dwarf mice display increased proteostatic mechanisms that are not dependent on decreased mTORC1 activity.Ubiquitination of newly synthesized proteins at the ribosome.Subacute calorie restriction and rapamycin discordantly alter mouse liver proteome homeostasis and reverse aging effectsReduced in vivo hepatic proteome replacement rates but not cell proliferation rates predict maximum lifespan extension in mice.The control of translational accuracy is a determinant of healthy ageing in yeast.Transcriptional regulation of the stress response by mTOR.Proteome complexity and the forces that drive proteome imbalance.Celastrol targets proteostasis and acts synergistically with a heat-shock protein 90 inhibitor to kill human glioblastoma cells.p(⁷⁰S⁶K¹) in the TORC1 pathway is essential for the differentiation of Th17 Cells, but not Th1, Th2, or Treg cells in mice.Mitochondrial-targeted catalase is good for the old mouse proteome, but not for the young: 'reverse' antagonistic pleiotropy?PRAS40 signaling in tumor.mTORC1 Coordinates Protein Synthesis and Immunoproteasome Formation via PRAS40 to Prevent Accumulation of Protein Stress.Hyperactivation of the Insulin Signaling Pathway Improves Intracellular Proteostasis by Coordinately Up-regulating the Proteostatic Machinery in Adipocytes.Inhibition of TORC1 signaling and increased lifespan: gained in translation?Protein Turnover in Aging and Longevity.Hsp70-Bag3 complex is a hub for proteotoxicity-induced signaling that controls protein aggregation
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Nutrient signaling in protein homeostasis: an increase in quantity at the expense of quality.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 16 April 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Nutrient signaling in protein ...... ity at the expense of quality.
@en
Nutrient signaling in protein ...... ity at the expense of quality.
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type
label
Nutrient signaling in protein ...... ity at the expense of quality.
@en
Nutrient signaling in protein ...... ity at the expense of quality.
@nl
prefLabel
Nutrient signaling in protein ...... ity at the expense of quality.
@en
Nutrient signaling in protein ...... ity at the expense of quality.
@nl
P2860
P1433
P1476
Nutrient signaling in protein ...... ity at the expense of quality.
@en
P2093
Shu-Bing Qian
P2860
P356
10.1126/SCISIGNAL.2003520
P577
2013-04-16T00:00:00Z