Mice fed rapamycin have an increase in lifespan associated with major changes in the liver transcriptome
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Finding Ponce de Leon's Pill: Challenges in Screening for Anti-Aging MoleculesThe Role of Autophagy, Mitophagy and Lysosomal Functions in Modulating Bioenergetics and Survival in the Context of Redox and Proteotoxic Damage: Implications for Neurodegenerative DiseasesInhibition of the Mechanistic Target of Rapamycin (mTOR)-Rapamycin and BeyondDeveloping criteria for evaluation of geroprotectors as a key stage toward translation to the clinicmTORC1 signaling activates NRF1 to increase cellular proteasome levelsSex- and tissue-specific changes in mTOR signaling with age in C57BL/6J miceIntermittent Administration of Rapamycin Extends the Life Span of Female C57BL/6J MiceLifespan extension and cancer prevention in HER-2/neu transgenic mice treated with low intermittent doses of rapamycinLatest progress in tyrosine kinase inhibitorsFrom rapalogs to anti-aging formula.Parallel universes of Black Six biology.Short-term rapamycin treatment in mice has few effects on the transcriptome of white adipose tissue compared to dietary restriction.Longevity, aging and rapamycin.Testing efficacy of administration of the antiaging drug rapamycin in a nonhuman primate, the common marmoset.Divergent tissue and sex effects of rapamycin on the proteasome-chaperone network of old mice.Rapamycin-induced metabolic defects are reversible in both lean and obese miceDiminished mTOR signaling: a common mode of action for endocrine longevity factors.Age-associated changes in basal NF-κB function in human CD4+ T lymphocytes via dysregulation of PI3 kinase.Gerosuppression in confluent cells.Untangling autophagy measurements: all fluxed up.Health Effects of Long-Term Rapamycin Treatment: The Impact on Mouse Health of Enteric Rapamycin Treatment from Four Months of Age throughout LifeGene expression in the liver of female, but not male mice treated with rapamycin resembles changes observed under dietary restriction.Dose-dependent effects of mTOR inhibition on weight and mitochondrial disease in miceFasting levels of hepatic p-S6 are increased in old miceComparison of rapamycin schedules in mice on high-fat diet.Koschei the immortal and anti-aging drugsMetabolic consequences of long-term rapamycin exposure on common marmoset monkeys (Callithrix jacchus)Dual mTORC1/C2 inhibitors suppress cellular geroconversion (a senescence program).The Biology of Aging: Citizen Scientists and Their Pets as a Bridge Between Research on Model Organisms and Human Subjects.Measures of Healthspan as Indices of Aging in Mice-A Recommendation.Rapamycin Increases Mortality in db/db Mice, a Mouse Model of Type 2 Diabetes.Rapamycin: An InhibiTOR of Aging Emerges From the Soil of Easter Island.Pharmaceutical inhibition of mTOR in the common marmoset: effect of rapamycin on regulators of proteostasis in a non-human primateGerosuppression by pan-mTOR inhibitors.Emerging Molecular Pathways Governing Dietary Regulation of Neural Stem Cells during Aging.Aberrant mTOR activation in senescence and aging: A mitochondrial stress response?Novel strategies for anti-aging drug discovery.Sex differences in aging: genomic instability.mTOR drives cerebral blood flow and memory deficits in LDLR(-/-) mice modeling atherosclerosis and vascular cognitive impairment.Caloric restriction: beneficial effects on brain aging and Alzheimer's disease.
P2860
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P2860
Mice fed rapamycin have an increase in lifespan associated with major changes in the liver transcriptome
description
2014 nî lūn-bûn
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2014 թուականին հրատարակուած գիտական յօդուած
@hyw
2014 թվականին հրատարակված գիտական հոդված
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2014年の論文
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2014年論文
@yue
2014年論文
@zh-hant
2014年論文
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2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Mice fed rapamycin have an inc ...... ges in the liver transcriptome
@ast
Mice fed rapamycin have an inc ...... ges in the liver transcriptome
@en
Mice fed rapamycin have an inc ...... ges in the liver transcriptome
@nl
type
label
Mice fed rapamycin have an inc ...... ges in the liver transcriptome
@ast
Mice fed rapamycin have an inc ...... ges in the liver transcriptome
@en
Mice fed rapamycin have an inc ...... ges in the liver transcriptome
@nl
prefLabel
Mice fed rapamycin have an inc ...... ges in the liver transcriptome
@ast
Mice fed rapamycin have an inc ...... ges in the liver transcriptome
@en
Mice fed rapamycin have an inc ...... ges in the liver transcriptome
@nl
P2093
P2860
P50
P3181
P1433
P1476
Mice fed rapamycin have an inc ...... ges in the liver transcriptome
@en
P2093
Arlan Richardson
Martin Javors
Vivian Diaz
Viviana I Pérez
William H Wood
Yidong Chen
Yiqiang Zhang
Yongqing Zhang
P2860
P304
P3181
P356
10.1371/JOURNAL.PONE.0083988
P407
P577
2014-01-01T00:00:00Z