Mice fed rapamycin have an increase in lifespan associated with major changes in the liver transcriptome - Wikidata - wikimedia - TriplyDB

Mice fed rapamycin have an increase in lifespan associated with major changes in the liver transcriptome

Mice fed rapamycin have an increase in lifespan associated with major changes in the liver transcriptome

http://www.wikidata.org/entity/Q28305597

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Finding Ponce de Leon's Pill: Challenges in Screening for Anti-Aging Molecules The Role of Autophagy, Mitophagy and Lysosomal Functions in Modulating Bioenergetics and Survival in the Context of Redox and Proteotoxic Damage: Implications for Neurodegenerative Diseases Inhibition of the Mechanistic Target of Rapamycin (mTOR)-Rapamycin and Beyond Developing criteria for evaluation of geroprotectors as a key stage toward translation to the clinic mTORC1 signaling activates NRF1 to increase cellular proteasome levels Sex- and tissue-specific changes in mTOR signaling with age in C57BL/6J mice Intermittent Administration of Rapamycin Extends the Life Span of Female C57BL/6J Mice Lifespan extension and cancer prevention in HER-2/neu transgenic mice treated with low intermittent doses of rapamycin Latest progress in tyrosine kinase inhibitors From rapalogs to anti-aging formula.Parallel universes of Black Six biology.Short-term rapamycin treatment in mice has few effects on the transcriptome of white adipose tissue compared to dietary restriction.Longevity, aging and rapamycin.Testing efficacy of administration of the antiaging drug rapamycin in a nonhuman primate, the common marmoset.Divergent tissue and sex effects of rapamycin on the proteasome-chaperone network of old mice.Rapamycin-induced metabolic defects are reversible in both lean and obese mice Diminished mTOR signaling: a common mode of action for endocrine longevity factors.Age-associated changes in basal NF-κB function in human CD4+ T lymphocytes via dysregulation of PI3 kinase.Gerosuppression in confluent cells.Untangling autophagy measurements: all fluxed up.Health Effects of Long-Term Rapamycin Treatment: The Impact on Mouse Health of Enteric Rapamycin Treatment from Four Months of Age throughout Life Gene expression in the liver of female, but not male mice treated with rapamycin resembles changes observed under dietary restriction.Dose-dependent effects of mTOR inhibition on weight and mitochondrial disease in mice Fasting levels of hepatic p-S6 are increased in old mice Comparison of rapamycin schedules in mice on high-fat diet.Koschei the immortal and anti-aging drugs Metabolic consequences of long-term rapamycin exposure on common marmoset monkeys (Callithrix jacchus)Dual mTORC1/C2 inhibitors suppress cellular geroconversion (a senescence program).The Biology of Aging: Citizen Scientists and Their Pets as a Bridge Between Research on Model Organisms and Human Subjects.Measures of Healthspan as Indices of Aging in Mice-A Recommendation.Rapamycin Increases Mortality in db/db Mice, a Mouse Model of Type 2 Diabetes.Rapamycin: An InhibiTOR of Aging Emerges From the Soil of Easter Island.Pharmaceutical inhibition of mTOR in the common marmoset: effect of rapamycin on regulators of proteostasis in a non-human primate Gerosuppression by pan-mTOR inhibitors.Emerging Molecular Pathways Governing Dietary Regulation of Neural Stem Cells during Aging.Aberrant mTOR activation in senescence and aging: A mitochondrial stress response?Novel strategies for anti-aging drug discovery.Sex differences in aging: genomic instability.mTOR drives cerebral blood flow and memory deficits in LDLR(-/-) mice modeling atherosclerosis and vascular cognitive impairment.Caloric restriction: beneficial effects on brain aging and Alzheimer's disease.

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P2860

Mice fed rapamycin have an increase in lifespan associated with major changes in the liver transcriptome

http://www.wikidata.org/entity/Q28305597

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2014 nî lūn-bûn

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2014 թուականին հրատարակուած գիտական յօդուած

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Yongqing Zhang

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P2860

The TOR pathway comes of age

Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice

Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity

Extending healthy life span--from yeast to humans

mTOR is a key modulator of ageing and age-related disease

mTOR signaling in growth control and disease

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

A role for autophagy in the extension of lifespan by dietary restriction in C. elegans

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

A C. elegans mutant that lives twice as long as wild type

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