Foxo1 integrates insulin signaling with mitochondrial function in the liver.
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Redox Signaling in Diabetic Nephropathy: Hypertrophy versus Death Choices in Mesangial Cells and PodocytesTranscriptional repression of mitochondrial function in aging: a novel role for the silencing mediator of retinoid and thyroid hormone receptors co-repressorForkhead box transcription factor 1: role in the pathogenesis of diabetic cardiomyopathyPrimary respiratory chain disease causes tissue-specific dysregulation of the global transcriptome and nutrient-sensing signaling networkImpaired-inactivation of FoxO1 contributes to glucose-mediated increases in serum very low-density lipoproteinTamoxifen reduces fat mass by boosting reactive oxygen speciesThe induction of microRNA targeting IRS-1 is involved in the development of insulin resistance under conditions of mitochondrial dysfunction in hepatocytes.Baicalein protects rat insulinoma INS-1 cells from palmitate-induced lipotoxicity by inducing HO-1Impact of dietary polyphenols on carbohydrate metabolism.Impact papers on aging in 2009.Insulin signaling, resistance, and the metabolic syndrome: insights from mouse models into disease mechanisms.Bile acids regulate hepatic gluconeogenic genes and farnesoid X receptor via G(alpha)i-protein-coupled receptors and the AKT pathway.Tissue-specific insulin signaling in the regulation of metabolism and aging.Myocardial loss of IRS1 and IRS2 causes heart failure and is controlled by p38α MAPK during insulin resistance.Targeting mitochondrial alterations to prevent type 2 diabetes--evidence from studies of dietary redox-active compounds.Heme oxygenase-1 drives metaflammation and insulin resistance in mouse and man.Chronic enrichment of hepatic endoplasmic reticulum-mitochondria contact leads to mitochondrial dysfunction in obesity.Targeting Forkhead box O1 from the concept to metabolic diseases: lessons from mouse models.Alteration in mitochondrial Ca(2+) uptake disrupts insulin signaling in hypertrophic cardiomyocytes.Insulin receptor substrates Irs1 and Irs2 coordinate skeletal muscle growth and metabolism via the Akt and AMPK pathways.Mitochondrial dysfunction and insulin resistance: an update.Hepatic FoxOs regulate lipid metabolism via modulation of expression of the nicotinamide phosphoribosyltransferase gene.Mitochondrial dysfunction in patients with primary congenital insulin resistance.Cobalt protoporphyrin induces HO-1 expression mediated partially by FOXO1 and reduces mitochondria-derived reactive oxygen species productionFlavin-containing monooxygenase 3 as a potential player in diabetes-associated atherosclerosis.IRS2 increases mitochondrial dysfunction and oxidative stress in a mouse model of Huntington diseaseIsotretinoin and FoxO1: A scientific hypothesis.Neuroendocrine and metabolic components of dopamine agonist amelioration of metabolic syndrome in SHR ratsDissociation of the glucose and lipid regulatory functions of FoxO1 by targeted knockin of acetylation-defective alleles in micePathophysiology and animal modeling of underactive bladder.FOXO1 increases CCL20 to promote NF-κB-dependent lymphocyte chemotaxisInsulin resistance is associated with epigenetic and genetic regulation of mitochondrial DNA in obese humans.Interferon gamma (IFN-γ) disrupts energy expenditure and metabolic homeostasis by suppressing SIRT1 transcription.Role of forkhead transcription factors in diabetes-induced oxidative stress.Control of mitochondrial activity by miRNAs.FOXO1 and GSK-3β Are Main Targets of Insulin-Mediated Myogenesis in C2C12 Muscle Cells.Elevated TCA cycle function in the pathology of diet-induced hepatic insulin resistance and fatty liver.The role of mitochondria in the pathogenesis of type 2 diabetesMitochondrial oxidative phosphorylation is impaired in patients with congenital lipodystrophyNOX4 pathway as a source of selective insulin resistance and responsiveness
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Foxo1 integrates insulin signaling with mitochondrial function in the liver.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 18 October 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Foxo1 integrates insulin signaling with mitochondrial function in the liver.
@en
Foxo1 integrates insulin signaling with mitochondrial function in the liver.
@nl
type
label
Foxo1 integrates insulin signaling with mitochondrial function in the liver.
@en
Foxo1 integrates insulin signaling with mitochondrial function in the liver.
@nl
prefLabel
Foxo1 integrates insulin signaling with mitochondrial function in the liver.
@en
Foxo1 integrates insulin signaling with mitochondrial function in the liver.
@nl
P2093
P2860
P356
P1433
P1476
Foxo1 integrates insulin signaling with mitochondrial function in the liver.
@en
P2093
Joseph T Rodgers
Kyle Copps
Pere Puigserver
Ramya Kollipara
Ronald A Depinho
Shaodong Guo
Xiaochen Dong
Zhiyong Cheng
P2860
P2888
P304
P356
10.1038/NM.2049
P407
P577
2009-10-18T00:00:00Z