Minimizing repolarization-related proarrhythmic risk in drug development and clinical practice.
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Fatalities temporally associated with the ingestion of ibogaine.The use of Xenopus oocytes in drug screening.Biomarkers and endogenous determinants of dofetilide-induced torsades de pointes in α(1) -adrenoceptor-stimulated, anaesthetized rabbits.Protein kinase A activity at the endoplasmic reticulum surface is responsible for augmentation of human ether-a-go-go-related gene product (HERG).Cardiac ventricular repolarization reserve: a principle for understanding drug-related proarrhythmic risk.Mechanisms underlying probucol-induced hERG-channel deficiency.Investigation of mechanism of drug-induced cardiac injury and torsades de pointes in cynomolgus monkeys.A novel transgenic rabbit model with reduced repolarization reserve: long QT syndrome caused by a dominant-negative mutation of the KCNE1 gene.Absolute beat-to-beat variability and instability parameters of ECG intervals: biomarkers for predicting ischaemia-induced ventricular fibrillation.QTc interval prolongation and torsade de pointes associated with second-generation antipsychotics and antidepressants: a comprehensive review.(-)-Epicatechin rescues the As2 O3 -induced HERG K(+) channel deficiency possibly through upregulating transcription factor SP1 expression.Predicting the risk of sudden cardiac death.Evidence for the hERG Liability of Antihistamines, Antipsychotics, and Anti-Infective Agents: A Systematic Literature Review From the ARITMO Project.Species-Dependent Mechanisms of Cardiac Arrhythmia: A Cellular Focus.Effects of equol on multiple K+ channels stably expressed in HEK 293 cells.In silico optimization of atrial fibrillation-selective sodium channel blocker pharmacodynamics.Up-regulation of miR-21 and miR-23a Contributes to As2 O3 -induced hERG Channel Deficiency.The rescuable function and mechanism of resveratrol on As₂O₃-induced hERG K⁺ channel deficiency.The electrophysiological effects of cardiac glycosides in human iPSC-derived cardiomyocytes and in guinea pig isolated hearts.An in silico canine cardiac midmyocardial action potential duration model as a tool for early drug safety assessment.Combined inhibition of key potassium currents has different effects on cardiac repolarization reserve and arrhythmia susceptibility in dogs and rabbits.High-throughput screening of drug-binding dynamics to HERG improves early drug safety assessment.Torsades de Pointes in the Guinea-pig heart : editorial to: "dofetilide promotes repolarization abnormalities in perfused Guinea-pig heart" by O.E. Osadchii
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Minimizing repolarization-related proarrhythmic risk in drug development and clinical practice.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on March 2010
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
@cs
name
Minimizing repolarization-rela ...... lopment and clinical practice.
@en
Minimizing repolarization-rela ...... lopment and clinical practice.
@nl
type
label
Minimizing repolarization-rela ...... lopment and clinical practice.
@en
Minimizing repolarization-rela ...... lopment and clinical practice.
@nl
prefLabel
Minimizing repolarization-rela ...... lopment and clinical practice.
@en
Minimizing repolarization-rela ...... lopment and clinical practice.
@nl
P2860
P1433
P1476
Minimizing repolarization-rela ...... elopment and clinical practice
@en
P2093
Attila S Farkas
P2860
P304
P356
10.2165/11535230-000000000-00000
P577
2010-03-01T00:00:00Z
P5875
P6179
1041978797