A highly efficient cocaine-detoxifying enzyme obtained by computational design.
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Long-acting cocaine hydrolase for addiction therapyMolecular mechanism of HIV-1 Tat interacting with human dopamine transporter.Plant expression of cocaine hydrolase-Fc fusion protein for treatment of cocaine abuse.Unexpected Reaction Pathway for butyrylcholinesterase-catalyzed inactivation of "hunger hormone" ghrelin.Long-Term Blockade of Cocaine Self-Administration and Locomotor Activation in Rats by an Adenoviral Vector-Delivered Cocaine Hydrolase.Nano-antidotes for drug overdose and poisoning.Reaction Pathway for Cocaine Hydrolase-Catalyzed Hydrolysis of (+)-Cocaine.Biologics to treat substance use disorders: Current status and new directionsFree energy profiles of cocaine esterase-cocaine binding process by molecular dynamics and potential of mean force simulations.Plant-expressed cocaine hydrolase variants of butyrylcholinesterase exhibit altered allosteric effects of cholinesterase activity and increased inhibitor sensitivityKinetic characterization of a cocaine hydrolase engineered from mouse butyrylcholinesterase.Metabolic Enzymes of Cocaine Metabolite Benzoylecgonine.Effects of a cocaine hydrolase engineered from human butyrylcholinesterase on metabolic profile of cocaine in rats.Bacterial Expression of Human Butyrylcholinesterase as a Tool for Nerve Agent Bioscavengers Development.Clinical Potential of an Enzyme-based Novel Therapy for Cocaine Overdose.Catalytic Mechanisms for Cofactor-Free Oxidase-Catalyzed Reactions: Reaction Pathways of Uricase-Catalyzed Oxidation and Hydration of Uric Acid.QM/MM Description of Newly Selected Catalytic Bioscavengers Against Organophosphorus Compounds Revealed Reactivation Stimulus Mediated by Histidine Residue in the Acyl-Binding Loop
P2860
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P2860
A highly efficient cocaine-detoxifying enzyme obtained by computational design.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 18 March 2014
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
A highly efficient cocaine-detoxifying enzyme obtained by computational design.
@en
A highly efficient cocaine-detoxifying enzyme obtained by computational design.
@nl
type
label
A highly efficient cocaine-detoxifying enzyme obtained by computational design.
@en
A highly efficient cocaine-detoxifying enzyme obtained by computational design.
@nl
prefLabel
A highly efficient cocaine-detoxifying enzyme obtained by computational design.
@en
A highly efficient cocaine-detoxifying enzyme obtained by computational design.
@nl
P2093
P2860
P356
P1476
A highly efficient cocaine-detoxifying enzyme obtained by computational design
@en
P2093
Chang-Guo Zhan
Fang Zheng
Shurong Hou
Wenchao Yang
P2860
P2888
P356
10.1038/NCOMMS4457
P407
P50
P577
2014-03-18T00:00:00Z