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Sex differences in the physiology of eatingThe pathogenesis of obesity from a genomic and systems biology perspective.Chaperoning G protein-coupled receptors: from cell biology to therapeuticsA small molecule agonist THIQ as a novel pharmacoperone for intracellularly retained melanocortin-4 receptor mutants.Defect in MAPK signaling as a cause for monogenic obesity caused by inactivating mutations in the melanocortin-4 receptor gene.Missense mutations and polymorphisms of the MC4R gene in Polish obese children and adolescents in relation to the relative body mass indexPharmacological characterization of canine melancortin-4 receptor and its natural variant V213F.Functional studies on twenty novel naturally occurring melanocortin-4 receptor mutations.Biased signaling in naturally occurring mutations in human melanocortin-3 receptor gene.The melanocortin-4 receptor: physiology, pharmacology, and pathophysiology.Functions of DPLIY motif and helix 8 of human melanocortin-3 receptor.Altered hepatic lipid metabolism in mice lacking both the melanocortin type 4 receptor and low density lipoprotein receptorThe expression of MC4Rs in D1R neurons regulates food intake and locomotor sensitization to cocaine.Brain signaling systems in the Type 2 diabetes and metabolic syndrome: promising target to treat and prevent these diseases.Hypothalamic dysfunction in obesity.Family of melanocortin receptor (MCR) genes in mammals-mutations, polymorphisms and phenotypic effects.The missense variation landscape of FTO, MC4R, and TMEM18 in obese children of African Ancestry.Biased signaling at neural melanocortin receptors in regulation of energy homeostasis.Human Protein Kinases and Obesity.Obesity Drug Update: The Lost Decade?The current state of GPCR-based drug discovery to treat metabolic disease.Pharmacoperones as Novel Therapeutics for Diverse Protein Conformational Diseases.
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 07 October 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Mutations in melanocortin-4 receptor and human obesity.
@en
Mutations in melanocortin-4 receptor and human obesity.
@nl
type
label
Mutations in melanocortin-4 receptor and human obesity.
@en
Mutations in melanocortin-4 receptor and human obesity.
@nl
prefLabel
Mutations in melanocortin-4 receptor and human obesity.
@en
Mutations in melanocortin-4 receptor and human obesity.
@nl
P1476
Mutations in melanocortin-4 receptor and human obesity
@en
P2093
Ya-Xiong Tao
P304
P356
10.1016/S1877-1173(09)88006-X
P50
P577
2009-10-07T00:00:00Z