about
Functional characterization of melanocortin-3 receptor variants identify a loss-of-function mutation involving an amino acid critical for G protein-coupled receptor activationChimeras of the rat and human FSH receptors (FSHRs) identify residues that permit or suppress transmembrane 6 mutation-induced constitutive activation of the FSHR via rearrangements of hydrophobic interactions between helices 6 and 7Brain-derived neurotrophic factor in human subjects with function-altering melanocortin-4 receptor variants.Chaperoning G protein-coupled receptors: from cell biology to therapeuticsA small molecule agonist THIQ as a novel pharmacoperone for intracellularly retained melanocortin-4 receptor mutants.Ipsen 5i is a Novel Potent Pharmacoperone for Intracellularly Retained Melanocortin-4 Receptor Mutants.Defect in MAPK signaling as a cause for monogenic obesity caused by inactivating mutations in the melanocortin-4 receptor gene.Hydrogen sulfide cytoprotective signaling is endothelial nitric oxide synthase-nitric oxide dependent.Inactivating mutations of G protein-coupled receptors and diseases: structure-function insights and therapeutic implications.Insights into food preference in hybrid F1 of Siniperca chuatsi (♀) × Siniperca scherzeri (♂) mandarin fish through transcriptome analysis.Transcriptome analysis of food habit transition from carnivory to herbivory in a typical vertebrate herbivore, grass carp Ctenopharyngodon idella.Pharmacological characterization of canine melancortin-4 receptor and its natural variant V213F.Biased signaling in naturally occurring mutations in human melanocortin-3 receptor gene.Therapeutic potential of sustained-release sodium nitrite for critical limb ischemia in the setting of metabolic syndrome.Sustained release nitrite therapy results in myocardial protection in a porcine model of metabolic syndrome with peripheral vascular disease.The melanocortin-4 receptor: physiology, pharmacology, and pathophysiology.Functions of DPLIY motif and helix 8 of human melanocortin-3 receptor.Molecular mechanisms of the neural melanocortin receptor dysfunction in severe early onset obesity.Functional characterization of nine novel naturally occurring human melanocortin-3 receptor mutations.Mutations in melanocortin-4 receptor and human obesity.Free fatty acid receptor GPR120 and pathogenesis of obesity and type 2 diabetes mellitus.G protein-coupled receptors as regulators of glucose homeostasis and therapeutic targets for diabetes mellitus.Physiology and therapeutics of the free fatty acid receptor GPR40.Targeting GPR119 for the potential treatment of type 2 diabetes mellitus.Constitutive activity in melanocortin-4 receptor: biased signaling of inverse agonists.Molecular cloning, tissue distribution, and pharmacological characterization of melanocortin-4 receptor in grass carp (Ctenopharyngodon idella).Ghrelin Receptor Mutations and Human Obesity.Pharmacological chaperones for the misfolded melanocortin-4 receptor associated with human obesity.Biased signaling at neural melanocortin receptors in regulation of energy homeostasis.Pleiotropic functions of the transmembrane domain 6 of human melanocortin-4 receptor.Functions of transmembrane domain 3 of human melanocortin-4 receptor.Expression of melanocortin receptors in human prostate cancer cell lines: MC2R activation by ACTH increases prostate cancer cell proliferation.Constitutive activity of neural melanocortin receptors.Identification and pharmacological analyses of eight naturally occurring caprine melanocortin-1 receptor mutations in three different goat breeds.Biased signaling initiated by agouti-related peptide through human melanocortin-3 and -4 receptors.Functions of acidic transmembrane residues in human melanocortin-3 receptor binding and activation.Molecular cloning and pharmacological characterization of porcine melanocortin-3 receptor.Functional characterization of novel melanocortin-3 receptor mutations identified from obese subjects.Leptin expression in mandarin fish Siniperca chuatsi (Basilewsky): Regulation by postprandial and short-term fasting treatment.Intrinsic differences in the response of the human lutropin receptor versus the human follitropin receptor to activating mutations.
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P50
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wetenschapper
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հետազոտող
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Ya-Xiong Tao
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Ya-Xiong Tao
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Ya-Xiong Tao
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Ya-Xiong Tao
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Ya-Xiong Tao
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Ya-Xiong Tao
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Ya-Xiong Tao
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Ya-Xiong Tao
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Ya-Xiong Tao
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Ya-Xiong Tao
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Ya-Xiong Tao
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Ya-Xiong Tao
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Ya-Xiong Tao
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Ya-Xiong Tao
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Ya-Xiong Tao
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P106
P1153
7402420424
P31
P496
0000-0003-4737-749X