p53-family proteins and their regulators: hubs and spokes in tumor suppression.
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Towards establishment of a rice stress response interactomeThe Modulation of Apoptotic Pathways by GammaherpesvirusesOncogenic Intra-p53 Family Member Interactions in Human CancersNovel Implications of DNA Damage Response in Drug Resistance of Malignant Cancers Obtained from the Functional Interaction between p53 Family and RUNX2Caloric restriction: is mammalian life extension linked to p53?Principles of allosteric interactions in cell signalingCell-context dependent TCF/LEF expression and function: alternative tales of repression, de-repression and activation potentialsTransactivation specificity is conserved among p53 family proteins and depends on a response element sequence codeThe rebel angel: mutant p53 as the driving oncogene in breast cancer.Interaction of p53 with the CCT complex promotes protein folding and wild-type p53 activityMolecular Mechanisms of p53 Deregulation in Cancer: An Overview in Multiple Myelomap73 as a pharmaceutical target for cancer therapyIdentification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemiaEukaryotic translation elongation factor 1-alpha 1 inhibits p53 and p73 dependent apoptosis and chemotherapy sensitivitySomatic polyploidy is associated with the upregulation of c-MYC interacting genes and EMT-like signatureInduction of p53, p21 and apoptosis by silencing the NF90/NF45 complex in human papilloma virus-transformed cervical carcinoma cells.∆N-P63α and TA-P63α exhibit intrinsic differences in transactivation specificities that depend on distinct features of DNA target sites.Mutant TP53 posttranslational modifications: challenges and opportunities.ff14IDPs force field improving the conformation sampling of intrinsically disordered proteins.Test and Evaluation of ff99IDPs Force Field for Intrinsically Disordered Proteins.The essential role of TAp73 in bortezomib-induced apoptosis in p53-deficient colorectal cancer cellsDoxorubicin and 5-fluorouracil induced accumulation and transcriptional activity of p53 are independent of the phosphorylation at serine 15 in MCF-7 breast cancer cellsTracing the protectors path from the germ line to the genome.Critical role of VCP/p97 in the pathogenesis and progression of non-small cell lung carcinoma.p53 Isoforms: An Intracellular Microprocessor?TAp63γ demethylation regulates protein stability and cellular distribution during neural stem cell differentiationTAp73 induction by nitric oxide: regulation by checkpoint kinase 1 (CHK1) and protection against apoptosis.p53 prevents neurodegeneration by regulating synaptic genes.TP53 engagement with the genome occurs in distinct local chromatin environments via pioneer factor activityIdentification of new p53 target microRNAs by bioinformatics and functional analysisIER3 is a crucial mediator of TAp73β-induced apoptosis in cervical cancer and confers etoposide sensitivity.Transgenic and knockout mice models to reveal the functions of tumor suppressor genes.Ser46 phosphorylation and prolyl-isomerase Pin1-mediated isomerization of p53 are key events in p53-dependent apoptosis induced by mutant huntingtin.TAp73 is downregulated in oocytes from women of advanced reproductive age.Targeting intrinsically disordered proteins in rational drug discovery.Regulation of p73 activity by post-translational modifications.Functional Diversification after Gene Duplication: Paralog Specific Regions of Structural Disorder and Phosphorylation in p53, p63, and p73Global tumor protein p53/p63 interactome: making a case for cisplatin chemoresistance.Ubiquitin C-terminal hydrolase l1 in tumorigenesisThe DNA binding and accumulation of p53 from breast cancer cell lines and the link with serine 15 phosphorylation
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p53-family proteins and their regulators: hubs and spokes in tumor suppression.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 09 April 2010
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
p53-family proteins and their regulators: hubs and spokes in tumor suppression.
@en
p53-family proteins and their regulators: hubs and spokes in tumor suppression.
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type
label
p53-family proteins and their regulators: hubs and spokes in tumor suppression.
@en
p53-family proteins and their regulators: hubs and spokes in tumor suppression.
@nl
prefLabel
p53-family proteins and their regulators: hubs and spokes in tumor suppression.
@en
p53-family proteins and their regulators: hubs and spokes in tumor suppression.
@nl
P2093
P2860
P356
P1476
p53-family proteins and their regulators: hubs and spokes in tumor suppression.
@en
P2093
P2860
P2888
P304
P356
10.1038/CDD.2010.35
P577
2010-04-09T00:00:00Z