Peptide nucleic acids (PNA) in chemical biology and drug discovery.
about
Nanoparticle delivery of antisense oligonucleotides and their application in the exon skipping strategy for Duchenne muscular dystrophySplicing therapy for neuromuscular diseaseDelivery of antisense peptide nucleic acids to cells by conjugation with small arginine-rich cell-penetrating peptide (R/W)9Templated synthesis of nylon nucleic acids and characterization by nuclease digestion.Phosphorylation-specific status of RNAi triggers in pharmacokinetic and biodistribution analysesSandwich assay for mixed-sequence recognition of double-stranded DNA: invader-based detection of targets specific to foodborne pathogens.Programmable multivalent display of receptor ligands using peptide nucleic acid nanoscaffolds.A biomimetic polyketide-inspired approach to small-molecule ligand discovery.Efficient preparation of internally modified single-molecule constructs using nicking enzymes.Clear-cut observation of PNA invasion using nanomechanical DNA origami devices.DNA sequencing and bar-coding using solid-state nanoporesPosition-dependent effects on stability in tricyclo-DNA modified oligonucleotide duplexesImproved synthesis strategy for peptide nucleic acids (PNA) appropriate for cell-specific fluorescence imagingPolyanionic Carboxyethyl Peptide Nucleic Acids (ce-PNAs): Synthesis and DNA BindingInvader probes: Harnessing the energy of intercalation to facilitate recognition of chromosomal DNA for diagnostic applications.Synthesis and characterization of oligodeoxyribonucleotides modified with 2'-thio-2'-deoxy-2'-S-(pyren-1-yl)methyluridineBulged Invader probes: activated duplexes for mixed-sequence dsDNA recognition with improved thermodynamic and kinetic profiles.Artificial DNA and surface plasmon resonance.Imaging mRNA Expression in Live Cells via PNA·DNA Strand Displacement-Activated ProbesPeptide conjugated phosphorodiamidate morpholino oligomers increase survival of mice challenged with Ames Bacillus anthracis.Fluorescent intercalator displacement replacement (FIDR) assay: determination of relative thermodynamic and kinetic parameters in triplex formation--a case study using triplex-forming LNAsTargeting DNA G-quadruplex structures with peptide nucleic acids.Local delivery of gene-modifying triplex-forming molecules to the epidermis.Interference of ribosomal frameshifting by antisense peptide nucleic acids suppresses SARS coronavirus replication.Electronic barcoding of a viral gene at the single-molecule levelMerging Two Strategies for Mixed-Sequence Recognition of Double-Stranded DNA: Pseudocomplementary Invader Probes.Di-heterometalation of thiol-functionalized peptide nucleic acidsCharacterization of the structural and protein recognition properties of hybrid PNA-DNA four-way junctions.Imaging mRNA expression levels in living cells with PNA·DNA binary FRET probes delivered by cationic shell-crosslinked nanoparticles.Identification and characterization of second-generation invader locked nucleic acids (LNAs) for mixed-sequence recognition of double-stranded DNA.Invaders: Recognition of Double-Stranded DNA by Using Duplexes Modified with Interstrand Zippers of 2'-O-(Pyren-1-yl)methyl-ribonucleotidesGenomic targeting of epigenetic probes using a chemically tailored Cas9 system.Effects of hypoxanthine substitution in peptide nucleic acids targeting KRAS2 oncogenic mRNA molecules: theory and experiment.Focus on PNA Flexibility and RNA Binding using Molecular Dynamics and Metadynamics.Exploring the role of chirality in nucleic acid recognition.Glycoclusters on oligonucleotide and PNA scaffolds: synthesis and applications.Towards XNA nanotechnology: new materials from synthetic genetic polymersCell penetration: scope and limitations by the application of cell-penetrating peptides.Epigenetic targets for novel therapies of lung diseases.Synthesis and properties of peptide nucleic acid labeled at the N-terminus with HiLyte Fluor 488 fluorescent dye.
P2860
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P2860
Peptide nucleic acids (PNA) in chemical biology and drug discovery.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on April 2010
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Peptide nucleic acids (PNA) in chemical biology and drug discovery.
@en
type
label
Peptide nucleic acids (PNA) in chemical biology and drug discovery.
@en
prefLabel
Peptide nucleic acids (PNA) in chemical biology and drug discovery.
@en
P356
P1476
Peptide nucleic acids (PNA) in chemical biology and drug discovery.
@en
P2093
Peter E Nielsen
P304
P356
10.1002/CBDV.201000005
P577
2010-04-01T00:00:00Z