The deubiquitinase USP28 stabilizes LSD1 and confers stem-cell-like traits to breast cancer cells
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DUBbing Cancer: Deubiquitylating Enzymes Involved in Epigenetics, DNA Damage and the Cell Cycle As Therapeutic TargetsHistone demethylase LSD1 controls the phenotypic plasticity of cancer cellsTherapeutic opportunities in Ewing sarcoma: EWS-FLI inhibition via LSD1 targetingKDM1 class flavin-dependent protein lysine demethylasesUSP28 is recruited to sites of DNA damage by the tandem BRCT domains of 53BP1 but plays a minor role in double-strand break metabolism.C/EBPα creates elite cells for iPSC reprogramming by upregulating Klf4 and increasing the levels of Lsd1 and Brd4.LSD1: biologic roles and therapeutic targeting.The progenitor state is maintained by lysine-specific demethylase 1-mediated epigenetic plasticity during Drosophila follicle cell development.Modulation of LSD1 phosphorylation by CK2/WIP1 regulates RNF168-dependent 53BP1 recruitment in response to DNA damageUbiquitin-Specific Proteases as Druggable Targets.miR-708/LSD1 axis regulates the proliferation and invasion of breast cancer cells.Epigenetic regulation of LSD1 during mammary carcinogenesis.Nuclear GSK3β promotes tumorigenesis by phosphorylating KDM1A and inducing its deubiquitylation by USP22.Regulation of XIAP Turnover Reveals a Role for USP11 in Promotion of Tumorigenesis.Functional interaction of histone deacetylase 5 (HDAC5) and lysine-specific demethylase 1 (LSD1) promotes breast cancer progression.Orthotopic non-metastatic and metastatic oral cancer mouse models.Targeting Deubiquitinating Enzymes in Glioblastoma Multiforme: Expectations and Challenges.The role of deubiquitinases in breast cancer.Phosphorylation of LSD1 at Ser112 is crucial for its function in induction of EMT and metastasis in breast cancer.Breast cancer stem cells as last soldiers eluding therapeutic burn: A hard nut to crack.Tumor suppressor SET9 guides the epigenetic plasticity of breast cancer cells and serves as an early-stage biomarker for predicting metastasis.Overexpression of ubiquitin specific proteases 44 promotes the malignancy of glioma by stabilizing tumor-promoter securin.Regulation of USP28 deubiquitinating activity by SUMO conjugationTargeting deubiquitinating enzymes in cancer stem cells.PRMT5 Is a Critical Regulator of Breast Cancer Stem Cell Function via Histone Methylation and FOXP1 Expression.Functional characterization of lysine-specific demethylase 2 (LSD2/KDM1B) in breast cancer progression.LSD1 activation promotes inducible EMT programs and modulates the tumour microenvironment in breast cancer.Inhibition of LSD1 epigenetically attenuates oral cancer growth and metastasis.Lysine-specific demethylase 1 promotes the stemness and chemoresistance of Lgr5(+) liver cancer initiating cells by suppressing negative regulators of β-catenin signaling.Targeting deubiquitinase USP28 for cancer therapy.The HNF-1β-USP28-Claspin pathway upregulates DNA damage-induced Chk1 activation in ovarian clear cell carcinoma.LSD1 mediates metabolic reprogramming by glucocorticoids during myogenic differentiation.MicroRNA-365 promotes lung carcinogenesis by downregulating the USP33/SLIT2/ROBO1 signalling pathway.KDM1A microenvironment, its oncogenic potential, and therapeutic significance.MiR-29b-1-5p is altered in BRCA1 mutant tumours and is a biomarker in basal-like breast cancerUbiquitin Regulation: The Histone Modifying Enzyme's Story
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The deubiquitinase USP28 stabilizes LSD1 and confers stem-cell-like traits to breast cancer cells
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 26 September 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
The deubiquitinase USP28 stabi ...... traits to breast cancer cells
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The deubiquitinase USP28 stabi ...... traits to breast cancer cells.
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type
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The deubiquitinase USP28 stabi ...... traits to breast cancer cells
@en
The deubiquitinase USP28 stabi ...... traits to breast cancer cells.
@nl
prefLabel
The deubiquitinase USP28 stabi ...... traits to breast cancer cells
@en
The deubiquitinase USP28 stabi ...... traits to breast cancer cells.
@nl
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P1433
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The deubiquitinase USP28 stabi ...... traits to breast cancer cells
@en
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B Mark Evers
Binhua P Zhou
Tiebang Kang
Xiuwei H Yang
Yifan Wang
Yongxiang Zhao
P2860
P304
P356
10.1016/J.CELREP.2013.08.030
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2013-09-26T00:00:00Z